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CURRICULUM VITAE ROBIN A. FELDER, Ph.D.
ADDRESS: University of Virginia Health Sciences Center Post Office Box 800403 Charlottesville, Virginia 22908 April 25, 1954 Ft. Monmouth, New Jersey Georgetown University Biochemistry, 1978-1983 Ph.D. - Biochemistry, February 1983 The College of William and Mary, 1973-1977 B.S. - Chemistry, May 1977 CURRENT POSITIONS: 2002 ­ present January 2000 -present Chairman of the Board, Global Cell Solutions, Charlottesville, VA Director, Medical Automation Research Center, University of Virginia, Charlottesville, VA Visiting Professor of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD CEO ­ MedicalAutomation.org (non-profit educational organization), Charlottesville, VA CEO ­ Medical Robotics LLC, Charlottesville, VA CEO ­ Hypogen Inc., Charlottesville, VA Professor of Pathology, Associate Director of Clinical Chemistry and Toxicology, University of Virginia, Charlottesville, VA Associate Director of Clinical Chemistry and Toxicology, University of Virginia Health Sciences Center, Charlottesville, VA Editor, Journal of the Association for Laboratory Automation President, Association for Laboratory Automation Founder and CEO, Association for Laboratory Automation Co-founder, Medical Automation Systems, Inc. Associate Professor of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA Assistant Professor of Pathology, University of Virginia Health Sciences Center, Charlottesville, VA Post-doctoral fellow under John Kebabian, National Institutes of Neurological and Communicative Disorders and Stroke, Experimental Therapeutics Branch, National Institutes of Health, Bethesda, MD

BIRTH DATE: BIRTHPLACE: EDUCATION:

March 2002 - present July 1996 - present July 1984 ­ present

EXPERIENCE: July 1996 ­ Feb 2003 July 1996 ­ Dec 2002 July 1995 - Dec 2000 March 1995 ­ March 1997 July 1990 - June 1996 July 1984 - June 1990 April 1983 - May 1984

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April 1982 - June 1984 July 1981 - March 1982 July 1980 ­ July 1982 June 1977 ­ July 1984

Instructor, Department of Pediatrics, Georgetown University Hospital, Washington, D.C. Research Associate, Department of Pediatrics, Georgetown University Hospital, Washington, D.C. Director, Neonatal Intensive Care Laboratory, Georgetown University Hospital, Washington, D.C. Assistant Supervisor - Neonatology Laboratory, Georgetown University Hospital, Washington, D.C. Instructor of Chemistry, Mount Vernon College, Washington, D.C. and House Resident - Counselor for undergraduate females 09.13.05 12.09.03 09.24.03 05.05.03 04.08.03 10.22.02 02.20.01 04.25.99 05.20.97 11.22.94

PATENTS: Automated Storage and Retrieval Apparatus for Freezers #6,941,762 G Protein-Related Kinase #6,660,474 Automated Storage/Retrieval Apparatus for Freezers #6,581,395 Automated Storage/Retrieval Apparatus for Freezers #6,688,123 Automated Robotic Pickup and Delivery System #6,543,983 Automated Storage/Retrieval Apparatus for Freezers #6,467,285 Interactive Remote Sample Analysis System #6192320 Interactive Remote Sample Analysis System #6055487 Interactive Remote Sample Analysis System #5631844 Robotically Operated Laboratory System #5366896 PATENTS PENDING: Biosensor for Analyzing Tear Chemistry, #60/652,641 NAPS, Non-Invasive Analysis of Physiologic Signals 60/514,677 Automated Cell Culture System and Process 60/488,068 Automated Storage and Retrieval Apparatus for Freezers 10/429,490 Axial Extraction of DNA Point of Care Information Technology (POCT) Activities for Daily Living 60/380,347 Blood pressure scale 60/369,181 Gait Monitoring 60/369,182 ElderCare walker 60/360,077 Aptobot 60/351,956 SmartHouse 60/323,165 Genes for Human Hypertension PCT/US99/00663 Pick and Place 09/501,863 AWARDS: 2004 2004 2003

Provisional 02.14.05 Provisional 10.27.03 Provisional 07.17.03 Provisional Provisional Provisional 06.21.02 Provisional 05.14.02 Provisional 04.01.02 Provisional 04.01.02 Provisional 02.26.02 Provisional 01.25.02 Provisional 09.18.01 Provisional 01.00.98 Provisional 07.07.98

Outstanding Speaker Award 2004, AACC (American Association for Clinical Chemistry) 2nd Place, Darden-UVA Business Plan Competition, Spring 2004, Gupta U, Felder RA AACC Outstanding Speaker Award

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2003 2003 2003 2003 2002 2002 2002 1998 1996 1991 1989 1983 1981

Best Business Plan, Charlottesville Venture Group (CVG), Spring 2003 Business Spotlight (selected top business plan and presentation out of 11 entries for quarterly business plan review), Hullman A, Jose P, Felder R 4th Place, First Annual Purdue National Life Sciences Business Plan Competition, sponsored by Hoffman-LaRoche and Roche Diagnostics, April 2003 (4th place out of 46 entries from around the US), Hullman A, Jose P, Felder R Finalist, Century Club of George Mason University, Spring 2003 Grubstake Breakfast (quarterly business plan review and presentation), Hullman A, Jose P, Felder R Darden Business School Annual Business Concept Competition (1st place), Noninvasive Analysis of Physiologic Signals (NAPS), Mack D, Stefan V, Kell S, Alwan M, Felder RA 1st Place, Darden-UVA Business Plan Competition, Spring 2002, Hullman A, Jose P, Felder R Point-of-Care Connectivity Award ­ The Connectivity Consortium, hosted by Enterprise Analysis Corporation, Stamford, CT Rocket Award, presented to BioPhile Inc, a technology-based company co-founded by Dr. Felder, and based on his patented technology, presented by the Virginia Piedmont Technology Council Tech Awards) VHS Group Annual "Mover and Shaker Award" for laboratory automation Manitoba Society for Clinical Chemistry Annual Award, Manitoba, Canada Fogarty International Fellowship Young Clinical Investigator Award, Association for Clinical Scientists Young Investigator Award, American Federation for Clinical Research Young Investigator Award, American Physiological Society

PROFESSIONAL ORGANIZATIONS: American Heart Association American Federation for Clinical Research American Association for Clinical Chemistry Association for Clinical Scientists Association for Laboratory Automation American Society of Hypertension Association for Pathology Informatics International Society for Biological and Environmental Repositories Society for Biomolecular Screening Virginia Biotechnology Association Virginia Society of Pathologists CURRENT COMMITTEES AND OTHER POSITIONS: Co-Chair, Medical Automation.org, Helsinki, Finland Chair, Awards Committee, TETHICS Judge for ComputerWorld Honors Program Scientific Planning Committee, AACC Annual Laboratory Automation Conference Scientific Planning Committee, AACC European Laboratory Automation Conference 2005 - present 2004 - 2005 2003 - 2005 2004 - present 2004 - present

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Board Directors of Targeson LLC Chair, AACC Laboratory Automation Conference 2007 Chair, Board of Directors, Global Cell Solutions Chair, Medical Automation Conference, Helsinki, Finland 2007 Scientific Advisory Board, Cell Mechanics Speaker Series Advisory Board, Darden Business School, Batten Institute, University of Virginia Advisory Board, Healthcare Unbound Conference Health Data Scientific Awards Committee Advisory Board for Intelliject (Darden Business/Incubator) Cell Mechanics, Scientific Advisory Board Loudoun County Science and Technology Cabinet Fellow of the National Academy of Clinical Biochemistry Fellow of the Council for High Blood Pressure Research Member, Scientific Advisory Board: Guidance Technologies Inc. Genetic Diagnostics Inc. Integritech Inc. Counselor, Japanese Cherry Blossom Symposium Governing Council Chairman, MARC workshops (two held annually at UVA) Member Editorial Board: Advance News Magazine Chair of Scientific Advisory Board, BioPhile Inc. Member, UVA Strategic Planning National/International Strategy Workgroup Member, Scientific Advisory Board: Genesis Therapeutics, Inc. Carilion Biomedical Institute Labotix Inc. Chairman, EuroLabAutomation Conference CEO, Association for Laboratory Automation Founder, Association for Laboratory Automation Editor, Journal of the Association for Laboratory Automation Chairman, LabAutomation conference High Throughput Screening, 31st Annual American Chemical Society Western Regional Meeting, San Diego, CA Member Editorial Board: Clin Chem Acta Advance News Magazine Clinical and Experimental Hypertension Laboratory Information Management Laboratory Robotics and Automation Chairman of the International Symposium on Automation Robotics and Artificial Intelligence Applied to Analytical Chemistry and Laboratory Medicine Chairman, The Oak Ridge Conference Member of the Scientific and Organizational Board of the Second

2004 - present 2004 - present 2003 - present 2003 - present 2003 - present 2003 - present 2003 - present 2003 - present 2003 - present 2002 - present 2002 - present 2000 - present 2000 - present 2001 - present 2000 - present 1998 - present 1998 - present 1995 - present 1995 - present 2001 - 2003 2000 2001 - 2002 1999 - 2002 1998 - 1999 1998 - 2002 1995 - 2000 1995 1995 - 2003 1995 - 2002 1995 1999 - 2004 1995 - 2003 1993 - 1999 1992 - 1999 1992 - 1998 1993 - 1995 1992 - 1994

