Free Redacted Document - District Court of Delaware - Delaware

Case 1:04-cv-00171-GMS

Document 109-2

Filed 07/10/2006

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EXHIBIT A

Case 1:04-cv-00171-GMS

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SHEET

IN THX uiur.. S=S DISTRCT COURT

I MR. DiGIOVANNI: Your Honor, Frank DiGio\'anni

!N JJ FOR ~HE D!S'r..CT OF DElJa¡

2 from Connolly Bo\'e, local counsel for plaintiff Glii\O. Also
3 on the line is Brian Murph)' who can introduce himself.

=0 GROUP Li:=,

Plaintiff i
v.

ClVL herrON

4 MR. MUHY: Good morning, Your Honor. This is
5 Brian Murphy from Morgan Lewis & Bockius on behalf of the
6 plaintiff Glii\O. With me also is Jason Lief and Tom Puppa.

1X Pll'l!CAS US;", mc.
and ~ PHAlt~lJlCAS
INUSTRIES LI:1"..,

7 THE COURT: All right. Good morning.
NO. 04-P1 (io

Defe."lc:"lts.
10

8 For the defense?
9 MS. KELLER: Good morning, Your Honor. This is
i 0 Karen Keller from 'ioung Cona\ya)' on behalf ofTe\'a. 1 also

U
12 13
BE-FORE :

:Iu~scmy. June 30. 2005 at n: 30 a. ".
'!lZ?HOh~ co~icr

Wilington. Delaware

11 ha\'e with me on the phone Mark Schuman from Merchant & Gould

12 and John Berns is with hirn and lsabella Pols!.:y (phonetic)
HONORALE KE A. JOl11JI, U.S.D.C.J.

13 from T e\'a.

14
15

;"1?E:~~c!S :
CO~Ot.Y 30V' LODGE & mrz l r.P

14 THE COURT: All right. Good morning. 15 MR. SCHUMAN: Good morning, Your Honor.
16 THE COURT: I ha\'e the letters from counsel
17 related to the dispuie that brings us here this morning.

. 16
17

BY: E'~CIS OiGIOV'NII ESQ.

16 15 20
21
! 22

-andHORGN L.'='"S ij BCCK.-US i !.

18 Actually, it looks like broadly speaking three categories of

S~: SRI P. M"iJBY l ESQ..
J.ON LU:F j ESQ. i and

19 dispute. 20 And I'm puzzled by the first one which is a
2 i reiread of something that we did months ago. On the one

TEOH J. PO"PÌ\. ESQ.

(HQ'\ York. NeW' Yo::k)

Counsel :0: Glaxo G:oup l.i. t.ae

22 hand, I have the plaintiff saying, "hey, we had an agreement
23 and they were supposed to memorialize it" and, on rhe other

23
24

24 hand, i have the defendants saying, "we did memorialize it.

Btlan P. Gaf!iga
Official Court Repo=to.

25

25 They just don't like our answer."

4

A?r~qJl.CES (Continued):
¥O'OG CO:&~ S7A.~GAT Ii ?A-VLO?, LL B~: Kk~ E. K:UZRI ESQ.

Now, I'\'e read what you guys sent to me so I
2 don't need to you repeat what you said. But this is the

3 question i have for the plaintiffs. i went back and i

-and~'tCF.A'l & GO\1
I 6
¡ 7

4 read the trnscript again and i said, at the request of
5 Mr. J"vlurphy, "will you give something in writing which
6 memorializes the statement on the record that we're talking

E'Y: HAi: O. SCHm\., :;5Q., and
JOHN H. a£i.S, ESQ.
(P..oieapolis i Minnesot.a)

7 about here, the one matter in dispute, that is, this
8 substitution of ethanol for propylene glycol, if I'\'e got it

COll"lsel fo:: "leva Pba.ceutica.s USì, !nc. and '¡e'V"a Pha~ce.\Jticas

!ndust=ies, L1'.
- 000 -

10

9 straight?" And the response, well, the specific thing ¡vir 10 Murphy asked for, ''1i'e want that fonnalized in a stip or an
11 answer," meaning an answer referring back to contention

11 12
13

~ROCEEO!llGS
('!elephor.e conference began at 11:30 a.::.)
'tHE COU''1: Hii this is Judge Jo:;d.. 'Hho co !

12 interrogatory number six. And they said "fine." So the
13 defense says ''lye did that." So you wanted something in

. 14
15

14 \\Titing and you had agreed that contention interrogatory
15 number six being answered ought to do it.

have on the litie.?

16
17

THE :t~PHOh'" O!?~R; ! I:: so:::?
THE COUR':: I said this- is Jcdge .Jorda. Who do

16 What is your issue, Mr. Murphy? 17 MR. MURPHY: Yes, Your Honor. The issue we
18 ha\'e is simply that its not an evidentiary, its not for

1a

I have the OD the line, please?

B
20 21
Z2

'!lE lntß:PHON! O~R.'; Jui:t a ~t. 1'0
going to bring you in the con.erence.

19 evidentiary admission in order to complete the agreement,
20 which was to avoid all disco\'ery on all of

the claim

Excuse co. '!is is the operato:r. II= joining

21 elements except for the so-called ethanol limitation. And I

Judge Jo::da to the confe::ence call.
THE cOU'':; Good x:o=nng. ! need to kneW' \oho is
on the line. PloasQ identify you-:s,üt and \:ho you represent
fo:: the reco::d.

23 24
I 25

22 think tliere is an agreement in spirit. I think it's a 23 question of process.

24 THE COURT: Well, let's çut through tlie process

25 then.
United States District Cour for the District of

M001

Delaware Before the Honorable Kent A. Jorda.ri

Case 1:04-cv-00171-GMS

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SHEET 2
5

Ì'v1r. Schuman.

1 left at issue once they say we don't have anything

2 MR. SCHUMAN: Yes. 3 Trf COURT: In the lener I got from your
4 corresponding counsel, it's reiterated that you are not
5 contesting any other claim limitation in this case. Thats

2 corresponding to that. Is the way they frame that too

3 narrow? What is the issue left? MR. MURPHY: Yes, it is. It's extremely narrow 4
5 and our position has been and remains from the beginning of
6 this case that they're hiding behind an artificial

6 (he single point at issue. Have 1 misread you?

7 MR. SCHUMAN: You have not, Your Honor. And I
8 think maybe I can cut this to the chase, too. Our client is
10 stipulation I'm prepared (0 read on the recurd if

7 constrct.

8 Briefly, Your Honor, Novophan is a Canadian

9 company that started the fonnulation work for this product

this will

10 and there is only one product at issue -- not two, one

I 9 interested in doing this quickly and cheaply and I have a

II help anything. And I think it might actually do it.

Ii product, and it's alwa)'s been one product. And Novophan
12 began the formulation work many years ago in Canada when

12 THE COURT: Go ahead. 13 ìvlR. SCHUMAN: Here it is. Teva admits that the
. 14 ranitidine oral solution described in ANDA 76-937 contains 15 all the elements of Claims I through I i of U.S. Patent No.

i 3 they were not part ofTeva. Novophan first we knOll
14 fomiulated ranitidine oral solution containing ethanoL. We

i 5 also knoll that No\'ophann later formulated a series of
i 6 different solutions with different concentrations of

16 5,068,249 except the following:

17 (I), "a stabilizing effective amount of ethanol"
18 in Claims 1 through 10;

17 propylene glycol as a substtute for ethanoL. And we

18 believe, of course, thatihat \la~ in light of our patent

19 (2), "2.5 percent to i 0 percent weight/volume
20 ethanol" in claim 2;
21 (3), "7 percent

i 9 claim.
20

Novopharm fied an ANDA or Abbteviated Nell Drug

to 8 percent weight/volume

22 ethanol" in Claims 3, II and 12.

23 THE COURT: All right. Does that do it for you,
¡ 24 Mr. Murphy?

Application for the propylene glycol formulation also many 22 years ago, J think in '98 or thereabouts, and they withdrew 23 it after the Phannadyne decision by Judge Davis.
21

24

Several years later, Teva acquired the Novophann

I 25 ÌvlR. MURPHY: That's does it, Your Honor.
¡

25 company and Noyophan pur together a package of infonnation

6

THE COURT: All right.
2 (vfR. MURPHY: Thanks, lvlark.

and transfered all of the technology to their new parent

2 compan)', and Novopharm is a wholly owned subsidiary ofTeva.

3 ìvfR. SCHUMAN: You're I\elcome. i think it wasn't
4 a meeting of the minds on the language but anyway, that does

3 Teva took that final propylene glycol formulation and fied
4 a new ANDA which is the subject of

this dispute. So it's

it.

5 exactly the same fonnulation, it's one product, its always
6 been one product and all of the Novopharm documents are

6 Trf COURT: All right. Good enough. Then we're

7 done with that.
8 Lets rum to the second point which appears to

7 within the control orTeva.

8 To give )'ou an example of why I think they are
9 intentionally casting the issue very narrowly is because I

9 be in dispute which has to do with the request by Gla.\o for

10 Noyophan formulation documents. And in this instance, the
11 response that i get back from the folks at Teva is that they

10 know that they must have laboratory notebooks and
11 development reports from the original ethanol formulation

i 2 don't have any documents related to the selection of
13 propylene glycol for use in its formation.

