Free Declaration in Support - District Court of California - California

Case 5:08-cv-00133-RMW Document 77 Filed 04/07/2008 I Henry C. Su (SBN 211202; [email protected]) Katharine L. Altemus (SBN 227080; [email protected])

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2 HOWREYLLP
1950 University Avenue, 4th Floor 3 East Palo Alto, California 9430J Telephone: (650) 798-3500 4 Facsimile: (650) 798-3600
5 Robert Ruyak

Matthew Wolf 6 Marc Cohn

HOWREYLLP
7 1229 Pennsylvania Avenue, NW Washington, DC 20004 8 Telephone: (202) 783-0800 Facsimile: (202) 383-6610 9 Attorneys for Plaintiffs 10 HOLOGTC, INC., CYTYC CORP. and HOLOGIC L.P.
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UNITED STATES DIS'rRICT COURT NORTHERN DISTRICT OF CALIFORNIA SAN JOSE DIVISION Case No. C08 00133 RMW (RS)
DECLARATION OF LYNN J. VERHEY, Ph.D. IN SUPPORT OF PLAINTIFFS' MOTION FOR PRELIMINARY INJUNCTION

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14 HOLOGIC, INC., CYTYC CORPORATION, and HOLOGIC L.P., 15 Plaintiffs, 16 vs. 17 SENORX, INC., 18 Defendant. 19/1---

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Date: Apri121,2008 Time: 2:00 p.rn Room: Courtroom 6, 4th Floor Judge: Hon. Ronald M. Whyte

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AND RELATED COUNTERCLAIMS.
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Declaration ofLynn J. Verhe1..,_Ph.D.
Case No. C08-0Q133 RMW (ICS)
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Case 5:08-cv-00133-RMW Document 77 Filed 04/07/2008 I, Lynn 1. Verhey, Ph.D., declare and state as follows:
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I have been retained in this case as an expert witness by Plaintiffs Hologic, Inc., Cytyc

Corporation, and Hologic L.P. I make this declaration based on my personal knowledge, training and

4 experience, and if! were to be called to testify, J could and would testify competently about the subject
5 matter set forth below.

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2.

I am presently employed by the University of California, San Francisco, as a Full

7 Professor and I serve as Vice-Chair in the Department of Radiation Oncology. Attached to this
8 declaration as Exhibit A is a copy of my curriculum vitae.

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3.

To brietly summarize my background and education, T received my B.A. in Physics

10 from Kalamazoo College, Kalamazoo, Michigan in 1962, and my M.S. and Ph.D. in Physics in 1964 11 and 1968, respectively, from the Uni versity of lllinois, Urbana, Illinois. The subject of my research 12 during my education was on the decays of certain charged particles produced by high energy 13 interactions of protons with Hydrogen and Deuterium. 14 4. After earning my doctorate, I took a position at UCLA and served as a post-doctoral

15 researcher and Assistant Professor of Physics from 1968-70, doing experiments at Lawrence Berkeley 16 Laboratory and teaching physics to undergraduate physics students. I then moved to Harvard 17 University in 1970 as an Assistant Professor, continuing to teach undergraduate physics and perform 18 high energy experiments, this time at Fermi National Laboratory in lllinois. 19

5.

In 1975 I took a position as Hospital Radiation Physicist at Massachusetts General

20 Hospital (MGH) with a concurrent- continuing position as Assistant Professor at the Harvard Medic-al 21 22 SchooL 1then worked with the MGH group to develop and implement proton radiation therapy as an alternative to x-ray therapy.

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6.

In 1990, I took the position as Chief of the Physics Division and Associate Professor in

24 the Department of Radiation Oncology at UCSF. Since that time, I have continued to serve as Physics 25 Chief and, in addition, as Vice-Chair of the Department and as a Full Professor. As part of my

26 responsibilities at UCSF. I have mentorcd numerous graduate and post-graduate students, taught 27 graduate classes in the Department of Bioengineering at the University of California, Berkeley as well

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Declaration ofLynn J. Verhey, Ph.D. Case No. C08-00133 RMW (RS)

Filed 04/07/2008 Page of 7 1 as atCase 5:08-cv-00133-RMW physics to medical residents at UCSF as well as to3physics UCSF. I have taught medical Document 77

2 residents. I have performed research on methods of delivering radiation to cancer patients and have
3 published over 100 technical papers in this field. 4

7.

1 was certified as a therapeutic radiological physicist by the American Board of

5 Radiology in 1982, appointed.a fellow of the American Association of Physicists in Medicine in 2002

6 and a fellow of the American Society of Therapeutic Radiology and Oncology in 2006. Tam a well7 recognized expert in methods of delivering radiation to cancer patients, having given numerous 8 scientific lectures and scientific meetings, both nationally and internationally.