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International Symposium on Automation, Robotics, and Artificial Intelligence Applied to Analytical Chemistry and Laboratory Medicine Chairman, International Conference on Robotics in Laboratory Medicine, Charlottesville, VA The Oak Ridge Conference Scientific Program Committee (American Association for Clinical Chemistry) Organizer and co-host with Dr. Robert Carey, Third International Meeting on Peripheral Dopamine, Charlottesville, VA Chairman, Symposium on Laboratory Automation National Meeting of the American Association of Clinical Chemistry The University of Virginia Radiation Safety Committee GRANTS: A. Current Grant Support: 1. National Heart Lung and Blood Institute (NHLBI), Dopamine and Angiotensin Receptor Interactions in Genetic Hypertension, (Program Project Grant, $10,200,000) 2. STTR, National Institutes of Health, In-Home Monitoring of Selected Independent ADLs (Medical Robotics LLC, $150,000) 3. STTR, National Institutes of Health, High Productivity Eukaryotic Cell Culture Technology, (Global Cell Solutions LLC, $99,500) 4. National Institutes of Health, co-principal investigator, Dopamine 1 Receptor Defect in Hypertension ($280,000 subcontract to UVA) 5. University of Virginia Medical Center, Charlottesville, VA, support for Clinical Services B. Previous Grant Support: 1. Armed Forces Institute of Pathology, Motion Study ($6700) 2. Benefactor gift for ElderCare Project ($100,000) 3. BioPhile Inc., Charlottesville, VA, subcontract of Carilion Biomedical Institute 4. Virginia Tech, Blacksburg, VA, Self-Assembling Materials Robot with Control Software ($67,240) 5. National Institutes of Health, R01-HL62252, Principal Investigator, Minority Supplement to Gene Mutations in Human Hypertension ($200,083) 6. North Shore Long Island Jewish Health System, Long Island, NY, Development of an Automated Bio-Repository ($233,750) plus $240,00 equipment loan 7. Gene Mutations in Human Hypertension ($1,393,453) 8.Tech, Carilion Biomedical Institute and University of Virginia ($5,000,000) 8. Tecan, Durham, NC, Robotic Automation of DNA Extraction ($50,000) and loan of a Genesis Robot 9. Abbott, Clinical Trials of the FE-5000 Sample Processor ($40,000) plus $400,000 equipment loan and a $150,000 discount on the purchase

1992 1991 1989 - 1992 1989 1989 1987 - 1993

2004 ­ 2009 2004 ­ 2005 2004 - 2005 2001 ­ 2005 1995 - 2005 2004 2003 2001 ­ 2002 2001 2000 ­ 2003 2000 - 2001 1999 - 2003 1999 ­ 2003 1999 ­ 2000

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of the FE-500 10. Organon Teknika, Raleigh, NC, Robotic Automation of the MDA Coagulation Instrument ($72,000) 11. Helpmate Robotics Inc., Danbury, CT, Simulation of Robotic Fleets in Medical Centers ($18,564) 12. Organon Teknika, Raleigh, NC, Robotic Automation of NASBA ($52,080) 13. Acuity, Nashua, NH, Machine Vision for Medical Specimen Inspection, ($13,500) 14. Abbott Laboratories, Abbott Park, IL, Robotic Interface for the AxSym Immunoassay Instrument ($68,000) 15. NexStar Pharmaceuticals, Boulder, CO, Robotic Automation of Aptamer Production ($100,000) 16. Organon Teknika, Raleigh, NC, Robotic Automation of NASBA QRS Reader ($22,400) 17. National Institutes of Health, RO1-DK39308, co-principal investigator Dopamine-1 Receptor Defect in Hypertension ($430,000 subcontract to UVA) 18. Acuity, Nashua, NH, Investigation of Data Matrix Code in the Clinical Laboratory, PO#94159GL ($7,820) 19. Dupont, Canada, Clinical Evaluation of the Axial Separator System ($10,978) 20. Coulter Corporation and Johnson and Johnson Corporation Automation of Central-Receiving and Processing ($44,000 salary support) 21. Zambon Group (Pharmaceutical Company), Dopamine Receptors in Juxtaglomerular Cell, ($64,000) 22. Dupont, Canada, Axial Separation at Point-of-Care ($8,556) 23. Gilson Electronics Robotic Specimen Aliquotting ($8,000) 24. California Computer Research Inc., Mobile Robots in the Clinical Laboratory ($8,000) 25. Boehringer Mannheim, startup support for projects within Medical Automation Research Center, Machine Vision in the Clinical Laboratory I ($24,980), Machine Vision II ($25,527), Robotic Carryover Detection ($6825) 26. Fogarty International Fellowship ($29,000) 27. National Institutes of Health, RO1-DK39308, co-principal investigator, Dopamine 1 Receptor Defect in Hypertension ($280,000 to UVA) 28. Hamilton Inc., Robotic Automation of Radioligand Binding ($20,000) 29. National Institutes of Health, NIH-R29-DK42185-01, Principal Investigator, Renal Tubular Dopaminergic Mechanisms in Hypertension ($350,000) 30. Baxter Laboratories, Alphafetoprotein ($51,937) 31. Kurume University, Japan, salary support for Postdoctoral Trainee (Keizou Ohbu) ($26,000) 32. Hybritech, Alphafetoprotein ($13,570) 33. Kurume University, Japan, salary support for Postdoctoral Trainee

1999 1997 - 2000 1997 1997 1997 1997 1997 1997 1996 ­ 2001 1996 1995 - 1996 1995 - 1996 1995 ­ 1996 1995 ­ 1996 1994 - 1996 1994 - 1996

1994 - 1996 1992 - 1993 1991 - 1995 1991 - 1992 1989 - 1995 1989 ­ 1990 1989 - 1990 1988 - 1989

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(Shohei Kinoshita) ($22,000) 1987 - 1989 34. Hybritech, Creatine Kinase MB ($13,000) 35. National Institutes of Health, RO1-DK39308, co-principal investigator, Dopamine - 1 Receptor Defect in Hypertension ($325,000, $191,000 to UVA) 1987 - 1990 36. Perkin Elmer, Robotic Automation of Clinical Laboratories ($60,000, equipment and services) 1986 - 1989 37. Hybritech, Alphafetoprotein ($13,975) 1986 ­ 1987 38. National Institutes of Health, subcontract of NIH-HL-14380 P.I.: Jean Robillard ($10,000) 1986 - 1987 39. American Heart Association, subcontract of Hemodynamic and Hormonal Mechanisms in Ureteral Obstruction, P.I.: Bob Chevalier ($1872) 1986 - 1987 40. Roche Diagnostics, Investigation of Carcinoembryonic Antigen in Nonmalignant Disease ($6275) 1985 41. National Institutes of Health, co-principal investigator, RFA# NIH-NHLBI-DHUD-94-G-I, Dopaminergic Control of Blood Pressure ($471,330) 1984 - 1989 42. BRSG, University of Virginia #5,S07, RR05431,23 ($9500) 1984 - 1985 43. National Kidney Foundations, National Capital Area ($12,950) 1983 - 1984 44. BRSG, Georgetown University ($5600) 1983 ­ 1984 CURRENT TRAINEES: 1. David Mack, Doctoral Program, BioMedical Engineering Implementation of design technologies 2. Matt Wolfe, undergraduate, Civil Engineering, SmartHouse 3. Craig Lorie, Electrical Engineering Ph.D. candidate 4. Junichi Yatabe, M.D., Ph.D. 5. Midori Sasaki, M.D., Ph.D. PREVIOUS TRAINEES: 1. Shohei Kinoshita, M.D., Pediatric Nephrologist Kurume University School of Medicine, Kurume, Japan; trained as postdoctoral fellow in renal research 2. Keizou Ohbu, M.D., Ph.D., Pediatric Nephrologist Kurume University School of Medicine, Kurume, Japan; trained as postdoctoral fellow in renal research 3. Randy Turner, University of Virginia, Co-mentor for Ph.D. in Mechanical Engineering 4. Ikuyo Yamaguchi, M.D., Ph.D., Pediatric Nephrologist Kurume University School of Medicine, Kurume, Japan 5. John Taylor, University of Virginia - Computer Science Project director for research machine vision in the Clinical Laboratory 6. Chris Estey, University of Virginia, Co-mentor for M.S., Ph.D. in Biomedical Engineering 7. Georg Hoffman, M.D., internist and lab automation specialist 8. Bin Wu, University of Virginia Department of Computer Science

2002 - present 2002 - present 2003 ­ present 2003 - present 2004 - present

1987 - 1989 1989 - 1991 1990 - 1996 1991 - 1995 1993 - 1994 1994 - 2003 1995 - 2001 1995 - 1999