12 and all of the different propylene glycol formulations and

i 3 we have specifically identified in the record where we have
14 been able to find reference to each of the different, each

14 MR. SCHUMAN: We have some, Your Honor.

15 Trf COURT: Maybe i misread this. I thought I
16 read on page three of

the June 29, 2005 letter, "Gla.\o

15 of the different batch numbers at least of the propylene 16 glycol fonnulation. And we have also tried to identifY
i 7 specific references 10 many notebooks wherever possible.

17 demands documents that explain Novophan's decision to
i 8 select propylene glycol for use in its formulation. Teva

18 And so, for example, the information package
i 9 that was put together is called a reformulation information

19 has found no such documents."

20 ìvfR. SCHUMAN: I'm sorry, Your Honor. The word
2 i "decision" I didn't catch when you were reading it. Thats

20 package that Novopharm wants to give to Teva don't have it.

21 We'll repeatedly ask for it. They say they can't find it.

22 the sticker there. 23 THE COURT: Okay. Well, why don't, since you
24 haven't had a chance to say anything in response to this
25 June 29th letter, Mr. Murphy, why don't you tell me what's

22 I don't believe it. We've asked for a Novopharm development
23 report on ranitidine oral solution and its propylene glycol

24 form. They say they're looking for it, can't find it. We
25 identified several places where it's referenced to different

iited States Distrct Cour for the Distrct of

M002

Delaware Before the Honorable Kent A. Jordan

Case 1:04-cv-00171-GMS

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EXHIBIT B

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Hawley's
Condensed Chemical

Dictionary
ELEVENTH EDITION
Revised by

N. Irving Sax

and
Richard J. Lewis, Sr.

ir VAN NOSTRAND REINHOLD

~ New York

Case 1:04-cv-00171-GMS

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Copyright (S 1987 by Van Nostrand Reinhold
Library of Congress Catalog Card Number 86-23333 ISBN 0-442-28097.1

All rights reserved. Cenain poriions of this work copyright (S 1930, 1920, 1919 by
The Chemical Catalog Co., Inc. and 1981, 1977, 1971, 1966, 1956. 1950 by Van Nostrand

Reinhold. No part of this work covered by the copyright hereon may be reproduced or used in any form or by any means-graphic, electronic, or mechanical. including photocopying. recording, taping, or information storage and retrieval systems-without permission of the publisher.
Printed in the United States of America
Van Nosoad Reinold

115 Firùi Avenue

New York. New York ICX3

Chapman & Hall
2-6 Boundary Row

London SEI 8HN. England
Thomas Nelson Austria 102 Dcxds Strt
South Melbourne, Victoria 3205, Austria

Nelson Caada

1120 Birhmount Road

Scarough. Ontao l\llK 5G4. Canada
15 14 13 12 11 109 8 7 6 5

Library of Congress Cataloging-in-Publication Data
Condensed chemical dictionary. Hawley's condensed chemical dictionary.

Rev. ed. of: The Condensed chemical dictionary. 10th ed./rev. by Gessner G. Hawley, 1981.
1. Chemistry-Dictionaries. i. Hawley. Gessner

Goodrich, 1905- II. Sax, N. Irving (Newton Irving)
Il. Lewis, Richard J., Sr. IV. Title.

QD5.C5 1987 540'.3'21 86-23333
ISBN 0.442-28097- 1

Case 1:04-cv-00171-GMS

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477

ETHYL ALCOHOL

in water; bp 77C; vap press 73 mm (20C); fp -83.6C; bulk density 0.8945 glml (25C); flash

Hazrd: Flammable, dangerous fire risk. Use: Specialty fuel, chemical intermediate.
ethyl-n-acetyl-u-cyanoglycine. See ethyl acetami-

!20C),
C, vap

p 24F (-4.4C); autoign temperature 800F

scosity
. Flash

(426C). Derivation: By heating acetic acid and ethyl al-

docyanoacetate.
ethyl acrylate. CAS: 140-88-5.

cohol in presence of sulfuric acid and distiling.

;ulator,

raethyl

Grade: Commercial 85-88%, 95-98%, 99%, NF (99%), FCC. Hazrd; Toxic by inhalation and skin absorption; irrtant to eyes and skin. Flammable; dangerous fire and explosion risk, flammable limits in air 2.2-9%. TLV: 40 ppm in air.
Use: General solvent in coatings and plastics, or-

CHz:CHCOOCzHs.
Properties: Colorless liquid, bp 99.4C, fp -n.oc,

d 0.9230 (20/20C), refr index 1.4037 (25e) bulk d 7.6 Ib/gal (20C), soluble in alcohol and ether, readily polymerized, flash p 60F (15.5C) (open
cup).

Derivation: (a) Ethylene cyanohydrin, ethyl alcohol, and dilute sulfuric acid; (b) Oxo Feaction

ganic synthesis, smokeless powders, pharmaceuticals, synthetic fruit essences.
; hard-

d most

ethyl acetate, anhydrous. ethyl acetate, grade

350C, 1.4980,

99%.
ethyl-o-acetate. CHsC(OCiHs)s.

of acetylene, carbon monoxide, and ethyl alcohol in the presence of nickel or cobalt catalyst. Grade: Technical (inhibited, usually with hydroquinone or its monomethyl ether), pure uninhibited.

hloride caustic
er abie-

Properties: Colorless liquid, bp 144148C, refr index 1.95 (25C), insoluble in water, soluble in
alcohol and ether, flash p 13 IF (55C). Combustible.

Hazrd: Toxic by ingestion, inhalation, skin absorption; irritant to skin and eyes. Flammable,
dangerous fire and explosion hazard. TL V: 5

ppm in air. .

imposi-

Hazrd: Moderate fire risk. Use: Intermediate.
ethyl acetic acid. See butyric acid.

Use: Monomer for acrylic resins. See also acrylate and acrylic resin.
ethyl alcohoL. (alcohol; grain alcohol; ethanol;

EtOH). CAS: 6417-5. CzHsOH.
Propertes of pure 100% absolute 'alcohol (dehydrated): Colorless, limpid, volatile liquid. Bp

~,N-di-

ethyl acetoacetate. (diacetic ester; acetoacetic

ester). CHsCOCHzCOOCzHs (keto form),
CHsC(OH):CHCOOCzHs (enol form).

78.3C, fp -117.3C, ethereal vinous odor, pungent taste. Miscible with water, methanol, ether, chloroform, and acetone. Properties: (95%) Refr index 1.651 (15C), surface tension 22.3 dynes/ cm (20C), viscosity 0.0141 poise (20C), vap press 43 mm (20C), specific heat 0.618 cal!g (23C),
flash p 55F (IDC), d 0.816 (15.56C), bp 78C, fp -114C, autoign temperature 793F (422C).

)!20C), (1 lOe)
)cyanoie).

This compound is a tautomer at room temperature consisting of about 93% keto form and 7%
enol form.
Properties: Colorless liquid, fruity odor, soluble

in water and common organic solvents, d 1.0250
(20/4C), fp (enol) -80C (keto) -39C, .bp 180-

181C, bulk d 8.5Ib/gal, vap press 0.8 mm (20C), flash p 185F (85C) (COC), coeffcient of expansion 0.00101/C. Combustible.

t! com-

Derivation: Action of metallc sodium on ethyl acetate with subsequent distilation.
Grade: Technical, 98%.

Derivation: (a) From ethylene by direct catalytic hydration or with ethyl sulfate as intermediate; (b) fermentation of biomass, especially agricul-

tural wastes; (c) enzymatic hydrolysis of cellulose
(see also cellulase).

Grade: USP (95% by volume), absolute, pure,
completely denatured, specially denatured, in-

:).

Hazard: Toxic by ingestion and inhalation; irritant
to skin and eyes.

.t odor;
e in wa~C); mp

dustrial, various proofs (one-half the proof number is the percentage of alcohol by volume).

Use: Organic synthesis, antipyrine, lacquers,
dopes, plastics, manufacture of dyes, pharmaceuticals antimalarials, vitamin B; flavoring.
ethyl acetone. See methyl propyl ketone.

Hazard: Is classified as a depressant drug. Though it is rapidly oxidized in the body and is therefore
noncumulative, ingestion of even moderate

ire risk.
lose.

amounts causes lowering of inhibitions, often

succeeded by dizziness, headache, or nausea.
ethylacetylene. (l-butyne). CAS: 107-00-6.

vinegar

CzHsC'H.
Properties: ~able as liquefied gas, bp 8.3C, d
0.669 (O/OC). fp -l30C, flash p less than 20F
(-6.6C) (TO C)

Larger intake causes loss of motor nerve control, shallow respiration, and in extreme cases unconsciousness and even death. Degree of intoxication is determined by concentration of alcohol in the

luble in soluble

, specific volume 7.2 cu/ftllb

brain. Of primary importance is the fact that
intake of even moderate amounts together with

(21.2C), insoluble in water.

Case 1:04-cv-00171-GMS

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ETHYL a-ALLYL
barbiturates or similar drugs is extremely dangerous and may even be fatal. Flammable, danger-

478

ous fire risk; flammable limits in air 3.3-19%. TLV: 1000 ppm in air.
Use: Solvent for resins, fats, fatty acids, oils, hy-

ble with water, alcohol, and ether. Derivation: From ethyl chloride and alcoholic ammonia under heat and pressure.