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8.

I previously served as an expertwitness for Cytyc Corporation in the case ofXofi, Inc.

10 v, Cytyc Corporation and Proxima Therapeutics, Inc., Case No. C05-05312 RMW, which was also 11 pending in this Court. 1 understand that this case, like the Xofi case, involves claims of infringement of 12 United States Patent Nos. 5,913,813 (the "813 patent") and 6,413,204 (the "204 patent"). J also 13 understand that a third United States Patent, No. 6,482,142 (the "142 patent"), is involved in this case

14 as well.

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9.

In general, the 813 patent describes and claims an invention in the field of a balloon

16 catheter for treatment of proliferative tissue, while the 204 patent extends this concept to describe and 17 claim as an invention a method for treatment of proliferative tissue diseases using an interstitial 18 brachytherapy apparatus. These patents describe a catheter which can be used with an array of 19 radiation-producing materials to irradiate the wall of a surgical cavity and a defined thickness of tissue 20 beyond that wall, to doses that can both avoid necrosis of normal tissue and destroy cancer cells that 21 might populate the area. The 142 patent further extends the concept of the 813 patent to describe and 22 claim balloon catheter devices that are capable of delivering asymmetrically shaped radiation doses. 10. In connection with my role as an expert witness in the Xoft case, I offered this Court the

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24 following definition of a person of ordinary skill in the art, which is applicable here as well given that 25 26 the same family of patents is at issue. In understanding what is taught and claimed in the 813, 204 and 142 patents, the relevant scientific area is radiation oncology physics, with a focus on brachytherapy.

27 Typically, individuals of ordinary skill in the art of this field would hold an M.S. degree in Physics or

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Declaration ofLynn 1. Verhey, Ph.D. Case No. C08-00133 RMW (RS)

1 Engineering, with 3 or more years of clinical medical physics experience; or a Ph.D. degree in Physics 2 or Medical Physics with 2 or more years of clinical experience. 11. Such a person would have a broad knowledge of the physics ofbrachytherapy

Case 5:08-cv-00133-RMW

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4 procedures, of the principles of radioactivity and an understanding of the effects of radiation on cells. 5 In addition, such a person would have an understanding of other means of treating cancer cells with 6 radiation such as an external, gantry-mounted linear accelerator. Individuals with such qualifications 7 are considered eligible for certification as a radiation oncology physicist by entities such as the 8 American Board of Radiology and considered capable of working independently in a clinical 9 environment as a medical physicist. 10 12. I have been asked by Plaintiffs' counsel to describe, from the viewpoint of a person of

11 ordinary skill in the art (as defined above), what is disclosed and taught in two technical documents: 12 (1) a 1990 article entitled "A New Technique of Brachytherapy for Malignant Gliomas with Cesium13 137: A New Method Utilizing a remote Afterloading System," by Ashpole et al (attached as Ex. 5 to 14 the Declaration of Aaron P. Maurer) ("Ashpole"). and (2) U.S. Patent No. 5,931,774 to Williams, et al.

15 (attached as Ex. 13 to the Declaration of Aaron P. Maurer) (the n774 patent"), entitled "Inflatable
16 Devices for Tumor Treatment" which describes "implantable devices for treatment of proliferative

17 disorders." I have been provided with copies of both documents and have reviewed them.
18

13.

Ashpole describes the irradiation of a cavity from which a brain tumor has been

19 removed, using an intracranial applicator made by modifying an endotracheal tube. Tn its unmodified 20 form, the endotracheal tube has an open lumen that provides an unobstructed airway and an inflatable

21 balloon, called a cuff, attached near its distal end that seals the space between the tube and the trachea 22 to prevent the aspiration of unwanted matter from the pharynx. into the trachea. To be used as an 23 24 intracranial applicator, the endotracheal tube is shortened in length and sealed off at its distal end, jU~1 beyond the lower end of the balloon. Page 334, column 1.

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14.

The intracranial applicator is visually inserted into the postsurgical cavity following the

26 removal of the brain tumor. and the balloon is then inflated with a radio-opaque fluid (needed for 27 treatment planning purposes) so that it approximately fills the cavity. The volume of fluid used varies

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Declaration ofLynn J. Verhe)'.~Ph.D. Case No. C08-00133 RMW (RS)

Case 5:08-cv-00133-RMW Document 77 Filed visually prior Page 5 of 7 1 according to the size of the tumor bed and the intlation is done04/07/2008 to site closure. Page 334,
2 column 2. 3

15.