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9. Hironobu Sanada, MD, Ph.D., Fukushima Medical College 10. John Canterbury, Undergraduate, Engineering major 11. Jamie Sullivan, Undergraduate Engineering major at Carnegie Mellon University (summers) 12. Amit Kumar, Master Degree in Systems Engineering, Co-mentor on Mobile Robot Project 13. Kevin Bowman, Anna Lopez, Undergraduate Engineering major Optimization of Mobile Robot Delivery Project 14. Anna Lopez, undergraduate, Engineering, optimization of Mobile Robot Delivery project 15. Sonya Munson, Undergraduate Computer Science Major, Design and implementation of an automated centrifuge 16. Hidetsuna Watanabe, M.D., Ph.D. Postdoctoral Fellow; Genes for Human Hypertension 17. Janakan Thiagarajay, undergraduate, Engineering 18. Chikh Bengra, Ph.D., Fellow 19. Elle Kovarikova, undergraduate, Computer Science, electronic automation 20. Tim Reynolds, high school student, cryogenic shipping (summers) 21. Danny Cohen, high school student, MARC website maintenance improvement and development 22. Sun Quach, high school student (summers), MARC website maintenance 23. Christopher Mifflin, Undergraduate, (summers) Design and Implementation of Medical Automation Information Web site 24. Jonathan Axisa, Undergraduate, Design of a Lab Simulator Website 25. Andrew Koert, Undergraduate, Mechanical Engineering Automated modeling of biorepository 26. Brian Cooley, graduate student, Computer Science, SmartHouse 27. Sarah Silberblatt, undergraduate, Virginia Tech, Biology (summer) 28. Emily Evans, graduate student, Computer Science, SmartHouse data analysis 29. Shota Sasaki, Doctoral Program, Internal Medicine 30. James Wang, Ph.D. graduate student, BioMedical Engineering Development of software/hardware algorithms for shared control mobility aids 31. Amit Naidu, graduate student, Computer Science, SmartHouse 32. Joe Bosworth, Ph.D. Program, Electrical Engineering Computer vision software development for automated for microscopy analysis 33. Andrea Hallman, undergraduate, Computer Science, co-mentored with Bill Holman (Sr. Engineer/MARC) 34. Sarah Wood, UVA master's degree program, education 35. Aaron Hullman, graduate student, Darden Graduate School of Business and UVA School of Law (joint degree program), Hypogen formation and business plan 36. Stuart Marshall, undergraduate student, Mechanical Engineering, automated modeling of biorepository

1995 - 1998 1996 - 1997 1997 - 1999 1997 - 1998 1997 - 1998 1997 - 1998 1998 - 1999 1999 - 2000 1999 - 2001 2000 - 2003 2000 - 2001 2000 - 2002 2000 - 2003 2000 - 2002 2001 - 2003 2001 2001 2001 2001 2001 - 2002 2001 - 2003 2001 - 2003 2001 - 2002 2001 - 2002 2001 - 2002 2001 - 2003 2001 - 2003 2002 - 2003

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37. Rachel Dada, undergraduate student, Pre-Med, basic science hypertension research 38. Yong Ma, graduate student, Electrical Engineering, SmartHouse, SmartHouse walker design 39. Tracy Barger, graduate student, Systems Engineering, SmartHouse data evaluation 40. Cheryl Valentine, graduate student, Darden Graduate School of Business Administration, SmartHouse business plan 41. Valentin Stefan, graduate student, Darden Graduate School of Business Administration, SmartHouse business plan 42. Florentina Marinescu, graduate student, Darden Graduate School of Business Administration SmartHouse business plan 43. Denise Galbraith, high school student, basic research ­ bead technology (summers) 44. Michael Torok, Biochemistry graduate student enrolled in the Ph.D. program 45. Julie Graves, graduate student, Darden Graduate School of Business Administration 46. Junichi Yatabe, M.D., research fellow in training 47. Ferezana Hashmi, graduate of Darden Business School, and UVA Law School 48. Vijay Rao, Biomedical Engineering Ph.D. candidate 49. Amy Thompson, UVA BIS Program, Medical Safety Project

2002 2002 - 2003 2002 - 2003 2002 2002 - 2003 2002 2002 2003 2003 2003 2003 2003 ­ 2004 2003 - present

PUBLICATIONS IN REFEREED JOURNALS: 1. Colon AR, Felder RA, Ryan TM. Macroamylasemia. J Pediatr 96(1):64-66, January 1980. 2. 3. 4. Felder RA, Calcagno PL, Eisner GM, Jose PA. Ontogeny of myocardial adrenoceptors II. Alpha adrenoceptors. Pediatr Res 16(5):340-342, May 1982. Felder RA, Pelayo JC, Calcagno PL, Eisner GM, Jose PA. Alpha-adrenoceptors in the developing kidney. Pediatr Res 17(2):177-180, February 1983. Felder RA, Blecher MB, Eisner GM, Jose PA. Cortical tubular and glomerular dopamine receptors in the rat kidney. Am J Physiol (Renal Fluid Electrolyte Physiol 15) 246(5 Pt 2):F557-F568, May 1984. Felder RA, Blecher N, Calcagno PL, Jose PA. Dopamine receptors in the proximal tubule of the rabbit. Am J Physiol (Renal Fluid Electrolyte Physiol 16) 247(3 Pt 2):F499-F505, September 1984. Mifflin TE, Bruns DE, Wrotnowski U, Macmillan RH, Stallings RG, Felder RA, Herold DA. Univerity of Virginia case conference. Macroamylase, macro creatine kinase, and other macroenzymes. Clin Chem 31(10):1743-1748, October 1985. Felder RA, Mifflin TE, Bastani B. An optimized method for measuring cyclosporin A with

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I-labeled cyclosporin. Clin Chem 32(7):1378-1382, July 1986.

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Jose PA. Felder RA, Holloway RR, Eisner GM. Dopamine receptors modulate sodium excretion in denervated kidney. Am J Physiol (Renal Fluid Electrolyte Physiol 19) 250(6 Pt 2):F1033-F1038, June 1986. Cote TE, Felder RA, Kebabian JW, Sekura RD, Reisine T, Affolter HU. D-2 dopamine receptor-mediated inhibition of pro-opiomelanocortin synthesis in rat intermediate lobe: Abolition by pertussis toxin or activators of adenylate cyclase. J Biol Chem 261(10):45554561, April 1986. Beaulieu M, Felder RA, Kebabian JW. D-2 dopaminergic agonists and adenosine 3', 5'-monophosphate directly regulate the synthesis of -melanocyte-stimulating hormonelike peptides by cultured rat melanotrophs. Endocrinol 118(3):1032-1039, March 1986. Nakamura KT, Felder RA, Jose PA, Robillard JE. Effects of dopamine in the renal vascular bed of fetal, newborn, and adult sheep. Am J Physiol (Regulatory Integrative Comp Physiol 21) 252(3 Pt 2):R490-R497, March 1987. Felder RA, Macmillan RH, Bruns DE. Two monoclonal-based assays for carcinoembryonic antigen compared. Clin Chem 33(5):700-704, May 1987. Felder RA, Nakamura KT, Robillard JE, Kanadjian M, Jose PA. Dopamine receptors in the developing sheep kidney. Pediatr Nephrol 2(1):156-162, January 1988. Hughes JM, Ragsdale NV, Felder RA, Chevalier RL, King B, Carey RM. Diuresis and natriuresis during continuous dopamine-1 receptor stimulation. Hyperten Suppl 11(2 Pt 2):I169-I174, February 1988. Felder RA, Seikaly MG, Eisner GM, Jose PA. Renal dopamine-1 defect in spontaneous hypertension. Contrib to Nephrol 67:71-74, 1988. Felder RA, Jose PA. Dopamine-1 receptors in the rat kidneys identified with 125I-Sch 23982. Am J Physiol (Renal Fluid Electrolyte Physiol 24) 255(5 Pt 2):F970-F976, November 1988. Siragy HM, Felder RA, Howell NE, Chevalier RL, Peach MJ, Carey RM. Intrarenal dopamine-1 receptors control renal function. Trans Assoc Am Physicians 101:288-291, 1988. Siragy HM, Felder RA, Howell NE, Chevalier RL, Peach MJ, Carey RM. Intrarenal dopamine acts at the dopamine-1 receptor to control renal function. J Hypertens Suppl 6(4):S479-S481, December 1988. Felder RA, Holl RW, Martha P, Bauler G, Hellman P, Wills MR, Thorner MO. Influence of matrix on concentrations of somatotropin measured in serum with commercial immunoradiometric assays. Clin Chem 35(7):1423-1426, July 1989.