(OC), autoign temperature 723F (383C). Misci-

Hazrd
fire ris

drocarbons; extraction medium; manufacture of
acetaldehyde, acetic acid, ethylene, butadiene,

Grade: Technical (anhydrous and 70% aqueous
solution), pure 98.5% min.
Hazrd: Strong irritat. Flammable, dangerous

Use: Pc nyl re.
n-ethylar
C2HsÌ'

2-ethyl hexanol, dyes, pharmaceuticals, elastom-

ers, detergen ts, cleaning preparations, surface
coatings, cosmetics, explosives; antifFeeze, bever-

fire risk, flammable limits in air 3.5-14%. TL V:

io ppm in air.
Use: Dye intermediate, solvent extraction, petro-

Properti exposu
in wat

ages, antisepsis, gasohol, yeast-growth medium,
octane booster in gasoline.

leum refining, stabilzer for rubber latex, detergents, organic synthesis.
ethyl

See also alcohol, denatured; industrial alcohol, biomass.
Note: Ethanol from fermentation of biomass and

amine hydrobromide. C,HsNH,. HBr.

hydrolysis of cellulose is a significant alternate
energy source, especially as an automotive fueL.

Its use in gasoline wil continue to increase. Further information can be obtained from the National Alcohol Fuels Information Center, 1617 Cole Blvd., Golden, Colorado, 80401.
ethyl a-ally i acetoacetate. CH3COCH(CH2CH:CH2)COOC2Hs.

Properties: White, almost odorless granules; mp 158-161C; very soluble in water. Use: Intermediate (where liquid ethylamine or liquid hydrobromic acid eannot be used).

index cup). ( Derivati in pres

Hazd:

tiUatiol

absorpi
Use: Or¡

ethyl-o-aminohenzoate. See ethyl anthranilate.
ethyl-p-aminohenzoate hydrochloride. (anesthesol; benzocaine; procaine hydrochloride). CAS: 5 i -05-8. CGH.NH2C02C2Hs' HC!. Properties: White, crystallne, odorless, tasteless powder; stable in air; mp 88-92C; soluble in dilute acids; less soluble in chloroform, ether, and
alcohol; very slightly soluble in water.

o-ethylan CsH,(l' Properti,
bp 2141
in alcol

Properties: Water-white liquid, d 0.989 (20C), bulk density 8.24 Ib/gal (20C). Combustible. Use: Intermediate for pharmaceuticals, perfumes,

fungicides, insecticides, fine chemicals.

Hazrd:

bustiblc

ethyl aluminum dichloride. (EADe).
C,HsAICIi.

Derivation: Ethylation of p-nitrobenzoic acid followed by reduction.

absorpt Use: Inti pesticid
ethy J anti

Properties: Clear, yellow, pyrophoric liquid. Bp
~
~ J
;'Ö

(extrapolated) 194C, fp 32C, d 1.22, bulk d
10.28 lb/gal (2Se).

Grade: Technical, pure, NF (as benzocaine). Hazard: Toxic by ingestion. Use: Medicine (local anesthetic), suntan preparations.
ethylaminoethanol. See eth~ethanolamine.

CAS: 8

Derivation: Reaction of aluminum chloride with ethyl aluminum sesquichloride.
Hazard: Ignites on contact with air, dangerous

Propertit
refr ind propyle
Grade: 1

fire risk, reacts violently with water. Skin irrtant. Use: Catalyst for olefin polymerization, aromatic

Mixed ethylaminoethanols (sold in up to tank car
lots) may also contain diethylaminoethanol.

Use: Perl

hydrogenation; intermediate.
ethyl aluminum sesquichloride. (EASe). (C2Hs)3AbCI,.

thranila

2-ethylamino-4isopropylamino-6-methylthio-s-tri_
azine. C2HsHNC3N3(SCH3)NHCH(CH3),' Properties: White, crystalline powder; mp 84-85C;

2-ethylant Propertie
Use: Syn
"Ethyl" .A

Properties: Clear, yellow, pyrophoric liquid. Bp 204C, fp -SOC, d 1.08. Derivation: Reaction of ethyl chloride and aluminum.
Grade: CommerciaL. Hazard: Ignites on contact with air, dangerous

slightly soluble in water; soluble in organic sol.
vents.

Hazard: Toxic by ingestion.
Use: Weed-killing agent in pineapple and sugar

ries of f
ages of t
ene dicJ
All are 1
tor fuel!

cane.

fire risk, reacts violently with water. Use: Catalyst for olefin polymerization, aromatic hydrogenation; intermediate.
ethylamine. (monoethylamine; aminoethane).

ethyl-l-(p-aminophenyi)-4pheny i isonipecotate. See anileridine.
ethyl amyl ketone. (EAK; 5-methyl-3-hepta-

"Ethyl" A
line an ti

CAS: 7S-Q47. CHsCH,NH,. Properties: Colorless, volatile liquid (or gas). Am-

none). CAS: 541-85-5.

monia odor, strong alkaline reaction, bp 16.6C,
fp -81.C, d 0.689 (liquid lS/ISC), bulk d S.7

CH3CH2CO(CH,).CH3. Properties: Colorless liquid, pungent odor, insoluble in water, soluble in 4 volumes of 60% alcohol,

butyl pi
and pen

Ib/gal (20C), flash p approximately OF (-17.7C)

bp 157C, bulk d 83 lb/gal, d 0.819-0.824, refr
index 1.416, flash p 138F (5SC). Combustible.

decompi used foi
to retard
in gasoli

MOOG

~

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EXHIBIT C

1¡~

il

r~~ ii
(I I\~
i ~;

\ i~
i~
1,\1,

Case 1:04-cv-00171-GMS

\11

!J

Document 109-2

WEBSTER'S l New Collegiate s o
: a 1JØ/-~Q9
i :1

o ..

Dictionary

Filed 07/10/2006

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:¡, G. & c. MERRIAM COMPANY
;1 Springlicld, Massachusetts, U.S.A.

'--lflt~~in_

... j ,

Case 1:04-cv-00171-GMS

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Copyright (£1973 by G. & C. Merriam Co.

Philppines Copynght 1973 by G. & C. Merriam Co.

Library of Congress Cataloging in Publication Data

Main entr under title: .
Webster's new collegiate dictionar.

"Based on Webster's third new international

dictionar."
"A Merram-Webster."

Edtions for 1898-1948 have title: Webstèr's collegiate

dictiona; 1949-1 and 1973 edtions have title:
Webster's new collegiate dictionar: 1963-72 editions

have title: Webster's seventh new collegiate dictionaiy.
1. Englh language-Dictionaries.

PE1628,W4M4 1973 423 72-10966
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0-87779-309-3 (indexed) 0-87779-310-7 (Buks)'n)

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Made in the United States of America

o
Mooa

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21
perception or imminent danger 4: a warning notice syn se FEAR
2alarri also alarum yl ,: to give warning to: put on the alert 2: to strike with rear: TERRtFY 3: DISTURB. EXCtTE - alarm.

alarm. ale
el.cai,de or al.cay.de \al-'kid-ë\ n (Sp aleaide, rr..Ar al-qö'id the

ant assurance, composure

captain): a commander or a catle or fortress (as among Spaniards,
Portugues, or Moors)

al.cal.de \al-'kii-dë\ n ISp. rr. Ar ai.qadi the judge) : the chier
administrative and judicial offcer of a Spanish town al.oe.zar \al-kíl-or, -'kaz- \ n (Sp aleázar. rr. Ar al-qosr the castieJ
AI.ces.tls \al-'sc.tas\ n (L, fro Gk Alkeslls): the wife or Admelus

ing.iy \-Iär.mi"irlë\ ady
desired time

alarm clock n : a clock that ca be set to sound an alarm at a
alarm.ism \:i'Iär..iz.~m\ n : the orten unwarrented exciting or reas or warning or danger - alarm.ist \.m;it\ n or adj alarm reaction n : the complex or reactions or an organism to

: a Spanish fortres or palace .
adj

who dies for her husband and is restored to him by Hercules

stress (6S by increa hormonal activity)
disordered activity

al.che.mist \'al-k:im"st\ n: one who studies or practice alchemy _ al.che.mis.tlc \.l-k:i'mis.tik\ ar al.che.mI8,tl.cal \-ti-k~l\

'~'"

alarums and excursions n pI i.: martial sounds and the

movem'ent or soldiers across the stage - used as a stage direction
in Elizbethan draa 2: clamor, excitement, and feverish or

al.che.mize \'al.k;¡iz\ Vi -mized: .miz.ing : to change by

alchemy: TRANSMUTE
al.che.my \'aI-k:imë\ n rME alkamle, alquemie. fro MF or ML:

¡~" ..:..:'....

alas \:i'Ias\ interj (ME. fr. OF, rr. a ah + las weary, rr. L ,= or concern
_ more at lET)- used to express unhappiness. pity,

MF a/(luemie. rr. ML arehymia. fro At al.kimiyà~ fro 01 the +

krmiyã alchemy. fro LGk eMmeia) i: a medieval chemcal

Alas.kan malamute \:iJas.k.m¡\ n : any of a bree of powerful heavr.-cated deep-hested dogs of Alaskan origin with erect ears.
heavtly cushioned reet, and plumy tail ~ :
Alas.ka time \".'Ias.k:i\ n: the time or the 10th time ZOne west of Greenwich that includes cetral Alska

scence and speulative philosophy aiming to achieve the transmutation of the bas metals into gold. the discovery of a univers cure ror disee, and the discovery of a means of indefinitely prolongig
life 2: a power or proce of transforming someihin¡¡ common
into sc:mething precious - a.l.chem.ic. \al-'k,:m.ik\ oral.cham.l. cal'\.i-k"l\ ad; - al.chem.i.cal.ly \-i-k(:i)Ie\ adv

alata \'a.Jät\ also alat.ad \-Jãt-~d\ adj (L alarus, rr. ala): having
wings or a winglike part - ala.tion \ã-'Iã-sh"n\ n alb \'àlb\ n (ME albe. fr. OE, fro ML alba fr. LA fem. or albus
white): a rull.length white linen vestment with long sleeves that