There is no teaching in Ashpole that the balloon can be expanded to conform the shape

4 of the cavity to the outer surface of the balloon, or that the balloon comes into contact with the tumor 5 bed at all points, or that the distance from the tumor bed to the radiation source can be adjusted through 6 expansion of the balloon. Indeed, one of ordinary skill in the art would understand that undue 7 deformation and compression of sensitive normal brain tissue caused by the influx of an 8 incompressible fluid , arc not desirable.

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16.

After the intracranial applicator has been implanted, it is attached to a Selectron remote

10 afterloader, which pushes dummy sources into the tube. using positions which represent potential 11 dwelling points for the radioactive sources during treatment. Ashpole produces a desired mean dose 12 rate at a given distance from the balloon's surface by varying the position of active and inactive beads 13 in the source train until an isodose curve is found, which is a satisfactory match to the cavity shape. In 14 other words, the desired dose distribution is a direct result of the particular arrangement of active and 15 inactive beads on a source train, and Ashpole aims to compute an isodose surface that conforms to the 16 particular shape of the postsurgical cavity, rather than reshaping the cavity to conform to the outer 17 surface of the balloon. Page 336, column 1 ("A certain measure ofdosimetrical versatility is possible 18 in that the positions of the active beads can be changed to produce an isodose distribution specific to 19 the geometry of the individual tumor beds.").

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17.

In Ashpole the configuration of the balloon plays a role only to ensure that the dose at

21 the prescribed depth 01'0.5 em is greater than 50% ofthat at the surface of the balloon. To ensure the 22 minimum ratio, Ashpole teaches that "the balloon diameter should not be less than 2.5 em." Page 336, 23 24 25 column 2. Ashpole does not teach changing the balloon diameter after implantation. Rather, it prescribes a minimum diameter to which a balloon should be inflated with radio-opaque fluid during implantation.

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18.

Ashpole does not disclose controlling the dose at the surface of the balloon so that it is

27 not so high that it lethally damages healthy brain cells in contact with the surface. For instance, it 28
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Case No. COS-00133 RMW (RS)

Declaration of Lynn J. Verhe}:. Ph.D.

Case 5:08-cv-00133-RMW Document 77 Filed 04/07/2008 Page 6 of 7 1 indicates that "[tjhe dose at the surface of the balloon ... can be as high as 70 Gy," notwithstanding

2 the fact that "the limited tolerance of normal brain has restricted the maximum permissible dose to 3 about 55-60 Gy." Page 333, column 2; page 336, column 2. Furthermore, if one applies the inverse
4 square law to Ashpoles "typical case [of] a balloon diameter of2.9 em," then a depth dose of 50Gy at

5 0.5 cm from the surface of the balloon would mean a dose ofapproximatcly 90 Gy at the surface, 6 assuming a symmetric distribution of sources within the balloon. Ashpole' s teaching of a minimum

7 balloon diameter of 2.5 em suggests that for a dose of SOGy at 0.5 em from the cavity surfact, that the
8 dose at the surface can be even higher than 90 Gy.

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19.

Ashpole explains that the intracranial applicator avoids the problem of late or delayed

10 radionecrosis observed with the use of long-term wire implants because the intracranial applicator is 11 removable and implanted into an area from which the tumor has already been debulked. Page 336, 12 column 2. 13 20. The 774 patent discloses an implantable balloon applicator for delivering one or more

14 treatment fluids to target tissue. Although it discusses several embodiments, the one of particular 15 interest is a "double balloon device",with an outer and inner balloon, as depicted in Figure 3.
16

21.

The 774 patent teaches that "it is preferable that the balloon have a shape that permits

17 the balloon to conform to the body cavity or lumen in which the balloon is to be inflated." Column 7, 18 lines 41-43. Furthermore, "[i]n certain embodiments, a balloon will be selected such that, upon 19 intlation, the balloon does not compress the tissue which is being treated, or surrounding tissues. Thus, 20 when a radioactive treatment fluid is introduced into the device, e.g., by injection, the treatment device 21 is inflated to a volume not SUbstantially greater than a volume of the body cavity in which the device 22 has been placed, thereby avoiding any substantial compression or distortion of normal tissue." Column 23 7, lines 48-56. This is consistent with the disclosure in Ash-pole, in which the applicator balloon, 24 because it is being used within the brain, is inflated with fluid to a volume only sufficient to fill the 25 postsurgical cavity in'which the device has been placed but not to cause any compression or 26 deformation of the surrounding brain tissue. 27 28
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Case No. C08-00133 RMW (RS)

Declaration of 'Lynn J. Verhe}',_Ph.O.