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Felder RA, Garland DS. POMC biosynthesis in the intermediate lobe of the spontaneously hypertensive rats. Am J Hypertens 2(8):618-624, August 1989. Siragy HM, Felder RA, Howell NL, Chevalier RL, Peach MJ, Carey RM. Evidence that intrarenal dopamine acts as a paracrine substance at the renal tubule. Am J Physiol (Renal Fluid Electrolyte Physiol 26) 257(3 Pt 2):F469-F477, September 1989. Kinter M, Singh T, Felder RA. Quantitation of selective dopaminergic drugs in plasma by gas chromatography-mass spectrometry following solid-phase extraction. J Chromatog 496(1):201-208, November 1989. Kinoshita S, Sidhu A, Felder RA. Defective dopamine-1 receptor adenylate cyclase coupling in the proximal convoluted tubule from the spontaneously hypertensive rat. J Clin Invest 84(6):1849-1856, December 1989. Kinoshita S, Ohlstein EH, Felder RA. Dopamine-1 receptors in the rat proximal convoluted tubule: regulation by intrarenal dopamine. Am J Physiol (Renal Fluid Electrolyte Physiol 27) 258(4 Pt 2):F1068-F1074, April 1990. Ragsdale NV, Lynd M, Chevalier RL, Felder RA, Peach MJ, Carey RM. Selective peripheral dopamine-1 receptor stimulation: Differential responses to sodium loading and depletion in humans. Hypertens 15(6 Pt 2):914-921, June 1990. Sidhu A, Felder RA, Jose PA, Fishman PH. Comparison of the central and renal dopamine-1 receptor. Am J Hypertens 3(6 Pt 2):37S-39S, June 1990. Carey RM, Siragy HM, Ragsdale NV, Howell NL, Felder RA, Peach MJ, Chevalier RL. Dopamine-1 and dopamine-2 mechanisms in the control of renal function. Am J Hypertens 3(6 Pt 2):59S-63S, June 1990. Felder RA, Kinoshita S, Sidhu A, Ohbu K, Kaskel FJ. A renal dopamine-1 receptor defect in two genetic models of hypertension. Am J Hypertens 3(6 Pt 2):96S-99S, June 1990. Siragy HM, Felder RA, Howell NL, Chevalier RL, Peach MJ, Carey RM. Evidence that dopamine-2 mechanisms control renal function. Am J Physiol (Renal Fluid Electrolyte Physiol 28) 259(5 Pt 2):F793-F800, November 1990. Felder RA, Seikaly MG, Cody P, Eisner GM, Jose PA. Attenuated renal response to dopaminergic drugs in spontaneously hypertensive rats. Hypertens 15(6 Pt 1):560-569, June 1990. Kinoshita S, Felder R. Ontogeny of DA1 receptor-adenylate cyclase coupling in proximal convoluted tubules. Am J Physiol (Renal Fluid Electrolyte Physiol) 259(6 Pt 2):F971-F976, December 1990.

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Felder RA, Vancampen M. Differential modulation of the renal proximal tubular DA-1 receptor by Gpp(NH)p and sodium in the spontaneously hypertensive rat. J Auton Pharmacol 10 Suppl 1:s61-s65, 1990. Bateman BG, Nunley WC Jr., Kolp LA, Kitchin JD III, Felder RA. Vaginal sonography findings and hCG dynamics of early intrauterine and tubal pregnancies. Obstet Gynecol 75(3 Pt 1):421-427, March 1990. Bogart MH, Felder RA, Best RG, Bradley L, Butts W, Crandall B, MacMahon W, Wians FH, Loeh PV. Prospective evaluation of maternal serum human chorionic gonadotropin levels in 3428 pregnancies. Am J Obstet Gynecol 165(3):663-667, September 1991. Cloney DL, Gray RW, Bruns ME, Burnett SH, Smith ML, Felder RA, Bruns DE. Intestinal vitamin D-dependent calbindin-D9k and alkaline phosphatase in spontaneously hypertensive rats. Am J Physiol (Gastrointest Liver Physiol 23) 260(5 Pt 1):G691-G697, May 1991. Ohbu K, Felder, RA. DA1 dopamine receptors in renal cortical collecting duct. Am J Physiol (Renal Fluid Electrolyte Physiol 30) 261(5 Pt 2):F890-F895, November 1991. Siragy HM, Felder RA, Peach MJ, Carey RM. Intrarenal DA2 receptor stimulation in the conscious dog. Am J Physiol (Renal Fluid Electrolyte Physiol 31) 262(6 Pt 2):F932-F938, June 1992. Sidhu A, Vachvanichsanong P, Jose PA, Felder RA. Persistent defective coupling of dopamine-1 receptors to G proteins after solubilization from kidney proximal tubules of hypertensive rats. J Clin Invest 89(3):789-793, March 1992. Horiuchi A, Albrecht FE, Eisner GM, Jose PA, Felder RA. Renal dopamine receptors and pre- and post-cAMP mediated Na+ transport defect in spontaneously hypertensive rats. Am J Physiol (Renal Fluid Electrolyte Physiol 32) 263(6 Pt 2):F1105-F1111, December 1992. Bateman BG, Kolp LA, Nunley WC, Felder RA, Burkett B. Subclinical pregnancy loss in clomiphene citrate-treated women. Fertil Steril 57(1):25-27, January 1992. Jose PA, Raymond JR, Bates MD, Aperia A, Felder RA, Carey RM. The renal dopamine receptors. J Am Soc Nephrol 2(8):1265-1278, February 1992. Ohbu K, Hendley ED, Yamaguchi I, Felder RA. Renal dopamine-1 receptors in hypertensive inbred rat strains with and without hyperactivity. Hypertens 21(4):485-490, April 1993. Felder RA, Kinoshita S, Ohbu K, Mouradian MM, Sibley DR, Monsma FJ Jr, Minowa T, Minowa MT, Canessa LM, Jose PA. Organ specificity of the dopamine-1 receptor/adenylyl cyclase coupling defect in spontaneously hypertensive rats. Am J Physiol (Regulatory Integrative Comp Physiol 33) 264(4 Pt 2):R726-R732, April 1993. Yamaguchi I, Jose PA, Mouradian MM, Canessa LM, Monsma FJ, Sibley DR, Takeyasu K,

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Felder RA. Expression of dopamine D1A receptor gene in proximal tubule of rat kidneys. Am J Physiol (Renal Fluid Electrolyte Physiol 33) 264(2 Pt 2):F280-F285, February 1993. 45. Horiuchi A, Takeyasu K, Mouradian MM, Jose PA, Felder RA. D1A dopamine receptor stimulation inhibits Na+/K+-ATPase activity through protein kinase A. Mol Pharmacol 43(2):281-285, February 1993. Guillery EN, Porter CC, Page WV, Jose PA, Felder RA, Robillard JE. Developmental regulation of the 1B-adrenoceptor in the sheep kidney. Pediatr Res 34(2):124-128, August 1993. Ohbu K, Felder RA. Nephron specificity of dopamine receptor-adenylyl cyclase defect in spontaneous hypertension. Am J Physiol (Renal Fluid Electrolyte Physiol 33) 264(2 Pt 2):F274-F279, February 1993. Eisner GM, Yamaguchi I, Felder RA, Asico LD, Jose PA. Role of renal dopamine D1 receptors in natriuresis induced by calcium channel blockers. Am J Physiol (Renal Fluid Electrolyte Physiol 36) 267(6 Pt 2):F965-F970, December 1994. Ohbu K, Kaskel FJ, Kinoshita S, Felder RA. Dopamine-1 receptors in the proximal convoluted tubule of Dahl rats: defective coupling to adenylate cyclase. Am J Physiol (Regulatory Integrative Comp Physiol 37) 268(1 Pt 2):R231-R235, June 1995. O'Connell DP, Botkin SJ, Romas SJ, Sibley DR, Araino MA, Felder RA, Carey RM. Localization of dopamine DIA receptor in the rat kidneys. Am J Physiol (Renal Fluid Electrolyte Physiol 37) 268(6 Pt 2): F1185-F1197, June 1995. Canessa LM, Piccio MM, Vachvanichsanong P, Sidhu A, Robillard JE, Felder RA, Jose PA. -1B-adrenergic receptors in rat renal microvessels. Kidney Int 48(5):1412-1419, November 1995. Muchant DG, Thornhill BA, Belmonte DC, Felder RA, Baertschi A, Chevalier RL. Chronic sodium loading augments natriuretic response to acute volume expansion in the preweaned rat. Am J Physiol 269(1 Pt 2):R15-R22, July 1995. Yamaguchi I, Walk SF, Jose PA, Felder RA. Dopamine D2L receptors stimulate Na+-K+ATPase activity in murine LTK- cells. Mol Pharmacol 49(2):373-378, February 1996. Jose PA, Eisner GM, Drago J, Carey RM, Felder RA. Dopamine receptor signaling defects in spontaneous hypertension. Am J Hypertens 9(4 Pt 1):400-405, April 1996. Ozono R, O'Connell DP, Vaughan C, Botkin SJ, Walk SF, Felder RA, Carey RM. Expression of the subtype 1A dopamine receptor in the rat heart. Hypertens 27(3 Pt 2):693703, March 1996. Albrecht FE, Drago J, Felder RA, Printz MP, Eisner GM, Robillard JE, Sibley DR, Westphal