Alc.mo.ne \alk-'më-né\ n (Gk Alkmenéj: the mother or Hercules
by Zeus In the form or her husband Amphitryon
al.co.hol \.al.k..höl\ n (NL, fro ML, powdered antimony, rr. OSp.

is gathered at the waist with a cincture and worn by a priest at Mass

fro At al-kuhulthe powdered antimony) i: a colorles volatile
flammable ¡¡quid C~H.O .that is the into~icating agent in fermented

- see VESMENT illustrtion . .
Alb abbr Albania; Albanian

and distiled liquors and is used also as a solvent -called also eihyl

al.ba.core \'al-bNõ(,,)r. ..kò(;i)r\ n. pi -core or -cores (Pg
: any of several caragid fishes

alcohol 2: any or various compounds that are analogous to ethyl

caned tuna; brodly : any of varous tunas (as a bonito) 2

olbacor. fro Ar al-bakùrah the albacore) i: a large pelagic tuna (Thunnus alalunga) with long petoral fins that is a source or

alcohol in constitution and that are hydroxyl derivatives or

hydrocrbons 3: liquor (as ber, wine, or whiskey) containing
alcohol

1al.co.hol.ìe \.l-k:i'hòl-ik, -'hii. \ adj' t a : or, relating to, or

AI.ba.nian \al.'bã-në-~D. -ny"n also öl-\ n i: a native or inhabitat of Albania 2: the Indo-Europen languge or the

Albanian peple - se tNOQWROPEAN lANGUAGES table - AI.

al.ba.tross \.al.b..tròs. ..trä\ r'"

banian adj .' .
Pg or Sp aleatrt peica): any

2alcoholic n : one afected with alcoholism

caused by alcohol b: containing alcohol 2: affected with alcoholism - al.co.hoi.j.al.ly \-¡-k(;¡)lë\ ady
compulsive use or alcoholic drinks 2: poisoning by alcohol; esp

al:co.hol.ism \'al.k:iõ-iz-~m\ n i: continucó excesive or

n, pi .tross or -tross.as (prob. . alter. or alcatras (water bird), fro
or variouS large web-footed seinclude the largest' seabirds

al.eo.hol.ize \..iz\ VI -izad: -iz.ing ~ to treat or saturate with

birds (ramily Diomedeidae) that

al.co.hol.om.e.tor \,-k:iå-'Iäm-"t-"r\ n (F alcolamètre, fr.
aleoal alcohol + -0 + -mètre -meter): a device for determining the alcoholic strength of liquids - al.co.hol.om.e.try \-'1am-dtrë\ n

alcohol .,
sociated with exceive and usu. compulsive drinking
al-aur'ön. lit.. the reading) archaic: KORAN

: a complex chronic psychologica and nutritional disorder as-

are related to the petrels and

al.be.do \al-bëd-(,)õ\ n. pl-dos (LL. . whitenes, fro L olbus)

AI.co.ran \,-k:i'ra\ n (ME, fro MF or ML; MF & ML fro Ar
al.cóvo \'a..õv\ n (F aleôve, fro Sp alcabo fro At al-lubbeh the

:renective power specif: the fraction of incident light or electromagnetic radiation that is refected by Ìl surface or body albatros." (as the meen or a cloud) . al.be-.it \öl-'b"t, al- \ conj (ME, lit., all though it be): conceng the ract that: even though $yn
Al.bl.gen:ses \,-b~'jen..sez\ n pi rML, pi. or Albigensis lit.,
.Catharistic sect of southern Frace betwee tbe i lth and 13th
AI.bi.gan.sian.ism \..ìz-~m\ n

arch). 1 a : a small rec setion of a room : NOOK. b : an arched opeing. (as in a wall) : NtCHE 2: SUMMERHOUSE - al.

covad \.:õvd\ adj,

see THOUGH

aId aMr alderan

AI.ey.o.ne \al-'si..(Jnë\ n (L fro Gk Alkyone): the brightest star in the Pleiades
AI.deb.a.ran \al-'deb.:ir:n\ n rAr al-dabarãn,

lit., the follower)

inhabitat of Albi, fro Albiga (Albj), Fracel : members. or a.
centuries - AI.bl.gen.sian \-'jen-ch"n. -'jen(i).¡;"n \ adj or n -

and is ihe brightest star in tht Hyades .
die \,.d:i'hid-ik\ adj

:. a red sta of the first magnil\Jde .that is se in the eye or Taurus
alcohol dehvdrogenaium deydrogenated alcohol) : ACETALDE.
HYDE: brodly: any.of varous highiy reactive compounds typified

al,de.hyde \'al-diiid\ n (G aldehyd. fro NL aL dehyd.: abbr. or

al.bi.nism \ 'a'b:iìz-~m, al-'bl- \ n : the condition of an albino al.bi.no \al.'bi-(,)nõ\ n, pI-nos often arrrib (Pg. fro Sp, fro albe white, rr. L albus): an organism eiibiting defcient pigmentation;

by acetadehyde and charcterzed by the group CHO - al.de.hy.

in pigment and usu. has a milky or trashicet skin, white or
colorles hair, and eyes with pink or blue iris and deep-red pupil -

es¡r: a human beng or lower animal that is congenitaly deficient

al.der \'öl-d"r\ n (ME, fro OE alor. akin to OHG elira alder. L
alnus): any Of a genus (Alnus) or toothed-leaved tree or shrubs

al.bi.not.ic \,.b¡'nät-ik\ adj (albino + -iie (as in melanaiie)) i : of. relating to. or afected with albinism 2: tending toward AI.bi.on \'al-be-"n\ n (L)1 : Great Britan 2: England

al.bin.ic \-bin-ik\ adj . .

of the birch family growing in moist ground and having woo used

albinism ..' .

al.der.man \'òl.d~r-m~n\ n (ME. fro OE ealdorman. fro ealdor
govering a kingdom, district. or shire as viceroy". for an AngloSaon king 2: a magistrate ranking ne~t beow the mayor in an

by turer and bark use ,in dyeing and taning .

parent (fr. eald old) + man - more at .olD) i: a person

al.bite \'al..bit\ n (Sw albit, fro L albus) : a triclinic usu. white

English or Irish city or borough 3:. a member of a city legislative
body - al.der.man.ic \iöl-d~r-'man-ik\ adj .

feldspar consisting of a sodium aluminum silicate NaAISip, - al. bit.ic \al.'bit-ik \ adj al.bum \'al-b~m\ n (L, a white tablet. fro neut. of albus) i a
: a book with blank pages ror autographs. staps, or photographs

al.dol \'al..òJ, ..õl\ n (lSV aldehyde + -of) : a colorles

beta-hydroxy aldehyde C.H,Oi us esp. in orgaic synthesis; brodl, : any or various similar aldehydes - al.dol.iza.tion

b: a papeboard container ror a phonogrph reord: JACKET c
: one or more lon¡¡-playing phonograph reords or tape recrdin~s
: ANTOLOGY,
al.bu.men \al-'byü-man\ n (L, fro albus) 1: the white.

\,..o-l;¡'z-sh~n, ..õ-\ n. .

al.dol.ase \'al-d:iãs. ..ãz\ n (aldol + -ae): a crystalline enzyme

produce as a single unit 0(£1 2-recrd -;: 2: a collection usu. io

book form of literary selections, musica compositions. or.pictues

or an egg

al.dose \'al..õs, ..õz\ n (lSV aldehyde + -ae) : a sugar
or the boy

that ocurs widely in living systems and catayz reversibly the cleavage of a fructose ester into trose sugars

- see EGG ilustration 2: ALBUMIN al.bu.min \al.'byü-m~n\ n (ISV albumen + -in): any or numerous simple heat-coaguable water-soluble proteins that ocur in

al.do.ste.rone \aI-.dös-t..rõn. .a-dõ-st:i'rõn\ n (aldehyde + -0

containing one aldehyde group per molecule .
+ sterol + -one): a steroid hormone CIJH'óNiO of the adrenal

cortex that functions in the reguation or the sat and water balance
al.do.ste.ron.ism \-.ö.iz.~m, -'rõ- \ n : a condition that is
chacterze by excesive.production and excretion or

blood plasma or seru, muscle. the wbites of eggs, milk. and other

lal.bu.min.oid .\-m:iöid\ adj: resembling albumin: PROTElN

animal substance and in many plant tissues and nuids
having the properties of albumen 'or albumin

2albuminoid n i: PROTEIN 2: SCLEROPROTEIN

aldosterone and typicaly by loss or body potasium. musular weaess, and

al.bu.min.ous \al-'byü-m..n;is\ adj : relating to. containing, or
al.bu.min.uria \(,)al..byU-m;¡'nCy)ur-c"\ n (NL): the presnce of in the urine often symptomatic or kidney diseae - al.bu. albumin. min.uric \-nCy)u(~)r-ik\ adj
al.bu.mose \'al-byd-õs, -.mõz\ n (F. fro albumine albumen +
-ose): any of varous products of enzymatic protein hydrolysis al.bur.num \al-'b"r-n"m\ n (L, fro albus white): SAPwrv",

al.drin \'öl-dr.m. 'ai-\ n (Kurt Alder tl958 G chemist + E -in)
: an exceingly poisonous cyclodiene inseticide C,~Hóci.

elevated blood presure ....

ale \'ä(,,)l\ n (ME. rr. OE ealu; akin ioON ol ale; L alumen alum)
i: a fermented liquor brewed esp. by rapid feimentation from an

a Ie abbr alcohol

al.ca.ic \al-'kã-ik\ adj, often cae (LL Alcoieu or A MOO 9
Alkaikos fr. Alkaios Aleseus, jl ab 60 B.C. Gk pot or written in a verse or strophe marked by complic
or ~ nominant iambic aaHern - alcaie n

i ch
iin
Ü loot
ii root

kitten

ar rurher a back ã bae ä cot, ca

e les e eay g giri trip i lie

Õ flow ó flaw òi coin th th t. ths

y ye' yÜ rew yu furous ib vion

Case 1:04-cv-00171-GMS

Document 109-2

Filed 07/10/2006

Page 13 of 31

REDACTED VERSION ­ PUBLICLY FILED
estradiol. Ethiopic
. ,.