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Case 5:08-cv-00133-RMW device of Figure 3 is shown 04/07/2008 treatment of 7 Filed as having two Page 7 fluid 22. The double balloon Document 77

2 receptacles. one in communication with the outer balloon and the other one in communication with the

3 inner balloon. Column 8, lines 41-46 and 54-60. The outer balloon in this example is filled with a 4 chemotherapeutic fluid and the inner balloon is filled with a radioactive fluid. Column 8, lines 60-65.
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23.

Although Figure 3 shows the inner balloon as having an off-center position relative to

6 the outer balloon, this is a schematic view only and not something drawn to scale. Column 3, Jines 17 2. Accordingly, the degree to which the inner balloon occupies an asymmetric position relative to the 8 outer balloon, which is not mentioned or discussed at all in the 774 patent, cannot be determined. It
9 would depend on the device's actual design and construction.

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24.

More importantly, neither Figure 3 nor the specification of the 774 patent teaches a

11 person of ordinary skill in the art how the radiation source in the inner balloon can be locatedand

12 arranged to provide predetermined asymmetric isodose curves relative to the outer balloon. If the
13 inner. balloon has an asymmetry relative to the outer balloon, that asymmetry is fixed by the geometric 14 constraints of the device, and therefore the position of the inner balloon cannot be altered to provide
15 predetermined asymmetric isodose. Instead, any asymmetric dose distribution produced by the

16 radioactive fluid in the inner balloon would be a byproduct of the inner balloon's inherent asymmetry. 17

25.

In addition to the Xoft case mentioned above, for which I provided both deposition and

18 hearing testimony, I provided testimony as an expert at a deposition in the case of Maggiani vs. 19 University ofSouthern California conducted on February 20, 2006.

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26.

I am being compensated for my work on this matter at a rate of $500 per hour. My

21 compensation does not depend on the outcome of this case.
22 1 declare that the foregoing is true and correct to the best of my knowledge under penalty of

23 perjury.

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Executed on April_3- ' 2008 in San Francisco, California

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Declaration ofLynn J. Verhey. Ph.n. Case No. C08·00133 RMW (RS)

TOTAL P.07

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Exhibit A

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Lynn J. Verhey, PhD

University of California, San Francisco CURRICULUM VITAE Name: Position: Lynn J. Verhey Professor in Residence, Step 6 Department of Radiation Oncology School of Medicine Faculty Member, Bioengineering Graduate Group Address: UCSF Comprehensive Cancer Center Suite H-1031, Box 1708 San Francisco, CA 94143-1708 Voice: (415) 353-7184 FAX: (415) 353-7182 email: [email protected] EDUCATION: 1958-62 1962-64 1964-67 Kalamazoo College, Kalamazoo, MI University of Illinois, Urbana, IL University of Illinois, Urbana, IL BA MS PhD

Updated: 5/10/07

Physics, Cum Laude Physics Physics

BOARD CERTIFICATION: 1982 American Board of Radiology (Therapeutic Radiological Physics)

PRINCIPAL POSITIONS HELD: 1967-70 1971-72 1972-75 1975-90 1991-96 1996-now University of California, LA Harvard University Harvard University Harvard Medical School University of California, SF University of California, SF Assistant Professor Lecturer Assistant Professor Assistant Professor Assoc. Professor in Residence Professor in Residence Physics Physics Physics Radiation Therapy Radiation Oncology Radiation Oncology

OTHER POSITIONS HELD CONCURRENTLY: 1975-78 1978-90 1978-90 Massachusetts General Hospital Assistant Biophysicist Radiation Medicine Massachusetts General HospitalAssociate Biophysicist Radiation Medicine Massachusetts General HospitalHead, Clinical Physics Proton Therapy

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Lynn J. Verhey, PhD

1991-now 1991-now 1991-00 1994-now

University of California, SF University of California, SF University of California, SF UCSF and UC Berkeley

Chief of Physics Vice-Chair Faculty Faculty

Radiation Oncology Radiation Oncology Graduate Group in Biophysics Bioengineering Graduate Group

HONORS AND AWARDS: 1962 1962 2002 2006 Phi Beta Kappa, Kalamazoo College John Wesley Hornbeck Prize in Physics, Kalamazoo College, Kalamazoo, MI Fellow, American Association of Physicists in Medicine Fellow, American Society of Therapeutic Radiation and Oncology

KEYWORDS/AREAS OF INTEREST: Radiotherapy, intensity modulation, protons, radiosurgery, ocular melanoma, dosimetry, imageguided radiotherapy, magnetic resonance spectroscopy, cancer of the prostate, head and neck and brain.