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HJ, Jose PA. Role of the D1A dopamine receptor in the pathogenesis of genetic hypertension. J Clin Invest 97(10):2283-2288, May 1996. 57. Yu PY, Eisner GM, Yamaguchi I, Mouradian MM, Felder RA, Jose PA. Dopamine D1A receptor regulation of phospholipase C isoform. J Biol Chem 271(32):19503-19508, August 1996. Horiuchi A, Felder RA. High-level expression of rat D1A dopamine receptor cDNA in mouse fibroblast LTK¯ cells by n-butyrate. Clin Exp Pharmacol Physiol 23(2):150-154, February 1996. Jose PA, Drago J, Accili D, Eisner GM, Felder RA. Transgenic mice to study the role of dopamine receptors in cardiovascular function. Clin Exp Hypertens 19(1-2):15-25, January/February 1997. Sanada H, Yao L, Jose PA, Carey RM, Felder RA. Dopamine D3 receptors in rat juxtaglomerular cells. Clin Exp Hypertens 19(1-2):93-105, January/February 1997. Wang ZQ, Siragy HM, Felder RA, Carey RM. Preferential release of renal dopamine into the tubule lumen: effect of chronic sodium loading. Clin Exp Hypertens 19(1-2):107-116, January/February 1997. O'Connell DP, Ragsdale NV, Boyd DG, Felder RA, Cary RM. Differential human renal tubular responses to dopamine type 1 receptor stimulation are determined by blood pressure status. Hypertens 29(1 Pt 1):115-122, January 1997. Wang ZQ, Siragy HM, Felder RA, Carey RM. Intrarenal dopamine production and distribution in the rat: Physiological control of sodium excretion. Hypertens 29(1 Pt 2):228234, January 1997. Yamaguchi I, Yao L, Sanada H, Ozono R, Mouradian MM, Jose PA, Carey RM, Felder RA. Dopamine D1A receptors and renin release in rat juxtaglomerular cells. Hypertens 29(4):962968, April 1997. Ozono R, O'Connell DP, Wang ZQ, Moore AF, Sanada H, Felder RA, Carey RM. Localization of the dopamine D1 receptor protein in the human heart and kidney. Hypertens 30(3 Pt 2):725-729, September 1997. O'Connell DP, Aherne AM, Lane E, Felder RA, Carey RM. Detection of dopamine receptor D1A subtype-specific mRNA in rat kidney by in situ amplification. Am J Physiol (1 Part 2) (Renal Physiol 43) 274:F232-F241, January 1998. Asico LD, Ladines C, Fuchs S, Accili D, Carey RM, Semeraro C, Pocchiari F, Felder RA, Eisner GM, Jose PA. Disruption of the dopamine D3 receptor gene produces renindependent hypertension. J Clin Invest 102(3):493-498, August 1998.

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O'Connell DP, Vaughn CJ, Aherne AM, Botkin SJ, Wang ZQ, Felder RA, Carey RM. Expression of the dopamine D3 receptor protein in rat kidney. Hypertens 32(5):886-895, November 1998. Jose PA, Asico LD, Eisner GM, Pocchiari F, Semeraro C, Felder RA. Effects of costimulation of dopamine D1- and D2-like receptors on renal function. Am J Physiol 275(4 Pt 2):R986-94, October 1998. Carey RM, Wang ZQ, Siragy HM, Felder RA. Renal dopamine production and release in the rat: a microdialysis study. Adv Pharmacol 42:873-876, 1998. Sanada H, Jose PA, Hazen-Martin D, Yu PY, Xhu J, Bruns DE, Phipps J, Carey RM, Felder RA. Dopamine-1 receptor coupling defect in renal proximal tubular cells in hypertension. Hypertens 33(4):1036-1042, April 1999. Wang ZQ, Felder RA, Carey RM. Selective inhibition of the renal dopamine subtype D1A receptor induces antinatriuresis in conscious rats. Hypertens 33(Pt 2):504-510, January 1999. Sanada H, Asico LD, Shigetomi S, Tanaka K, Niimura S, Watanabe H, Goldstein S, Felder RA. The effect of docarpamine, a dopamine pro-drug, on blood pressure and catecholamine levels in spontaneously hypertensive rats. Clin Exp Hypertens 22(4):419-429, May 2000. Williams SM, Addy JH, Phillips JA, Dai M, Kpodonu J, Afful J, Jackson H, Joseph K, Eason F, Murray MM, Epperson P, Aduonum A, Wong LJ, Jose PA, Felder RA. Combinations of variations in multiple genes are associated with hypertension. Hypertens 36(1):2-6, July 2000. Yu P, Asico LD, Eisner GM, Hopfer U, Felder RA, Jose PA. Renal protein phosphatase 2A activity and spontaneous hypertension in rats. Hypertens 36(6):1053-1058, December 2000. Lao YS, Hendley ED, Felder RA, Jose PA. Elevated renal cortical calmodulin-dependent protein kinase activity and blood pressure. Clin Exp Hypertens 24(4):289-300, May 2002. Felder RA, Sanada H, Xu J, Yu PY, Wang Z, Watanabe H, Asico LD, Wang W, Zheng S, Yamaguchi I, Williams SM, Gainer J, Brown NJ, Hazen-Martin D, Wong LJ, Robillard JE, Carey RM, Eisner GM, Jose PA. G protein-coupled receptor kinase 4 gene variants in human essential hypertension. Proc Natl Acad Sci USA 99(6):3872-3877, March 2002. Watanabe H, Xu J, Bengra C, Jose PA, Felder RA. Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4. Kidney Int 62(3):790-798, September 2002. Bengra C, Mifflin TE, Khripin Y, Manunta P, Williams SM, Jose PA, Felder RA. Genotyping of essential hypertension single-nucleotide polymorphisms by a homogeneous PCR method with universal energy transfer primers. Clin Chem 48(12):2131-2140, December 2002.

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Zheng S, Yu P, Zeng C, Wang Z, Yang Z, Andrews PM, Felder RA, Jose PA. G12- and G13-protein subunit linkage of D5 dopamine receptors in the nephron. Hypertens 41(3):604610, March 2003. Zeng C, Asico LD, Wang X, Hopfer U, Eisner GM, Felder RA, Jose PA. Angiotensin II regulation of AT1 and D3 dopamine receptors in renal proximal tubule cells of SHR. Hypertens 41(3 Pt 2):724-729, March 2003. Zeng C, Luo Y, Asico LD, Hopfer U, Eisner GM, Felder RA, Jose PA. Perturbation of D1 dopamine and AT1 receptor interaction in spontaneously hypertensive rats. Hypertens 42(4 Part 2):787-792, October 2003. Jose PA, Eisner GM, Felder RA. Regulation of blood pressure by dopamine receptors. Nephron Physiol 95(2):19-27, 2003. Sasaki S, Siragy HM, Gildea JJ, Felder RA, Carey RM. Production and role of extracellular guanosine cyclic 3', 5' monophosphate in sodium uptake in human proximal tubule cells. Hypertens 43(2):286-291, February 2004. Jin XH, McGrath HE, Gildea JJ, Siragy HM, Felder RA, Carey RM. Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-naturiuresis via protein kinase G. Hypertens 43(5):1133-1139, May 2004. Zeng C, Wang D, Yang Z, Wang Z, Asico LD, Wilcox CS, Eisner GM, Welch WJ, Felder RA, Jose PA. Dopamine D1 receptor augmentation of D3 receptor action in rat aortic or mesenteric vascular smooth muscles. Hypertens 43(3):673-679, March 2004. Zeng C, Wang D, Asico LD, Welch WJ, Wilcox CS, Hopfer U, Eisner GM, Felder RA, Jose PA. Aberrant D1 and D3 dopamine receptor transregulation in hypertension. Hypertens 43(3):654-660, March 2004. Yang Z, Yu P, Asico LD, Felder RA, Jose PA. Protein phosphatase 2a B56 during development in the spontaneously hypertensive rat. Clin Exp Hypertens 26(3):243-254, April 2004. Williams SM, Ritchie MD, Phillips JA 3rd, Dawson E, Prince M, Dzhura E, Willis A, Semenya A, Summar M, White BC, Addy JH, Kpodonu J, Wong LJ, Felder RA, Jose PA, Moore JH. Multilocus analysis of hypertension: a hierarchical approach. Hum Hered 57(1):28-38, 2004. Zeng C, Sanada H, Watanabe H, Eisner GM, Felder RA, Jose PA. Functional genomics of the dopaminergic system in hypertension. Physiol Genom 19(3):233-246, November 2004. Yu P, Yang Z, Jones JE, Wang Z, Owens SA, Mueller SC, Felder RA, Jose PA. D1 dopamine receptor signaling involves caveolin-2 in HEK-293 cells. Kidney Int 66(6):2167-2180, December 2004.

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Yang Z, Asico LD, Yu P, Wang Z, Jones JE, Bai R, Sibley DR, Felder RA, Jose PA. D5 dopamine receptor regulation of phospholipase D. Am J Physiol Heart Circ Physiol 288(1):H55-H61, January 2005. Zeng C, Yang Z, Wang Z, Jones J, Wang X, Altea J, Mangrum AJ, Hopfer U, Sibley DR, Eisner GM, Felder RA, Jose PA. Interaction of angiotensin II type 1 and D5 dopamine receptors in renal proximal tubule cells. Hypertens 45:1-7, February 2005. Lohmueller KE, Wong LJC, Mauney MM, Jiang L, Felder RA, Jose PA, Williams SM. Patterns of Genetic Variation in the Hypertension Candidate Gene GRK4: Ethnic Variation and Haplotype Structure. Annals of Human Genetics, 2005. Yoneda M, Sanada H, Yatabe J, Midorikawa S, Hashimoto S, Sasaki M, Katoh T, Watanabe T, Andrews PM, Jose PA, Felder RA. Differential effects of angiotensin II type-1 receptor antisense oligonucleotides on renal function in spontaneously hypertensive rats. Hypertens 46(1):58-65, July 2005.