392
a: having infinite duration: EVERI'ASllNG b: of or relating to eternity c: characterize by abiding fellowship with God -(ood

ea.tra.di.ol \..tr".'dl..ol, .:l\ n (lSV esrai (fr. esrrin) + di. +
ea.tral \'es.tr.l\ adj: CSROUS

C,iH"O, \!u. made syntheticaly and that is often used combined as an ester' esp. in treating menopausa symptoms

-on : an estrogenic hormone'that is a phenolic steroid alcohol

estral cycle n : CSROUS CYCLE .
. es:trange \is-'trãnj\ VI es.tranged; ,ea.trang.lng (MF eslranger.

endles 3 archaic : INFERNAL. 4: valid or existing et all times
Zeternal n i cap: GOD I - used with rhe 2: sometling eteral

teacher. what must I do to inherii ~ life? -MI 10:17 (RSY)). 2 a : continued without intermission: PERPETAL b: seingly
: TtMEI.ES 0(- verities). - etar.nal.ize \-'l-.\ vI - eter.nal.ly

fro ML exlraneare fro L exrrteus strange' - more at STANGE)'
i : to remove from customary environment or assoctions 2

\.'l.ë\ adv - etar.nal.ness n

: to arous esp.'mutua enmity or indifference in wher there had
.'11

eterne \i.'t;)rn\ adj (ME, f1. MF. fro L aeremus) archaic: lIERNAI.

formerly be love, affection, or friendlines:. ALIENATE - estrange.ment \.'trãnj.m;)nt\ n - es.trang.er n

ater.nj.ty \i-'t;)r-n;)t.c\ n, pi .ties (ME elemile. fro MF eremiié. fr. L aeremÌlar-. aeiemiias fr. aeiemus) 1: the quaity or .state of

beng eternal 2: infinite time 3 pt : AGES 4: the state after
death: IMMORTALITY 5: e seinglr endles or immeaurable
time .(e pose motionles for a seening - as the crowd roared with laughter and encouragement -J. W. Cross). .

: to cause one to brea a bond of afection or loyalty 8nt recncile
Ill'
..!

syn ESRANGE. ALIENATE. DtSAFFCT. WEAN shared meaning elemeni

'es.tray \is.'trä\ vi (MF esiraier) archaic: STRAY

etar.niza \i.'t;)r-.ïz\ vI .nlzed; .niz.lng i ll: to make eternal b

2estray n : STRAY I es.trin \'es.tn:m\ n (NL esrru) : an estrogenic hormone; esp

,"

es.tri-ol \'es..trj-.l, e-'stñ., ..l\ n (estrin + rri. + -01) : a
crystalline estrogenic hormone that is a glycol C,aH"O¡ usU.
obtaned from the urie of .pi:egnant women

: ESRONE

ete,slan \i.'tc.zhan \ adj, often cap (L erosiu$, fr. Gk eresios fro eros

ii

ea.tro.gen \'es-tn:j;)n\ n LN!: esirus + iSY -0 + -gen) : a

substace (as a. se hormone) tendig to promote estru and
stimulate the development of secnda se: charteristics in the

eth \'eth \ var of EDH eth. or etho- comb form (lSV): ethyl o(erhaldehYde). o(eihochlo-

es.tro.gen.je \.tn:'jen-ik\ adj i: promoting estrus 2: of,

female .

relting, to, or caus by an estrogen - es.tro.gen.i.cal.ly
females, and is use,(similarly to estrdiol

'-ath \;)th, ith\ ar .th \th\ vb suffix (ME, fro OE -eih, -ath. .ih; akin to OHG .ii, ..~ -er, 3d sing. ending. L .1. .ii) - use to fonn the archac third person singuar presnt of verbs o(goeih). o(doih).
/ eth.a.cryn.jè acid \.th.:rn-ik-\ 11 fperh. fro erh- + acetic +

ride). .
\-,t;)r-n:r'z-sh;)n \ n

: to prolong indefinitely 2: IMMORTALIzE - eter.ni.za.tion

year - more at WETER): recurrng annualy - us of summer winds tbat blow over the Medterea ~ etesian n, often cap

2.th - se .TH

\.i.k(".)Ië\ adv es.trone \'estrõn\ n i:SV, fr. esirin): an estrogenic hormone that
r ~:

is a ketone C,IH"O, is usu. obtained from the urie of pregnant

es.trous \'estr.s\ adj 1: of, relating to. or charactersiic of

estru 2: beng. in heat . .
cycte.

treatment of edema eth.am.bu.tol \eth.'am.byú-,tol, ..tõl\ n (erhylene: + omine + butaol): a compound CIoHi.N,O¡ used esp. in the treatment of
eth,ane \'eth-.\ n (ISV, fro eihyl): a colorless odorles gaeous

butyryl + phenol) : a diuretic Cllfl"Cl,O, 'use esp. in the

estrous cycle n : the correlated phenomena of the endocrine and

tubercuosis .. .
gas

generative systems of a female mammal from the beginning of one
"

peod of estr to the beginning of the ne:t - caled also esrral
es.tru.al \'es.trw;)l\ adj: CSROUS
¡,

hydrocrbon C,H. found in natura ga and us esp. as a fuel eth.a.nol.amine \.th-".'näJ-;;fu, .'nõl- \ n : a colorles liquid
eth.a.nol \'eth-;ròl, ..nõl\ n : AI.COHOI. I .
amino alcohol C¡HiNO use esp. as a solvent

es.trus \'es-im\ or es.trum \.tmm\ n (NL, fro L oelru gadfly,
,e'

and in scrubbiIlg

frenzy, fr. Gk oisiro - more at IRE) 1 a: a regularly recurrent

eth.ene \'eth-.\ n : ETHYLENE
ether \'e.th;)r\ n (ME. fro L aeiher, fro Gk aiihér, fro aiihein to ignite. blaz) 1 a: the raefied element formerly beieved to fill

state of seua excitabilty durn¡s which the female of most

mamrns will a=pt the male and is capable of conceving: HEAT
b: a single ocurence of this state 2: CSROUS CYCLE

es.tu.ar.j.al \.(h).:i'wer.e-;)I\ adj: ESAR1NE
(iì

the upper regions of space b: the uppe regions of space

es.tu.a.rine \'es(h).h".w:in, -.fu\ adJ : of, relaiing to, or
formed in an estuary 0(- currents). 0(- animals). o(~ environ-

: HEAVENS 2 a: a medium that in the undulatory theory of light

peeates all space and trasmits trasverse waves. b : the
medium that trasmits radio waves 3 a: a light volatile flammable liquid C.HIOO use chiefly as a solvent and anesthetic b : any of various organic compounds charcterize by an oxygen
atom attached to two carbon atoms - ether.ish \-th".rish\ adj-

menD

es.tu.ary \'es(h).h:rwer-e\ n. pi -ar.jes (L aosruarium. fro aesrus

boiling, tide: akin to L aesias summer - more at AESVAL) : a water passage where the iide meets a river current: osp: an arm of
I

.

'~l'

asu.ri.ence \i-'súr-e-;)n(i)s, -'zr- \ n : the quality or state of beng esunent
esu.rj.an.cy \-;)n-se\ n : ESURIENCE eau.ri.ent \.;)nt\ adj (L esn'ent-. esun'en", prp. of esun're to be

ESU abbr electrostatic unit

the se at the lower end of a river .

ather.like \.th;)r-Jik\ ad) .

ethe.re.al \i.'thir-e;)l\ adj i a : of or relating to the regions

beyond the eath b: CELESAL HEAVENLY c: UNWORI.I.Y.
SPIRITAL. 2 a: lacking material substace: IMMATERIAL INTAN.

OIBI.E b: marked by unusua delicacy and refinement o(this

.~

ESV abòr eah satellite vehicle
at Vet\ diat par of EAT

hungryl: HUNGRY. GREEDY - esu.ri.ent.ly adv

smallest. most -, and dantiest of birds -William Bebe 3 : relatig to. contaning, or resbling a.chemca ether - ethere.al.i.ty \..thir..'al.;)t-e\ n - ethe.ra.al.iza.tion \.C.:iI".'Z. sh;)n\ n - ethe.re.al.lze \.'thir-e-:lïz\ vI - etha.ra.al.ly
soluble in ether and consists chie1y of fats and fatty acids ethe.rie \i.'ther.ik, .'thir- \ adj: ETEREAL

I.
i,.'

Et symbol ethyl ET abbr eatern time -at \'et, .et, ;)t, it\ n suffix fME, fro OF -er, mas.. &: -ere. fern., fro

\-ë-:rlë\ adv - ethe.re.al.ness n ethar extract n : the part of a comple: organic material that is

eta \'ãt.;), 'ët-;)\ n (LL, fro Gk éia, of $e origin: akin to Heb liéih

o(octer).