PROFESSIONAL ACTIVITIES
CLINICAL: Head of clinical physics from 1978-90 for the proton radiation treatment program of the Department of Radiation Therapy, Massachusetts General Hospital. Director of Physics for Gamma Knife Facility, University of California, San Francisco since 1991 Director of Physics for ocular melanoma proton treatment facility University of California, San Francisco and University of California, Davis since 1994 Implementation and direction of intensity modulated radiotherapy treatments at UCSF since 1997 Specification and oversight for acquisition, installation, commissioning and operation of $20 million state-of-the-art Radiation Oncology Department at UCSF Comprehensive Cancer Center at Mount Zion from 1998 to present SUMMARY OF CLINICAL ACTIVITIES As Chief of Physics in the Department of Radiation Oncology at UCSF, I am responsible for all technical aspects of the planning and delivery of sophisticated precision radiotherapy and radiosurgery. This includes supervision and oversight of approximately 20 radiation therapists, six dosimetrists, two engineers and eight physicists. I provide oversight and direction to the physics faculty in their clinical service and in the development of new clinical delivery schemes and imaging methods. As Director of Physics for the Gamma Knife, I coordinate and oversee quality assurance of treatments, safety and radiation training of all personnel, new upgrades of software and hardware and the installation of new radiation sources.
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Lynn J. Verhey, PhD

PROFESSIONAL ORGANIZATIONS: Memberships 1962 1966 1975-80 1976-now 1979-now 1979-99 1983-90 1984-now 1986-90 1992-now 1995-now 1995-now Phi Beta Kappa Sigma Pi Sigma American Association of Physics Teachers American Association of Physicists in Medicine American Society of Therapeutic Radiologists Radiation Research Society American Association for the Advancement of Science Proton Therapy Cooperative Group New York Academy of Science International Stereotactic Radiosurgery Society California Radiological Society American College of Radiology

Service to Professional Organizations 1991-97 1992-99 1992-97 1992-93 1993-95 1993-now 1993-03 1994 1995-now 1996-01 1996-01 2000-02 2003-now Chairman of Quality Assurance Committee of Proton Radiation OncologyGroup Sponsored by American College of Radiology Member, RTOG Committee on Quality Assurance in Conformal Radiation Therapy (3D-CRT) Member, Radiation Physics Committee of American Society for Therapeutic Radiology and Oncology (ASTRO) Member, Research Committee, American Association of Physicists in Medicine (AAPM) Reviewer for Awards and Honors Committee of AAPM Reviewer of abstracts for Annual meeting of AAPM Reviewer of abstracts for Annual Meeting of ASTRO Reviewer of abstracts for 1994 Annual Meeting of the Radiological Society of North America (RSNA) Member, Committee on Quality Assurance for Cooperative Clinical Trials, a Subcommittee of the Radiation Therapy Committee of the AAPM Member, Committee on Membership of ASTRO Member, 3D Committee of the Radiation Therapy Oncology Group (RTOG) Member, Awards Committee of ASTRO Member, Corporate Working Group of ASTRO

SERVICE TO PROFESSIONAL PUBLICATIONS 1998-now 1988-now Editorial Board, International Journal Radiation Oncology, Biology and Physics (IJROBP) Ad hoc referee for IJROBP (10 papers in past 5 years), Medical Physics (5 papers in past 5 years), British Journal of Radiology (2 papers in past 5 years), Radiotherapy and Oncology (2 papers in past 5 years), Physics in Medicine and Biology (8 papers in past 5 years)
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Lynn J. Verhey, PhD

