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? Case 1 :04-cv-00174-JJF Document 102-2 Filed 03/17/2005 Page 1 of 2
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l. A synthetic gene which is capable of modifying target gene expression in a cell, tissue ;v_
o organ of a prokaryotic or eukaryotic organism which is transfected or transformed
/ 5 ther ith, wherein said synthetic gene at least comprises a structural gene sequence .\ `_
cornpris g a nucleotide sequence which is substantially identical to the nucleotide ° Yi
y sequence o said target gene or a derivative thereof or a complementary sequence Q
J \ thereto place perably under the control of a promoter sequence which is operable
Qi in Said ¤¤ll» tim M ¤ts¤¤-
2. A synthetic gene which `s capable of modifying the expression ofa target gene in a ·
cell, tissue or organ of a p kaiyotic or eukaryotic organism which is ¤’9u1SY€€¥€d OY
T transformed therewith, whe in said synthetic gene at least comprises ,multiple · T ..
structural gene sequences, where each of said structural gene sequences comprises 1 I
li *1 ¤¤¤l¤¤ud¢ sequence which is subs tially identical to the nucleotide sequence of ° ;
said target gene or a derivative thereo or a complementary sequence thereto and `
wherein said multiple structural gene seque s are placed operably under the control il
lii l of a single promoter sequence which is operab in said cell, tissue or organ.
_ 20 3. A synthetic gene which is capable of modifying the ex rcssion of a target gene in a P
cell, tissue or organ of a prokaryote or eukaryote which is ansfected or transformed
· therewith wherein said synthetic gene at least comprises rn ltiple structural gene
V ,g sequences wherein each of said structural gene sequences is place operably under the fl
control of a promoter sequence which is operable in said cell, tiss e or organ and
»> 25 wherein €¤<>h of said structural gene sequences comprises a nucleotide se uenee which
Q .· is substantially identical to the nucleotide sequence of said target gene or a crivative
V vi- thereof OY a COmPl€m€DUil`y S€Q\l€iiLc [hereto,
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{ Case 1 :04-cv-00174-JJF Document 102-2 Filed 03/17/2005 Page 2 of 2
‘ EE-AL NUMBER FILING DATE CLASS GROUP ART UNIT ATTORNEY DOCKET NO.
I 09/100,812 06/19/98 $20 1646 11626
· MICHAEL WAYNE GRAHAM, ST. LUCIA, AUSTRALIA.
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**CONTINUING DOMESTIC DATA******************1*** A/Iv-;
e VERIFIED
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A A **371 DATA******k*·kk*t***i<*·k*·k$k IW
VERIFIED A
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·; **FOREIGN APPLICATIONS************ Z
VERIFIED AUSTRALIA PP2292 03/20/98
A F ' P' ‘t I ` d YI lj STATE OR SHEETS TOTAL N
3%r?IgAC IAIOEAIZ-grgngditicns met xg; [jg; [III/Ist ¤ftcrAIIOwance COUNTRY DRAWING CLAIMS IQIBSKAESNDENT
_ Verified and Ackriowaaagers ’ AUX 28 3 3 33
stcmimitlimim ITIHEI
A SCULLY SCOTT MURPHY & PRESSER
°’ § 400 GARDEN CITY PLAZA
H 5 GARDEN CITY NY 11530
, 2
SYNTHETIC GENES AND GENETIC CONSTRUCTS COMPRISING SAME I
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? A FILING FEE A
, necaivsn _ . . . III AII FGGS
j FEES. Authority has been given in Paper E] 1 16 Fees (Fume)
N0. to charge/credit DEPOSIT ACCOUNT L17 Fees (Preeeeeine Ext ef tim
$3,666 NO. for the following: E 1_18Feee(|eeue)
’ ’ I;] Other ____
I] Credit
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Case 1:04-cv-00174-JJF

Document 102-2

Filed 03/17/2005

Page 1 of 2

Case 1:04-cv-00174-JJF

Document 102-2

Filed 03/17/2005

Page 2 of 2