LL .irus &: .¡¡a) i: smalf one o(baronei). o(cellarel). 2: group

ether.iza \'c.th..ñz\ vI .ized; .iz.ing i: to treat or anesthetize

with ether 2 : to make numb as if by anesthetizing - ather.
jza.tlon \,-th:rr:'z-sh;)n\ n - ether.lz.er n eth.le \'eth.ik\ n (ME eihik. fr. MF eihique. fro L erhice. fro Gk éihike fro ethiko) i pi bur sing or pi in conslr : the discpline

ETA abbr estimated time of arrval éta.gère ar eta.siere \.ä..ta-'ze(;))r, ,ãt;,\ n (F étagèrej : an elaborate whatnot

heth): the 7th letter of the Gree alphabet - see ALPHABET table

dealing with what is goo and bad and with moral duty and
individual or a group o(professional - s).

often with a large mirror at the back and sometimes with an enclosed cabinet as a
base

obligation 2 a: a set of moral principles or values b: a theory or system of moral values o(the present-day materialistic..). cpt

bili sing or pt in canSlr: the principles of conduct. governing an

et al \et-'al, -'01\ abbr (L el alii (mas.), er aliae (fem.), or et alia (neut.)) and others
eta.mlne \'ät-:ro!en\ n (F eramine) : a

'eth.i.cal \'eth.i-k;)l\ alSo eth.ic \.ik\ adj (ME eiik. fro L eihicus fr. Gk eihikc", fro eihos charcterJ i: of or relating to ethics 2

light cotton or worsted fabric with an open
mesh
etat.ism \ä.'täi-iz.;)m\ n (F étarisme. fro érar state, fr. OF esral): STATE SOCALISM - etat.lst \-'tät-;)st\ adj

: conforming to accpted profesional standards of conduct 3 of
a drug: restricted to sae only on a doctor's presriptiotf syn see
MORAL 8nt unethica - eth.¡.cel.i.ty \.th.".'kal.;)t-ë\ n - eth

2ethical n : an ethical drug

i.ca¡'y \'eth.i.k(:r)lë\ adv - eth.l.cal.ness \-k;)l-n~s\ n

etc \an.'sõ-fõrth, -'corth: et.'set-:ir:, .'se. 'h
et.cet.era n 1: a number of unspeì!ed
additional persons or things 2 pi : un.

tr. \ abbr et cetera ll

l~
ctngcre

¡

lli,

ethi.eian \e-'thilh.an\ n : EticiST ath.i.clst \'eth-:is;)st\ n : a speialist in ethics eth.l.on \'eth.ë-,än \ n (blend of eth. and ihion.): an organophosphate C,HiiO.P,S, used as a peticide

specified additional items : ODDS AND
ENDS

eth.i.on.amida \.eth-e."án-:ro!id\ n (eth. + rhion- + amide)
ethi.o.nlne \e.'thi-:rnën\ n ¡eth- + ihion- + -inel: an amino
: a compound C1HION¡S used against mycobacteria (as in tuber. culosis and leprosy)

at eet.era \et.'set-:rr;). .'se.tm\ (L): and others esp. of the same kind: and so forth 'etch \'ech\ vb (D eIen, f1. G äizen. lit., to feed, fr. OHG =en; akin to OHG ezn to eat - more at EAT) vI i ll: to produce esp.
on metal or glass by the corrosive action of an acid b: to subject

acid C.H I¡NO,S thei is the ethyl homologue of methionine and is

Ethl.op \'ë-thë.,äp\ or Ethl.ope \.,p\ n (ME Eihiope. f1.L
'Ethl.o.pl.an \.e.thë-'õ-pe-;)n\ n i: a member of any of the mythical or actual ~oples usu. described by the ancient Grees as
dark-skinned and Iiving far to the south 2: NEGRO 3: a native
Aethiop", fro Gk Aithiops) archaic: ETIOPIAN

biologically antagonistic to methionine .

to such etching 2: to delineate or impress clearly -:cees that are
I i ¡ i

i
"

indelibly -ed in our minds). - vi: to practice etching - etcher n 2eteh n i: the action or effect of an etching acid on a surface 2 : e chemical agent used in etching

etch.jnG n 1 a : the act or procs of etching b: the art of
producing pictures or desi¡:ns by printing from an etched metal
plate 2 a : an etched desgn b: an impression from an etched

2Ethloplan adj' 1 : of, relatin$ to, or characteristic of the inhabi. tants or the country of Ethiopia 2: of. relaiing to, or beng the

or inhabitant of Ethiopia

r
í ,

ie:Clnrl~ ~ate ETD abbr estimeted time of departure 'eter.nal \i-'t;)rn.'I\ adj (ME. fr. MF, fr. LL aele M 0 1 0

southern Arabia, and sometimes Madagascr and the adjacent
',p-ik. .'õ-pik\ ad) 1: ETHIOPIAN 2 a: of, relating ,ting Ethiopic b: of. relatin¡¡ (0, or constituting a .
ed Seitic languages spoken In Ethiopia

biogeographic region that includes Africe south of the Sahara,

aelemus eternal; akin to L aevum age, eternity - mo

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CRC Handbook
OF

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Chemistry and Physics
A Ready-Reference Book of Chemica and Physical Data

I

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EDITOR

ROBERT C. WEAST, Ph.D.
Vice President. Research. Consolidaled Natural Gas Service Company, Inc.

Fonnerly Professor o/Chemistr at Case Inso'iuie of Technology

ASSOCIATE EDITOR
I

.MELVIN J. ASTLE, Ph.D.
Formerly Professor of Organic Chemistr al Case Institute of Technology

, . ..' ~nd..... '. . .
" :~

In cOllab.'oiatlon' will a iÚg~ iÌumber of professional chemists and physi~ists

.' '-, .'. . ,., ". " , .,.. .
?: .:'i ""
; ',;J':;

.MafU¥! pf Research al GI~dden.Diirkee Division of SCl Corporation

whose assistance .is acknowledged in the list of general collaboratoFS and in .' "'connection with the particular tab:les or sections involve~.

~ .'

. eRe PRESS, me.
Boca Raton, FJorldä'3343

0'

M012
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~ 1974, 1975, 1976, 1977, 1978 by CRC Press, Inc. e 1964, 1965,1966,1967, 1968, 1969, 1970, 1971, 1972, 1973 by THE CHEMICAL RUB-

BER CO. .
I

Copyright 1918, 1920 by The Chemic Rubber Company (Copyrigt renewed 1946, 1948 by Oiemica Rubber PublLg Company)

CopYrit 1922 (CoPYrit renewed 1950), 1925 (CopYrit renewe.d 1953), 1926 (Copyright

l

renewed 1954), 1927 (Copyrit renewed 1955), 1929 (CopYrit renewed Ì957), 1936, 1937

(Copyrit renewed 1965 by The Oiemic Rubber Co,), 1939,1940 (CoPyrit renewed 1968 by The Ch'emic Rubber Co.), 1941 (Copyrit renewed 1969. by The Chemica Rubber Co.), 1942 (Copyrit renewed 1970 by The Chemica Rubber Cò.); 1943 (èoPYrit renewed 1971 by The Chemica Rubber Co.), 1944 (Copyrit renèwed 1972 by The Chemica Rubber Co.),
1945'(Copyrit renewed 1973 by The Che¡nica Rubber CO.),1947,1949,1950,

1951, 1952.

1953, 1954, 1955, 1956 by Chemica Rubber Publishin Company
~ 1957,1958,1959,1960,1961,1962 by Chemical Rubber Publishing Company

Second Prtig, 1979

All Rights Resered
Libra of Congres Cad No.1 3-1056

PRINTED IN U.S.A.
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PHYSICAL CONSI ANT OF ORGANIC COMPOUNDS (Contiued)
Color.
No.

Name

Synonym and Fonmila

Mol.
wr.

crYStalline

Solubili,
m,p. 'C

rorm.

b.p.

speific rotation and i_. (log 'i
77

'C

Density

".
w

Ref.

.1

eth aee b,

other
s.lvc:nts

1,1 ,2,i-Ethatetrc.xylic acid
n el26 -,ietraethyl

e321
n e328

_.ttlnimçthyl . .. .

318.33 teU" pr (i..peth) ~icr... E.thyl diinalonaie. (C,H,O,C),CHCH(CO ,C,H,), cr (eth. d. bi)

305d

1.0(,u;

1.4lOS'c

, ... ... ...
"
h h

....... ..
Hgi

a2'.699
B2', 699 ai', 341

Methyldlm.lonate. j262.ii
meui. Etyl thio.lrohol.C,H,SH
C,H,SNa

138

...".- ... ..... .......
)~"C
O.839Hii

...

"

i;hiol' ....

c.tu-

.. Ethyl hydronido. Ethyl

(CH,O,C),CHCH(CO,Ol,), 62.13 i"195(3.15),
ll5.h (2.2)

_144.4
d

~,4)105)0

, , ,

,

, ... dilalks
I

c329 -.sodium $al!. . . . . Sodium thoeyl3,te.
n e330 _.i....aÜno....