INVITED PRESENTATIONS (PAST 15 YEARS) INTERNATIONAL 1991 1991 1993 1993 1994 1994 1995 1995 1995 1995 1997 1997 1997 1997 1997 1997 1998 1998 1998 1999 1999 2000 2000 2000 2000 2000 2000 2001 2001 2001 2002 2002 International Workshop on Heavy Charged Particle Therapy and Related Subjects, National Institute for Radiological Sciences, Chiba, Japan World Congress on Medical Physics and Biomedical Engineering, Kyoto, Japan International Leksell Gamma Knife Society Meeting, Aronsborg, Sweden International Symposium on 3D Radiation Treatment Planning and Conformal Therapy, St. Louis, MO Proton Therapy Cooperative Group Meeting, Chester, England Proton Therapy Cooperative Group Meeting, Chiba, Japan Siemens Vision Group on New Directions in Radiotherapy, Frankfurt, Germany Annual Meeting of the International Commission on Radiation Units and Measurements (ICRU) in Remsheid-Lennep, Germany US-Japan Radiation Oncology Meeting, San Francisco, CA International Stereotactic Radiosurgery Meeting, Boston, MA XII International Conference on the Use of Computers in Radiation Therapy, Salt Lake City, Utah First Professor S. Takahashi Memorial International Workshop on Three Dimensional Conformal Radiotherapy, Nagoya, Japan Siemens Therapy Products Enduser Meeting and Seminar, Beijing, China International Congress of Radiation Oncology, Beijing, China Third Congress of the International Stereotactic Radiosurgery Society, Madrid, Spain ESTRO Workshop on Challenges in Conformal Radiotherapy, Nice, France DKFZ (Deutsche Krebs Forschung Zentrum), Heidelberg, Germany 3rd International Symposium on 3-D Radiation Treatment Planning and Conformal Radiotherapy, Chapel Hill, NC Second Professor S. Takahashi Memorial International Workshop on Three Dimensional Conformal Radiotherapy, Nagoya, Japan International Stereotactic Radiosurgery Society (ISRS) Meeting, Sydney, Australia Annual Meting of Societe Francaise De Radiotherapie Oncologique, Paris, France 2nd Annual Wharton Lecture, Princess Margaret Hospital, Toronto, Canada Hallym Hospital, Seoul, Korea Samsung Hospital, Seoul, Korea Addenbrookes Hospital, Cambridge, England Annual Meeting of the European Society for Therapeutic Radiology and Oncology (ESTRO), Istanbul, Turkey First International Symposium on Stereotactically Guided IMRS/IMRT, Los Angeles, CA International Congress on Radiation Oncology (ICRO), Melbourne, Australia Sun-Yat-Sen Cancer Center, Taipei, Taiwan Third Professor S. Takahashi Memorial International Workshop on Three Dimensional Conformal Radiotherapy, Nagoya, Japan Leksell Gamma Knife Society Meeting, Prague, Czech Republic Hospital Sirio Libanes, Sao Paulo, Brazil
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Lynn J. Verhey, PhD

2002 2003 2003 2003 2004 NATIONAL 1992 1993 1994 1995 1995 1995 1996 1996 1997 1997 1998 1998 1998 1999 1999 1999 1999 1999 2000 2000 2000 2000 2001 2001

Joint Meeting Canadian Organization of Medical Physicists and American Association of Medical Physicists, Montreal, Canada NZIMRT Annual Conference, Hamilton, New Zealand Organizer, Moderator and Speaker, 7th International Conference on 3DCRT/IMRT, San Francisco, CA 2nd International Conference on Translational Research and Pre-Clinical Strategies in Radio-Oncology, Lugano, Switzerland Fourth Professor S. Takahashi Memorial International Workshop on Three Dimensional Conformal Radiotherapy, Nagoya, Japan

Special Focus Panel at Annual Meeting of Radiological Society of North America, Chicago, IL: Special Panel on Conformal Therapy at the Annual Meeting of the American Society for Therapeutic Radiation and Oncology, New Orleans, LA Preuss Foundation Seminar on Stereotactic Radiation Treatment of Brain Tumors, Boston MA Special Workshop at the Annual Meeting of the Radiation Research Society on "New Methods of Delivering Radiation Therapy", San Jose, CA Symposium on Implementation of Emergent Technology in Radiation Oncology, Indian Wells, CA Scientific Session of the Radiation Therapy Oncology Group Annual Meeting, Philadelphia, PA Workshop on Intensity Modulated Radiation Therapy, Durango, CO Radiation Therapy Oncology Group Annual Meeting, Washington, DC Visiting Professor, Duke University Medical Center, Department of Radiation Oncology Grand Rounds, Durham, NC 14th Annual Meeting of the American College of Medical Physics, Lake Tahoe, CA 20th Annual Engineering Industrial Liaison Program, University of Calif., Berkeley, CA Intensity Modulated Radiation Therapy Workshop, Williamsburg, VA Annual Meeting of the American Association of Physicists in Medicine (AAPM), San Antonio, TX Radiation Therapy Oncology Group (RTOG) Annual Meeting, Atlanta, GA 3-D Meeting on Conformal and Intensity Modulated Radiation Therapy, Houston, TX Annual Meeting of AAPM, Nashville, TN National Cancer Institute Workshop on Medical Physics for Clinical Radiotherapy, Washington, DC Annual Meeting of the American Association of Therapeutic Radiology and Oncology (ASTRO), San Antonio, TX 3-D Conformal Radiotherapy Workshop, New York, NY Combined Meeting of World Congress of Medical Physicists and AAPM, Chicago, IL Annual Meeting of ASTRO, Boston, MA Siemens Users' Meeting, Kiowah Island, SC International Stereotactic Radiosurgery Society (ISRS), Las Vegas, NM Annual Meeting of AAPM, Salt Lake City, UT

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2001 2002 2002 2003 2003 2003 2004 2004 2004