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ROBOTICS AND AUTOMATION PEER REVIEW JOURNALS: 1. Boyd JC, Felder RA, Margrey KS, Martinez A., Savory J. Use of a robotic arm for specimen handling in a remote, unmanned clinical chemistry laboratory. Clin Chem 33(9):1560-1561, 1987. 2. 3. 4. 5. Margrey KS, Martinez A, Vaughan DP, Felder RA. A standard clinical instrument interface for robotic applications. Clin Chem 36(9):1572-1575, September 1990. Felder RA. Clinical laboratory robotics in the 1990s. Chemometrics & Intelligent Laboratory Systems: Lab Info Man 17:111-118, 1992. Holman JW, Felder RA. Robotic automation of cyclosporin analysis in whole blood. Clin Chem 38(8 Pt 1):1440-1443, August 1992. Herold CD, Andree K, Herold D, Felder RA. Robotic chromatography: development and evaluation of automated instrumentation for assay of glycohemoglobin. Clin Chem 39(1):143147, January 1993. Felder RA, Savory J, Margrey KS, Holman JW, Boyd JC. Development of a robotic near patient testing laboratory. Arch Pathol Lab Med 119(10):948-951, October 1995. Felder RA. Robotics and automated workstations for rapid response testing. Am J Clin Pathol 104 (4 Suppl 1):S26-S32, October 1995. Estey CA, Felder RA. Clinical trials of a novel centrifugation technique: axial separation. Clin Chem 42(3):402-409, March 1996.

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Boyd JC, Felder RA, Savory J. Robotics and the changing face of the clinical laboratory. Clin Chem 42(12):1901-1910, December 1996. Felder RA. Transporting with mobile robots. LAN 1(4):6-12, October 1996. Estey CA, Felder RA. Clinical Evaluation of serial blood processing at point of care. Clin Chem 43(2):360-362, February 1997. Felder RA. How to automate your clinical laboratory. J Lab Med 21(4):238-241, 1997 (In German). Felder RA. Modular laboratory robotics and automation. JIFCC 9(2):56, 58-60, 1997. Felder RA, Kost GJ. Modular stepwise automation and the future of diagnostic testing. (Part 1) MLO 30(4):22-24, 26-27, April 1998. Kost GJ, Felder RA. Modular stepwise automation and the future of diagnostic testing. (Part 2) MLO 30(6):46, 48, 56, June 1998. Graves S, Holman B, Rossetti M, Estey C, Felder RA. Robotic automation of coagulation analysis. Clinica Chemica Acta 278(2):269-279, December 1998. Mifflin TE, Felder RA. Development of simple devices for control of temperature above and below ambient on simple pipetting stations. JALA 3(2):38-42, May 1998. Felder RA. Modular workcells: Modern methods for laboratory automation. Clin Chem Acta 278(2):257-267, December 1998. Felder RA. Immunoassay automation. J Clin Lig Assay 22(1):13-24, Spring 1999. Felder RA, Graves S, Mifflin T. Reading the future: The increased relevance of laboratory medicine in the next century. MLO 31(7):20-1, 24-6, July 1999. Felder RA. Small robots for medium-sized hospitals. Biochimica Clinica 23(5):317-319, 1999. Felder RA. Getting specimens from here to there. CAP Today, p34-35, September 1999. Felder R. A new automation tool for medicinal and combinatorial chemists. JALA 4(6):46-47, December 1999. Rosetti MD, Kumar A, Felder RA. Simulation of robotic courier deliveries in hospital distribution services. Health Care Man Science 3(3):201-213, June 2000. Mifflin TE, Estey CA, Felder RA. Robotic automation performs a nested RT-PCR analysis for HCV without introducing sample contamination. Clin Chem Acta 290(2):199-211, January

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2000. 26. 27. 28. 29. 30. 31. 32. 33. 34. Graves S, Holman B, Felder RA. Modular robotic workcell for coagulation analysis. Clin Chem 46(5):772-777, May 2000. Landers L, Timoney CF, Felder RA. Medical mobile robotics: An industry update. JALA 5(3):26-29, July 2000. Gregersen PK, Felder RA. Searching for gene-environment interactions in cancer. JALA 5(5):37-39, November 2000. Graves BS, Mifflin TE, Gunderson J, Geddy S, Kell S, Felder RA. Software implementation of biological repository for human genetic material. JALA 5(6):106-108, December 2000. Wasson G, Gunderson J, Graves S, Felder RA. Effective shared control in cooperative mobility aids. FLAIRS, AAAI p509-513, 2000. Wasson G, Gunderson J, Graves S, Felder RA. An assistive robotic agent for pedestrian mobility. Agents 2001:169-173, May/June 2001. Timoney C, DiLorenzo ME, Felder RA. Pioneers in industrial automation solutions. JALA 6(1):49-51, March 2001. DiLorenzo ME, Timoney CF, Felder RA. Technological advancements in liquid handling robotics. JALA 6(2):36-40, May 2001. Timoney CF, Estey CA, DiLorenzo ME, Felder RA. The life sciences revolution: Creating the tools for a new world ­ an in-depth look at IBM life sciences solutions. JALA 6(3):34-37, July 2001. Felder RA. Conquering the diversity of the human proteome: GeneProt. JALA 6(4):62-64, September 2001. Mifflin TE, Graves SB, Felder RA. A large-scale robotic storage and retrieval system (Biorepository) capable of fully automated operation. Am Genom Proteom Tech 1(3):27-31, November 2001. Silberblatt S, Felder RA, Mifflin TE. Optimizing reaction conditions of the NanoOrange protein quantitation method for use with microplate-based automation. JALA 6(6):83-88, December 2001. Holman JW, Mifflin TE, Demers LM, Felder RA. Evaluation of an automated preanalytical robotic workstation at two academic health centers. Clin Chem 48(3):540-548, March 2002. Kempner ME, Felder RA. A review of cell culture automation. JALA 7(2):56-62, April/May 2002.

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Kempner ME, Timoney CF, Felder RA. Developments in microplate automation. JALA 7(2):67-72, April/May 2002. Felder RA, Kempner ME, Timoney CF. Breaking new ground among the giants. JALA 7(3):44-49, June/July 2002. Felder RA. Automated storage and retrieval at ­80ºC: Managing and documenting specimen security, integrity, and accessibility. Am Lab 35(1):22-25, January 2003. Felder RA. Medical automation: A technologically enhanced work environment to reduce the burden of care on nursing staff and a solution to the health care cost crisis. Nurs Outlook 51(3):S5-S10, May-June 2003.

REVIEW ARTICLES: 1. Felder, RA. Symposium Explores New Approaches to Clinical Laboratory Automation. Clin Chem News 20(4):11, 13, April 1994. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. Jose PA, Eisner GM, Felder RA. Regulation of D1 receptor function in spontaneous hypertension. Adv Pharmacol 42:525-528, 1998. Jose PA, Eisner GM, Felder RA. Role of dopamine in the pathogenesis of hypertension. Clin Exp Pharmacol Physiol Suppl 26:S10-S13, April 1999. Felder RA, Eisner Gm, Jose PA. D1 Dopamine receptor signaling defect in spontaneous hypertension. Acta Physiol Scand 168(1):245-250, January 2000. Jose PA, Eisner GM, Felder RA. Renal dopamine and sodium homeostasis. Curr Hypertens Rep 2(2):174-183, April 2000. Jose PA, Bek MJ, Eisner GM, Felder RA. Dopamine receptors in hypertension. Curr Con Hypertens (Am Soc Hypertens) 4(1):4-5, June 2000. Bek MJ, Eisner GM, Felder RA, Jose PA. Grand Rounds: Dopamine receptors in hypertension. Mt Sinai J Med 68(6):362-369, November 2001. Jose PA, Eisner GM, Felder RA. Role of dopamine receptors in the kidney in the regulation of blood pressure. Curr Opin Nephrol Hypertens 11(1):87-92, January 2002. Jose PA, Eisner GM, Felder RA. Dopamine receptor-coupling defect in hypertension. Curr Hypertens Rep 4(3):237-244, June 2002. Jose PA, Eisner GM, Felder RA. Dopamine and the kidney: role in hypertension? Curr Opin Nephrol Hypertens 12(2):189-194, March 2003. Zeng C, Eisner GM, Felder RA, Jose PA. Dopamine receptor and hypertension. Curr Med