84.li \,,'bai.;
195 (L.IS). US th (2.2)

... ..
'"

........ ....... , ........ ........ ,
1.4929H
1.5593~(¡

...

.......

BI,341

....

CY$taiie.
H,NOl,CH,SH

7715 cr (,ub)
96.58

99100

eJ31
n e332

. ~.i..lol".... .., OOl,CH,SH........... .. Ol,CHIC,H,)SH .. .....

-,I-pl-/)' ..

elll
ellS

c3l4 1.1 ,i.Et

1.1,1.Et ca:c o.'
caxyl o.'

CH,qCO,Hh.. ....... ...
Carboxysu. Acid. HO,CCH,Ol(CO,H),

138.i. (lIlbo -89 1.1,e~6)
16i.iO pi 16i.10 pr(w)

......... .... .....,.. ..... ..
159d

sub (vac 1.1826:0 113uØ 19~iOO I.On¡Ø !)IQ

... ,

... ... .., dilliO, , , , ... ... diox" ...... ...
s

S...\431
BI'.1381 IW.445
iu112.026

178d

-.I,i-4ydrxy.. . DesU!k;i.d.

194.10 hyg (+ Iw)

.5d
_117.3

n 0336 EIl .. .. . .. ..

add _ Et acid.. . . . . ue AceEthylalalboi. AIhoL
Melbyl carlol.

HO,CCOH)COH(CO,Hh
46.07 i'- 181 (2.51) 47.08
102.13

........ ..... .. ,.,... , . , ........ ..... .. .. ... .. v , , v ...... ........ ...... .. d ... C ... ... ..... ....
78.5

... , ... ... .. ..... .. h' .. ...' ..

Bi',6S1

5l,S86
Bti.1213

Q,789Ho

1.361 iio

'" '"
'"

'"
'"

'" '"

'"
'"

, ,
,

di1.

(-112.3 4"

"'''

e337

-'0-)... .......

C,H,OH o-Di;iuoe3.Do1. Deutcr.. .
oxye1e. C,H,OD

n e338 _,i.aUyloxyr . . . . . Alyl ~oSQlve. GlYa)lmonoaUyl ether.

,............ ....... .......... ... .......
97

78.8ii~

a.solP
O.9SW!G

i.3610~.

aa '"

159'"

1.435Su

,
'"

.. . .. .
h

64"

Ca., MeOH. Ca.,

BI'.I2S7
BI,468
CSl.

I I
I
I
. ..; ¡ ;:1

n 0339

n e340 -.i..ai.......

-.i.......... Aceu.debyde-amtorùa, CH,Ol(OH)NH,
dlJ1xY'

CH,:OlOl,OCH,CH,OH

61.09 m (eth.al) 61.09

110 hd

...,.... .""
1.01801°

.. , ..,
'"

.. . .. .
h

........

Coloe.l!lbanlarooe.
H,NOl,CH,OH

.......... ."

10.3

¡70"o 58'

1.454)10

c

1008. gly""",1 a: B4",717

chlsHß~

_ _.i~ailD_i(3,4: :::1

m Non (/)
56-7 (40) i60" H,NCH,CH(OH)C;H, . . . . 137.18 nd. (a.I.-h-peth) LOO 72-4 .64.42 nd(.i)

;.. .

o el41

'f ;
. ~i:1

pby!r (I) -.i_.i. pbyl.. _,I.ami,i. ttidn c33 -.m-i
e342

Oiloril-unoní..

O,CCH(OH)NH,
104.15

dhyt.)..

H,NCH,CH,NHCli,Ol,OH

hygliq

........ ........
108

238-

........ ........ , , ... .. ...... ........ h , Y h 0.9556;' 1.4860l0 , ,

.. .

... ... ....

a13'.361
B111651

, .........
.. .

... ......... ll,i86

40":
(alr)

'. ,...¡

r f'
;;ï

~q
~ c' :.

e34
e34S

. .. ~
~.. . ....;1

-.i(oCopbyl)' e3.6 -.i-iloxy. ..,
drroYl)"

-.iii-i pleiyl).'

......................... ............,............
GlyGol monobcn-ryl ether.

137.18 yein air

15i-l

In.18 nd(.i)
152.iO

...".,., ....
24O(l.8).
32 (4.i).

e: -75
69-70

C,H,CH,OCH,CH,OH
4.'" -Oichloro-a.methyl.

:,!,;;

e34' _,I,I.bIs(4-

267.16 çr (al-w) i"'lI
370,h (3.51.

........ 1.S849lY , ... ... ... .., ......... B13=t)62 ........ ........ ........ ." "6 ... ... .. ....... al3'.36i ~'.41l 1.Ct~0 J.5233H , , . ... ... ...,..... 156'lO 1381) , ... , ......... Am 13. I ......., ........ ....,... ì 1856

9\.'

beniydrolOimite.

i
I
I

I Ji
¡'i

'I

4Sl(4.9),

j' ' l.' .

n eJ7
n 0348
n 0349

_.l..f".......
-.z.""",xy.. . . . . .

EthylC'e bromobydrin.

124.97

........... ........
......... .... ........ ............. ........

500,h(l.01)

1495OHO

i.Î6i91~
O.901S¡O

1,49iS1l

'"
'"

'"
'"

'" '"

." ...
..,
..'

00$'
Ug.

al',137

arCH,Ol,OH
Glycol monobutyl ethei.
118.18 117.19

51'

17iUl
50'

1.4198"
1.+43710

... ." ....... .. al'.519

r

: 'j
r1j

_,2-btyWfIn.'.

C.H;NHCH,Ol,OH..... .
OCH,CH,OH Siyrenedilorohydri.

C,H;OOl,CH,OH

19~
Zoo'ue 91_211

O.890n°

, , ,
'"
h

,........

fl,i83
ILL '.lll

n

03 SO

_.i-dorr. . . . . . . Ethyltediloroh)'drin.

80.52
156.61

el51
n e352

_.i-àorI.
e-xy). .

r :11
I

.i :j ;j

pb.. _.iil-àro_,l..c:XY)". "

C,li,Cl(OHlCH,O

¡;loroethyl ""Unsolve.

1i4.57

n

O3SL

M othylC)elohexylcabinoL.1i8.ll

C10l,CH,OC,CH,Oli

1 n elS4

r

-.i.qdOXYI" . . .... ....... .-...

.......

128.ll
114.19 114.96

............. _67.5 12S,n 1.200i1¡~ 01" ............. .... ..,. 128ii L.19l6¡C 91.51" .......... ... ........ 18tH5 ........ 91_2u .9l5;e ,....... 189 1"255 (3.8) ~n_iii .,......... .. ........ 201-9'$1 ~.9ii91Q
..... ... .. .. ..... ... .... ..... .. ........
91_91) 183-4OQ P,9180;: 96-1)4 1.40l) 146w;

1.44189" '"

.. 0' '"

1.55i3" .. .
1.450SI.
1.4677'0
1,4641 HI

n el5S -.2.qeJoperyl.' n e356 -2,i-didloro.'

...

,....................

1.4S77l~

, .., ... ......... B6'. 44 , '" '" ." ... ......... B11.519 .., ,...... B6i, 21 ... , , , , ... . ....... B6',i7 .. . ~'.25 .. , ." ... .... i
,
h

. . . O,CHCH,OH.......... .
Se Aecldyde, i.bydrxY'.

1.4626')

.

,

... ..,

... m,ii8

37-8'

- -.i.i-dxy.' . .

:1 j

diethyla=l

For exlanations. $)mbob and abbrcvi.Lions s. beginning or table. For ~\ructUfli formull se Q)d or table.

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PHYSICAL CONSTANT OF ORGANIC COMPOUNDS (Continued)
I
No. Name

Synon)'rn and Formula

MoL. form. wi. specific rotiilion

Color. crystallint-

m,p. 'C

b.p.
'C

Solubility
Dcnsii)"

"0
w

Ref
al

and .1.... tIoe 'i

eih ace bi

other
:iol..ents

I

i -Propanearsnic acid
n pJ2j¡ 1.Prop;ine:rsnic addp1212 i .Propa.eboronic:

CHiCH,CHlAsO,HJ
n-Propylboric acid.

-.,.

168.03 nd (a.!), pl(w)
81.9~ wh nd

))'.65.2
101

..
d

...... ....

.. . ..

....

v v J

v

i

....,
...
.. .

11-,997
84J,I023
84',1965

.. ....

....,
.. ..

,

,

...
..

I

add-

CH,CH,CH,ß(OHli
bobuiylboric ;:c;íd.
101.9'

pl2lJ -.2--ethyl.. , . ,

-

n p12J4 1.1-Prpi;nC'ioJ. .. Propylene styeot. CH,CH(OH)CH,OH

Proprioic ici-

(CH,L,CliCH,ßCOH),
uc l'blotiadd 16.C I

I i2 lopllw).", (CICH,CH:Q)

..

,.... ........
J.036J~Cl

,
'"

,

......

...

......,.

189

96-ii
ilOIC

1.4324'0

'"

, ... ,
v
\'

.........
..... .... ...... ...
AcOEi v

BI',2H2

n pl235 -,carbonate.
pl2J6 -,diaCGlate. .

..... .....

4- Meih~+ J .3.oio:tolan- 2.

102.09

one. CH,CO ,CH(CH,)CH ,O,CCH,

........... .. -48.8 .......... ." ........
~ -W

2.0

L204J;°
I.OS9lo

1.4189:'

v \'

v

.