Visiting Professor, Symposium Honoring the Career of Dr. Michael Goitein at Massachusetts General Hospital, Boston, MA Visiting Professor, Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA Annual Meeting of ASTRO, New Orleans, LA Annual Meeting of ASTRO, Salt Lake City, UT Organizer, Moderator and Speaker, Proton Therapy Cooperative Group Meeting, San Francisco, CA Siemens Users' Meeting, Salt Lake City, UT Annual Meeting of AAPM, Pittsburgh, PA Annual Meeting of ASTRO, Atlanta, GA Annual Meeting of American Association of Physics Teachers, Sacramento, CA

REGIONAL AND OTHER INVITED PRESENTATIONS 1991 1993 1993 1994 1994 1995 1996 1997 1997 1998 1999 1999 2001 2002 2002 2002 2002 2003 Cancer Education Session, Stanford University Department of Radiation Oncology, Stanford, CA Department of Physics, Sonoma State University, Rohnert Park, CA Bay Area Chapter of the American Association of Neuroscience Nurses Grand Rounds, Department of Radiation Oncology, UCSF 29th Annual San Francisco Cancer Symposium, San Francisco, CA 15th Annual Current Approaches to Radiation Oncology, Biology and Physics, San Francisco, CA Northern California Society of Radiation Therapy Technologists, Concord, CA 16th Annual Current Approaches to Radiation Oncology, Biology and Physics, San Francisco, CA Annual Retreat of the Graduate Group in Biophysics, UCSF, Tiburon, CA 17th Annual Current Approaches to Radiation Oncology, Biology and Physics, San Francisco, CA 18th Annual Current Approaches to Radiation Oncology, Biology and Physics, San Francisco, CA First Annual Radiosurgery Symposium, UCSF Stanford University IMRT Symposium, Palo Alto, CA Cyberknife Users' Meeting, Napa, CA Siemens Users' Meeting, Santa Rosa, CA UCSF-Stanford Post-Graduate Course ­ Scientific Program Coordinator and Moderator Joint Meeting of SFSU-UCSF U56 Collaborative Advisory Committee UCSF-Stanford Post-Graduate Course ­ Scientific Program Coordinator and Moderator

GOVERNMENT AND OTHER PROFESSIONAL SERVICE: 1990-97 1990-91 1992-93 Chair, Report Committee on Proton Therapy, International Commission on Radiation Units and Measurements (ICRU) Loma Linda University Medical Center: Safety Review Committee on the Proton Therapy Facility Lawrence Berkeley Laboratory, University of California, Berkeley: Dosimetry Review Committee for Heavy Ion Radiotherapy Program
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1992 1992-93 1993 1993-95 1995 1996 1997-04 1997-01 1999 1999 1999-01 2000 2000-03 2001 2004

Lawrence Berkeley Laboratory, University of California, Berkeley: Research Medicine and Radiation Biophysics Division Review Committee National Cancer Institute: Program Project Scientific Review Panel National Cancer Institute: Review Committee for Radiological Physics Center at M.D. Anderson Hospital, Houston, TX Nuclear Regulatory Commission and Lawrence Livermore National Laboratory: Reviewer of Quality Management Plans TRIUMF and the British Columbia Cancer Agency: Safety Review Committee on the Proton Therapy Facility National Cancer Institute: Member, Special Review Committee for Program Project at University of Michigan Medical Center Takahashi International Workshop Organizing Committee, Nagoya, Japan National Cancer Institute: Member, Special Ad Hoc Review Committee of the Radiation Studies Section of NCI External Physics Consultant to Swedish Hospital, Seattle, WA External Advisor to University of Texas Medical Branch, Galveston, TX National Cancer Institute: Member, Intensity Modulated Radiotherapy Cooperative Working Group National Cancer Institute: Member, Special Review Committee for Program Project at University of Michigan Medical Center Cancer Research Coordinating Committee of State of California: Reviewer of Research Proposals Special Advisor to Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada Special Ad Hoc Reviewer of Research Proposal for the Dutch Cancer Society