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Chem Cardiovasc Hematol Agents 3(1):69-77, January 2005. BOOK CHAPTERS: 1. Jose PA, Pelayo JC, Felder RA, Tavani N, Montgomery SB, Calcagno PL, Eisner GM. "Maturation of Single-Nephron Filtration Rate in the Canine Puppy - Effects of Saline Loading" in The Kidney During Development: Morphology and Function. Spitzer A (Ed), Masson Pub USA (Ch 18:139-146) 1982. 2. Boyd JC, Savory MG, Felder RA, Bray R, Burns K, Bruns DE. "Measurement of Human Chorionic Gonadotrophin" in Manual of Procedures for Seminar on the Clinical Pathology of Reproduction. Sunderman FW (Ed), Institute for Clinical Science, Philadelphia PA (p151-160) 1984. Felder RA, Jose PA. "Development of Adrenergic and Dopamine Receptors in the Kidney" in Homeostasis, Nephrotoxicity and Renal Anomalies in the Newborn. Strauss J (Ed), MartinusNijhoff, The Hague, Boston MA (p3-10) 1986. Jose PA, Felder RA, Fildes RD, Eisner GM, Calcagno PL. "Renal Handling of Sodium During Development" in Homeostasis, Nephrotoxicity, and Renal Anomalies in the Newborn. Strauss J (Ed), Martinus-Nijhoff, The Hague, Boston MA (p17-22) 1986. Felder RA, Carey RM. "Dopamine in Cardiovascular Function" in Brain Peptides and Catecholamines in Cardiovascular Regulation. Buckley JP, Ferrario CM (Eds), Raven Press, New York (p79-91) 1987. Felder RA, Felder CC, Eisner GM, Jose PA. "Renal Dopamine Receptors" in Peripheral Actions of Dopamine. McGrath B, Bell C (Eds), MacMillan Press, London (Ch 8:124-140) 1988. Felder RA, Boyd JC, Savory J, Margrey KS, Vaughan DP, Martinez A. "Robotics in Clinical Laboratory Medicine" in Automation and New Technology in the Clinical Laboratory. Okuda K (Ed), Blackwell Scientific Publications, Oxford (p87-92) 1990. Felder RA, Margrey K, Vaughan D, Roberts J, Boyd J, Savory J. "Robots in Laboratory Medicine" in Advances in Laboratory Automation ­ Robotics. Strimaitis J (Ed), Zymark Inc., Hopkinton MA, (p381-393) 1990. Jose PA, Felder RA. "Clinical Testing and Evaluation of Glomerular Function" in Clinical Evaluation of Renal Disease in Children. Barakat AY (Ed), Springer-Verlag, New York (p7183) 1990. Boyd JC, Felder RA, Savory J, Margrey KS, Martinez A, Vaughan, D. "Critical Care Testing Using Unmanned Robotic Facilities" in Automation and New Technology in the Clinical Laboratory. Okuda K (Ed), Blackwell Scientific Publications, Oxford (p93-96) 1990. Felder RA, Hamilton M, Geary W. "The Potential Applications of an Androgenic Receptor

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Assay for Anabolic Steroid Screening" in Drugs in Competitive Athletics. Shipe JR, Savory J (Ed), Blackwell Scientific Publications, Oxford UK (p39-45) 1991. 12. Felder RA. "Robotic Automation of HPLC Laboratories" in HPLC in the Pharmaceutical Industry, Vol 47. Fong GW, Lam SK (Eds), Marcel Dekker Inc., New York (Ch 9:185-210) 1991. Jose PA, Martin GR, Felder RA. "Cardiovascular and Autonomic Influences on Blood Pressure" in Pediatric Hypertension. Loggie JMH (Ed), Blackwell Scientific Publications, London (Ch 3:33-51) 1992. Jose PA, Felder RA. "Renal Nerves" in Pediatric Nephrology. Edelmann CM Jr (Ed), Little Brown and Co., Boston MA, 2nd Edition (Ch 12:297-325) 1992. Jose PA, Felder RA, Monsma FJ Jr, Sibley DR, Mouradian MM. "Molecular Biology of Dopamine Receptors: An overview" in Advances in the Biosciences: Cardiovascular and Renal Actions of Dopamine. Pergamon Press, Oxford (88:51-61) 1993. Felder RA, Yamaguchi I, Horiuchi A, Jose PA, Carey RM. "A Molecular Approach to the Study of Renal Dopamine Receptors in Hypertension" in Advances in Biosciences: Cardiovascular and Renal Actions of Dopamine. Pergamon Press, Oxford (88:155-164) 1993. Felder RA. "Overview and Challenges" in Handbook of Clinical Laboratory Automation and Robotics. Kost GJ (Ed), Wiley and Sons Publishers, New York, NY, Part I (Ch 1:3-29) 1996. Felder RA. "Automation of Preanalytical Processing and Mobile Robotics" in Handbook of Clinical Laboratory Automation and Robotics. Kost GJ (Ed), Wiley and Sons Publishers, New York NY (Ch 12:252-282) 1996. Felder RA. "Robotic Automation of Near-Patient Testing" in Handbook of Clinical Laboratory Automation and Robotics. Kost GJ (Ed), Wiley and Sons Publishers, New York, NY (Ch 24:596-619) 1996. Jose PA, Felder RA, Eisner GM. "Regulation of D1 Receptor Function in Spontaneous Hypertension" in Catecholamines: Bridging Basic Science with Clinical Medicine. Goldstein D (Ed), Academic Press, San Diego CA (p525-528) 1997. Felder RA. "The Distributed Laboratory: Point-of-Care Services with Core Laboratory Management" in Point of Care Testing. Hicks J, Price C (Eds), Clinical Chemistry Press, Washington DC (Ch 5:99-118) 1999. Jose PA, Eisner GM, Felder RA. "Dopaminergic Mechanisms in the Development of Hypertension" in Handbook of Hypertension: Development of the Hypertensive Phenotype: Basic and Clinical Studies, Vol 19. Birkenhager WH, Reed JL (Eds), Elsevier Science BV, Amsterdam (Ch 1:1-44) 1999.

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Jose PA, Eisner GM, Felder RA. "Paracrine Regulation of Renal Function by Dopamine" in The Kidney: Physiology and Pathophysiology, 3rd Edition, Seldin DW, Giebisch G (Eds), Lippincott-Raven Publishers, PA (Ch 36:915-930) 2000. Mifflin TE, Kramer G, Hamilton S, Felder RA. "Automation and Robotics in Genomics Laboratories" in Genomic Technologies: Present and Future. Galas DJ, McCormack SJ, (Eds), Caister Academic Press, UK (Ch 10:313-343) 2002. Boyd JC, Felder RA. "Pre-Analytical Automation in the Clinical Laboratory" in Clinical Diagnostic Technology: The Total Testing Process, Vol 1. Ward-Cook K, Lehmann C, Schoeff L, Williams RH (Eds), AACC Press, Washington DC (Ch 7:107-129) 2003.

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INVITED ARTICLES: 1. Savory J, Bertholf RL, Boyd JC, Bruns DE, Felder RA, Lovell MA, Shipe JR, Wills MR, Czaban JD, Coffey KF, O'Connell KM. Advances in clinical chemistry over the past 25 years. Anal Chim Acta 180:99-135, 1986. 2. 3. 4. 5. 6. 7. 8. 9. Felder RA. Lab researches robotics potential. Clin Chem News 12:28-30, 1986. Felder RA, Boyd JC, Savory J. Robots in the clinical laboratory. Med Lab Practice 2:18-19, 1987. Felder RA, Boyd JC, Savory J. Robotics are coming to the critical care laboratory. Canad Clin Lab 7:14, 1988. Felder RA, Seikaly MG, Eisner GM, Jose PA. Renal dopamine-1 defect in spontaneous hypertension. Contrib Nephrol 67:71-74, 1988. Felder RA, Boyd JC, Margrey KS, Martinez A, Vaughan DP, Savory J. Robots the mechanical medical technologist. Clin Chem Endocrinol Metab 7:7-21, 1988. Felder RA, Boyd JC, Savory J, Margrey KS, Martinez A, Vaughan D. Robotics in the clinical laboratory. Clin Lab Med 8(4):699-711, December 1988. Felder RA, Robillard JE, Eisner GM, Jose PA. Role of endogenous dopamine on sodium excretion. Sem Nephrol 9(1):91-93, March 1989. Felder RA, Felder CC, Eisner GM, Jose, PA. The dopamine receptor in adult and maturing kidney. Am J Physiol (Renal Fluid Electrolyte Physiol 26) 257(3 Pt 2):F315-F327, September 1989. Felder RA, Boyd JC, Margrey K, Holman W, Savory J. Robotics in the medical laboratory. Clin Chem 36(9):1534-1543, September 1990. Carey RM, Siragy HM, Felder RA. Physiological modulation of renal function by the renal dopaminergic system. J Auton Pharmacol 10 Suppl 1:s47-s51, 1990.