C49.
12303

J9o-i'u
115

i.4173il
1.43701Ø

,
V

, .. . . ..
V \' \'

B2',312

l
I

pl243 -.sulfte . . . . . . . ..

.................... ..... 122.14...., ...... ..
TrimethyJc:c glycol.

1.2960;~

n p1244

1,..Prpiiiol

7~1I

....

'"

p12.5 -.di;,ceiatc.

.....

HOCH,CH,CH,OH.

CH.1CO:CH:CH :CH;iO :CCH,

Ilw.17

... "..... ...
ndorß
(M,OHI

........ ......,.
3 7.-1L

8Su 21J.5ho i .0597~o 1.4398" 1IOu 1.4192 209-10'~ 1.0101.
84.StO

d
'"
\'

V

v

esi,
1036

'"

s

......... " ... '" ... ...,.,..
...
J

BI',540
B2',IS6
C34,

n pl2l0
n pJ2ll

-.i.aa:o2--yl.-,2..min
-,i.amin
-.2-biyl.
2(hydxy. aielyl).-

CH,CH,ClCfl,OH),NH, . .

160.17 119.11 y'

14J_SIØ

J.099;0

1.490:0

00 \'

H,NctCH,OH),..... . ...
CH,ctCH,OH),NH, .

121.H

110.i-J.
109-11

219-2011

n

p12S:i

n pl2lJ

2-myl.-

10l.I'
wh

.........

4U)

mO-

........ ....,
O.929~g

..

... ... ... .. .. ... ... ... ... M,OHs'
, .. .

1l0l
C49.
LlS?

ISt.2ll
262
12)1$'

....... ...."..
IA581"
1.4809:~

\'

...
..
'"

.......
...
..

C34.

n

p12S4

i,2-Prp*n-iol,

2..1.-

CH,(CH,),C(C,H,1 (CH:OH),
Q:.cniorohydrin.

43.8

J

, .. ,
v

1l0l
Am 10, 3121

pl255

-.-.diò\i:ate. . . . OCH,C!(O,CCH,)CH,O,CCH,
flOCli,CHQCH:OH .....

3-loro-

110.54 yesh liq

.. .

'..-

213d

l.n6:~
1.1991"

,

,

..... ....

BI'.21l0

QCH,CH(OH)CH,OH

IIW.26
194.62

pl2l6 1.3.Prcptnedìol. Z--loro-.
pl2S1

110.5'

I.Z.Pr~ioL
3-corOo

QCH,ctOHICCH,)CH,OH 124.1

..,.......... ... ..... ... ........ .. ...... .. ........... ... .....
wh

i16H
24S 1161:

1.447:Ø
1.4S:Ua.

... ,
v

, .. ... ... .. .... B2',31l
..
'"
v ... ... .... ... ... .........

J46"
114-1" 80'"

1.J119¡~

BI'.l42
BI',2188

1.2362.'

1.4'48;~

'"

'"

l
I

n pl2l8
p1259

2~etyl.. -.3,Jieoxy.' . . su GI,yi;ebyde,

1,..Pr~ol.
I,Z.Pr~oL
3(dietyl.

diethyl açet~l

2,2-delyl.-

HOCH,ctC,H,),CH,OH ..

132.21

61.-.6

2'0-1
1311,)

1.052~~

(C,H,),NCH,CH(OHiCH,OH

,yr

... .....
130

l33-5
2061"1

..... ........ ....

\'

v

V

, , ,
"

,
v

, ...
v

... 0," liSi ... dll,

Am 10. 946

8-. JO~

n p1260 1,3.Prpaneiol.
pl261 1,Z.Prl"edioC,

aminr-

2,-deiyl.3(dúiyJ. smi)..-

HOCH,C(CH,L,CH,O~ '" 100.ll nd(bz)

11m2
(CH ,L,NCH,CH(OH)CH,OH
119.17

.............

... .....
J42
58

120-30' 2201...

........ .... ".. ."..... ... .....
........ ........ ........ .."...

,
" 00 V

,

... ,. ........ ... ." dlJs ...
" i

Bt,),2199

84.302
C45,

I

pl262

1,..Prpsedol,

n pl263 -.2-e)1.Z. bydroxyed)'l-' n p1264 -,Z-ey¡'Z.

l,..intr..-

HOCH,C(NO:hCH,oH " .
TMP. Trimethylolprop;ant.

166.09 wh pi (b2)

..

.... .. ........ .. ....

diox.,

13'.18 wh pWQrpl

160'

'"
\'

...
\'

.. .

ca.;

PliNO;$~

C5

9413

-

1,2.Pr~iol.
Z(hydnxy.

i:lrr"

CH,CH,C(O,)(CH,OH),. 149.ll
su GlyceL. l-hexdecJ ether
Pc:ntagtycerol. TrimcthyloJ.

CH,CH,ctCH,OHL,

nd(w) ,t.'

l1-l

d

... ...

2111

BI.483

280,h(l.61)
204

n pii65
n pl266
p1261

3-deloxy.I,.Prpaol,
meùl).Z.
metb)'i-"

IZO.15 wh pwornd

J3S_7u

........ ........
........
1.2455"
i.OO24¡~

00

'"

i

...

i

aavl

Bi,)i2J.8

ethane. CH,C(CH,OHh.
O,NctCH,OHL, . .
I..ThioglyccroL

(al)
151.12

I

-.l(dn'''.

I

HSCH,CH(OHlCH,OH. 90.12 pl268 -.Z-meth)1-' .. . . , lsoburyl",. gJ,ccl. (CH,l,C(OHlCH:OH pl269 1.3..Propa.iol, 1l.12 mel CH,ctNO,j(CH,OHL,. ....
~HDctbyJ.i..

1.i-Prpllol,
J-erc:pto."

aietrlH.lltr. .

...

ndorpr

16l(144) d

.. ,.....
l.l268"
1,43S0io

v

v

,
J
v

.. . .. .
v
¡

108.1 vi",

........ ...........' ..-.....
149-50

1001'
1ì6'lC 19-801 i d

J

'"

,..' .... .. ... "..

51).596
BP 1 iJ39

,
\'

,
\'

........ ........
... ...

... ..... ... ... ... ... ... ..,
hxsl.

BI'.2181

a1\219O
Ain72,
3116

iiitro.'
p1210 -.2.metbyl.Z.

2,2.bis(hydroxymOihyll-

IJ2.21 or (iu)

62-3

23'

........

, ... ... ... . .. 0,"

I

-

propy.'

1,2.Prp.nolol,

pl271 1,3.PTopiiedlone.

J-decloxy..' 2,-dlbr""I,3. di¡i,I.-

suGly~i.I.oC\.dcci
ether

(HOCH,i,QCH,)(CH:hCH,
382.06 pr(eih)
95

petae.

c.H,COCBr,COC,H,.... .

........
........1........

...

J

s'

... ...

0' J

87,772

For CJp!.naiions. symbols and abbreviations see bçginning orlable. For 5u'UCtural rormulas se end or table_

I

C.4S0

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EXHIBIT E

Case 1:04-cv-00171-GMS

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Filed 07/10/2006

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CONTAINS CONFIDENTIAL INFORMATION UNDER PROTECTIVE ORDER
IN THE UNITED STATES DISTRICT COURT DISTRICT OF DELAWARE
GLAXO GROUP LIMITED,
Plaintiff,
v.

Civil Action No. 04-171-KAJ

TEV A PHARMACEUTICALS USA, me. AND TEV A PHARt1ACEUTICAL INDUSTRlES LIMITED,
Defendants.

BRADLEY D. ANDERSON, Ph.D. FED. R. CIV. P. 26(a)(2) EXPERT WITNESS REPORT CONCERNING THE ISSUE OF INFRINGEMENT OF GLAXO'S '249 PATENT

M016

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Ò

~ev

Å'lv\.0

I J

M017

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~eÒ

~0Ò1JV

12

M018

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03/16/20as
16:56
UK ASTECC 257-2489 7 91212J096001P4511758~

NO. 498 Q002

101. I may supp lemcnt or amt:nd my opin ions expressed in th is Expert Witness Report
ifnew or additional information is provided 10 me or becomes available trom

Teva or Teva's expert witnesses. ¡ understand that expert report may be
provided by Teva. I reserve the right to respond 10 all matters raised by Tcva and
to testimony and opinions offered by Teva's witnesses.

Date: March l= 2006

Bradley D. An erson, Ph.D.

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EXHIBIT F

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CONTAINS CONFIDENTIAL INFORMATION

UNER PROTECTIVE ORDER
IN THE UNITED STATES DISTRICT COURT DISTRICT OF DELAWARE
GLAXO GROUP LIMITED,
Plaintiff,
v.

Civil Action No. 04-171- KAJ

TEV A PHAACEUTICALS
USA, INC. AND TEVA PHARMACEUTICAL INDUSTRIES LIMITED,

Defendants.

BRADLEY D. io\..DERSON, Ph.D. FED. R. CIV. P. 26(a)(2) REBUTTAL EXPERT WITNESS REPORT

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75. I may supplement or amend my opinions expressed in !hs Expert Witne~s

Report if new or additional inormaton is provided to me or bemes
available from Teva or Teva's expert witnesses, 1 rerve the right to

repond to all matters rased by Teva and to !tmony an opinions
offered by Teva's witness.

Date: April 2:-M006

Bradley D. Andern, Ph.D.

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