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Jose PA, Felder RA, Felder CC, Chan WY. Molecular biology of adrenergic and dopamine receptors and the study of developmental nephrology. Pediatr Nephrol 4(6):679-685, November 1990. Felder RA, Boyd JC, Savory J. Clinical laboratory robots ­ their impact on laboratory management. Clin Lab Manage Rev 4(6):449-454, November/December 1990. Felder RA, Holman W, Boyd JC, Savory J, Margrey K. Clinical laboratory robotics in the 1990s. Adv Lab Autom - Robotics 7:787-801, 1991. Felder RA, Boyd JC, Margery KS, Holman W, Roberts J, Savory J. Robots in health care. Anal Chem 63(14):741A-747A, July 1991. Felder RA. Laboratory systems integration: robotics and automation. Ann Biol Clin (Paris) 49(5):298-300, 1991. Felder RA. Recent advances in clinical laboratory robotics. Scientific Bavaria '92, 4th International Symposium: Progress in Laboratory Diagnostics, Schloss Elmau, Germany, Jp;ze; W. L;pse S (Eds), Urban & Vogel, Muncher, p109-133, October 1992. Felder R, Turner R. Radioligand Binding Assays. Packard Instrument Company, Matrix Application Note, p1-5, July 1992. Jose PA, Eisner GM, Felder RA. Dopaminergic defect in hypertension. Pediatr Nephrol 7(6):859-864, December 1993. Herold CD, Holman JW, Andree K, Felder RA, Herold DA. Development and evaluation of a robotics-based system for glycoslyated hemoglobin analysis. Chemometrics and Intelligent Laboratory Systems: Lab Inform Man 21:189-197, 1993. Felder RA. Robotic technology presents challenges and opportunities to laboratories. Chemometrics and Intelligent Laboratory Systems: Lab Inform Man 26(2):67-68, November 1994. Felder RA. ICAR '94: Robot technology applied to the laboratory. Monitor/Laboratory Information Management 26:56-59, 1994. Felder RA, Person NB. Front-End Systems: The Next Automation Wave. Advance for Administrators of the Laboratory 4(7):16-17, 20, 22-23, 26, July/August 1995. Jose, PA, Yu P-Y, Yamaguchi I, Eisner GM, Mouradian MM, Felder CC, Felder RA. Dopamine D1 receptor regulation of phospholipase C. Hypertens Res ­ Clin Exper 18 Suppl 1:S39-S42, June 1995. Yamaguchi I, Walk SF, Felder RA. Studying the dopaminergic system with transfected

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receptors. Hypertens Res ­ Clin Exper 18(Suppl)1:S19-S22, June 1995. 27. 28. Turner R, Felder RA, Kealy M. Automation of the Polymerase Chain Reaction. Am Biotech Lab 13(12):50-51, November 1995. Jose PA, Felder RA. What we can learn from the selective manipulation of dopaminergic receptors about the pathogenesis and treatment of hypertension. Curr Opin Nephr Hypertens 5(5):447-51, September 1996. Felder RA. Laboratory Automation: Strategies and Possibilities. Clin Lab News (Part I) 22(3):10-11, March 1996. Felder RA. Cost-Justifying Laboratory Automation. Clin Lab News (Part II) 22(4):10-11, 17, April 1996. Felder RA. Maybe `Star Wars' Wasn't So Far Off. Advance 5(8):121, August 1996. Felder RA. Laboratory Robotics and Automation Conference '96: Clinical laboratory applications. Am Clin Lab 15(10):20, November/December 1996. Felder RA. ICAR '96 Conference Highlights. LAN 1(2):11-16, March 1996. Felder RA. Laboratory Automation: Real Cost Justification Data. AdvAdmin Lab 5(7):22-23, 26, 30-31, July 1996. Grandsard P, Felder R. ICAR '96 Conference Highlights ­ Part 3. LAN 1(4):14-18, October 1996. Felder RA. Lab Automation, Artificial Intelligence Highlights of. Adv Admin Lab 5(11):19, November 1996. Grandsard P, Felder R. Laboratory Robotics and Automation Conference '96: Analytical, Environmental, and Pharmaceutical Applications. Am Lab 15(10):22, 24, December 1996. Felder RA. Total, Modular Lab Automation Helps Reach Efficiency Targets. Adv Med Lab Prof 8(15):6-7, July 1996. Estey CA, Jagger J, Felder RA. Studies show plastic specimen tubes viable, safe option. Advance (Cover story), 9(5):5-7, March 1997. Felder RA. Automation: innovative and inevitable. A commentary. Clin Lab Man Rev 11(6):365-367, November/December 1997. Felder RA. Summary of LabAutomation'97, clinical presentations. Am Clin Lab 16(7):18, 1997.

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Felder RA. High-throughput screening and other applications of laboratory automation from LabAutomation `97. Am Lab 29(21):26, 28, 30, October 1997. Lamb DA, Felder R, McClellan D. As we see it. Prudent use of technology. Clin Lab Mgmt Rev 11(3):192-195, May/June 1997. Felder RA. Lab Automation '97 conference highlights. LAN 2(2):15-25, May 1997. Holman W, Turner R, Felder RA. Automating your existing clinical instruments. LAN 2(3):24-29, July 1997. Felder, RA. TLA has arrived! LAN 2(3):30-31, July 1997. Felder RA, Godolphin W, Estey C, Hoffmann G. LabAutomation'98: New developments in high-throughput screening and combinatorial chemistry. Am Lab 30(13):19-20, June 1998. Felder RA, Godolphin W, Estey C, Hoffman G. LabAutomation'98: new developments in clinical laboratory automation (Part 1). Am Clin Lab 17(6):10, July 1998. Felder RA, Godolphin W, Estey C, Hoffman G. LabAutomation'98 (Part 2): new developments in European clinical laboratory automation and total laboratory automation. Am Clin Lab 17(7):7-9, August 1998. Felder RA, Godolphin W, Estey C, Hoffman G. LabAutomation'98 (Part 3): new hardware and software developments in clinical laboratory automation. Am Clin Lab 17(8):8-9, September 1998. Jose PA, Eisner GM, Felder RA. Renal dopamine receptors in health and hypertension. Pharmacol Ther 80(2):149-182, November 1998. Godolphin W, Estey C, Hoffmann G, Felder R. Review of the LabAutomation'98 conference and exhibition. JALA 3(3):18-21, 23, 26-32, 34, July 1998. Timoney CF, Beugelsdijk TJ, Felder RA. Eurolabautomation'98 at Oxford University. JALA 3(6):85-89, December 1998. Timoney CF, Felder RA. Zymark: A pioneering company in laboratory automation. JALA 3(1):12-16, March 1998. Felder RA. Automation: Survival Tools for the Hospital Laboratory in Proceedings of the Second International Bayer Diagnostics Laboratory Symposium. Balzac F (Ed), New York NY, p23-25, July 1998. Timoney CF, Felder RA. Cepheid: Expanding the boundaries for practical applications of microinstrumentation and microfluidics. JALA 3(6):22-26, December 1998.

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Felder RA. The wonders of laboratory automation. Adv Lab 7(11):38-40, 42-43, November 1998. Felder RA, Abdelmoteleb A. LabAutomation'99 Conference Review. JALA 4(2): 43-50, May 1999. Felder RA. Clinical laboratory automation comes of age: case histories abound at the LabAutomation `99 conference. American Clinical Laboratory, 18(7):6-7, 1999. Felder RA, Graves S, Robertson D, Ferkany D. Modular, step-wise approach to automation. Adv Admin Lab 8(8):72, 74, 76, August 1999. Felder RA. Overview of laboratory automation equipment specifications. CAP Today, September, 1999. Timoney C, Felder RA. Biochip Technology of the Future ­ Today! JALA 4(4):86-89, September 1999. Felder RA, Mifflin T, Graves S. The automation of laboratory medicine. Adv Admin Lab 8(12):37-40, 1999. Felder RA, Timoney C. Review of LabAutomation 2000: clinical session review Part 1 molecular diagnostics and large-scale automation. Am Clin Lab 19(6):16-17, July 2000. Felder RA. Review of LabAutomation 2000: clinical session review Part 2: E-commerce mobile cart, connectivity, and integrated futures. Am Clin Lab 19(7):8-9, August 2000. Felder RA. Review of LabAutomation 2000, case histories. Am Clin Lab 19(8):12-13, 2000. Felder RA. LabAutomation2000. JALA 5(1):32-36, March 2000. Felder RA. LabAutomation2000. JALA 5(2):44-52, May 2000. Timoney CF, Felder RA. Automation solutions: It's all about time. JALA 5(3):32-36, July 2000. Timoney CF, DiLorenzo ME, Felder RA. Research and technology for life. JALA 5(4):52-56, September 2000. Felder RA. Review of LabAutomation 2000, miniaturization, high-speed analysis, and POC data management. Am Clin Lab 19(9):14-15, 2000. Felder RA. ALA and LabAutomation 2000. Am Lab 32(22):44-49, 2000. Timoney CF, Felder RA. Creating practical solutions. JALA 5(6):44-45, December 2000.

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Felder RA. EuroLabAutomation 2000. JALA 5(6):32-42, December 2000. Jose PA, Eisner GM, Felder RA. Renal dopamine and sodium homeostasis. Curr Hypertens Rep 2(2):174-183, April 2000. DiLorenzo ME, Felder RA. LabAutomation2001: Where biotech meets automation. JALA 6(1):34-42, March 2001. Felder RA. Is lab automation right for your lab? CAP Today 15(5):42-44, 46, 48, passim, May 2001. DiLorenzo ME, Timoney CF, Felder RA. LabAutomation 2001, Part I: Experiences with total laboratory automation. Am Clin Lab 20(5):41-43, June 2001. DiLorenzo M