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Lynn J. Verhey, PhD

UNIVERSITY AND PUBLIC SERVICE
UNIVERSITY SERVICE: UCSF, UC BERKELEY AND UC DAVIS CAMPUS-WIDE 1991-00 1991-93 1992-03 1992-03 1993-95 1994 1994 1994-now 1997-00 1998,99,02 1998 1998-now 1999 2000-03 2001-now 2001-03 2001-02 2003-now 2002-03 2004Faculty member of the Graduate Group in Biophysics, University of California, San Francisco Member, University of California, Davis Cancer Center Proton Beam Task Force and Clinical Specifications Subcommittee Chair, Radiation Drug Research Committee, University of California, San Francisco Member, Radiation Safety Committee, University of California, San Francisco Member, Environmental Health and Sciences Advisory Group, University of California, San Francisco Chair, Ad Hoc Promotion Review Committee, University of California, San Francisco Founding Member, UCSF Cancer Center Faculty member of Bioengineering Graduate Program, University of California, Berkeley Member, Health and Safety Policy Board of the University of California, San Francisco Member Ad Hoc Promotion Review Committees, University of California, San Francisco Vice-Chair, Admissions Committee of the Bioengineering Graduate Program, University of California, Berkeley Specification and oversight for acquisition, installation, commissioning and operation of $20 M state-of-the-art Radiation Oncology Department at UCSF Comprehensive Cancer Center at Mount Zion Chair, Admissions Committee of the Bioengineering Graduate Program, University of California, Berkeley Member, Graduate Council of the Academic Senate, University of California, San Francisco Member, UCSF Health and Safety Policy Board Member, Bioengineering Graduate Group Executive Committee Member, Academic Senate Subcommittee on Creation of a UCSF School of Advanced Health Studies Member, Bioengineering Graduate Group Advisors' Committee Service on Qualifying and Final Exam Committees for Bioengineering Grad. Students Member, Educational Policy Committee of the Academic Senate, UCSF

DEPARTMENTAL SERVICE 1991-now 1991-now 1991-now 1991-now Vice Chair and Chief of Physics Member, Internal Computer Committee Member, External Computer Committee Member, Program Committee of Annual Course on Current Approaches to Radiation Oncology, Biology and Physics
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1991-94 1991-now 1991-now 1991-now 1991-now 1993-94 1993-now 1996 1997 1997 1998 1998 1998 2001-now

Member, Mt. Zion -University of California, San Francisco Radiation Oncology Integration Committee Member, Quality Assurance / Quality Improvement Committee Member, Radiation Oncology Research Allocation Committee Member, Radiation Oncology Resident Selection Committee Member, Executive Committee of Department of Radiation Oncology Chair, Faculty Search Committee for Physics Faculty in Hyperthermia Initiator and Director, Physics Residency Training Program in Therapeutic Radiation Oncology Physics Member, Faculty Search Committee for Assistant Professor in Residence with Combined Research/Clinical Duties Chair, Ad Hoc Committee for Selection of NOMOS Medical Research Fellow for Clinical Implementation of Intensity Modulated Radiation Therapy Member, Faculty Search Committee for Wun-Kon Fu Endowed Chair in Radiation Oncology Member, Senior Promotions Committee Chair, Ad Hoc Committee for Selection of Siemens Medical Research Fellow Chair, Faculty Search Committee for Assistant Professor in Residence (Physics) Member, Radiation Oncology Animal Care Review Committee

PUBLIC SERVICE: 1990 1993-98 1998 1998 2000-03 2001-04 Member of scientific delegation for US-Soviet Union Proton Therapy Exchange Program Member, Medical Physics Advisory Committee (MEDPAC), Lawrence Livermore National Laboratory Scientific American Interview with W. Wayt Gibbs Wired Magazine Interview with Heidi Kriz Scientific Advisory Board, Accuray, Inc. Scientific Advisory Board, MED-TEC, Inc.

SUMMARY OF SERVICE ACTIVITIES Most of my service activities in the past five years have been associated with administrative duties within the Department of Radiation Oncology, campus-wide committees, and activities within the cross-campus Bioengineering Graduate Group, where I am an active faculty member. As a member of the executive committee of the Department of Radiation Oncology, I am involved in all decisions relating to finances, promotions and salaries, and space allocation. As the Chief of the Physics Division within the department, I have special mentoring and advising duties for the other physics faculty as well as technical supervision of engineers, dosimetrists and radiation therapists. As Director of the Physics Residency Training Program, I have major responsibilities to select, mentor and advise the residents in their clinical training program. As a member of the Medical Residency Selection Committee, I work with a small group of department faculty to interview and rank resident candidates. As a member of the Program Committee of the Annual UCSF-Stanford Post-Graduate Course on Current Approaches to Radiation Oncology, Biology and Physics, I am responsible for planning and arranging the physics and technical presentations. As a long-standing member of the Radiation
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Safety Committee of the campus until 2003, I was one of several members responsible for investigating and analyzing the use of radioactivity in research and in clinical activities. As a member of the Scientific Advisory Board of two vendors of medical equipment used in Radiation Oncology, I have been able to influence the development of devices that improve the quality of patient care.

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TEACHING and MENTORING
FORMAL SCHEDULED CLASSES FOR UCSF AND UCB STUDENTS: Qtr F,W F,W F,W F,W F,W F,W F S S S Acad. Yr 1998-99 1999-00 2000-01 2001-02 2002-03 2003-04 2000-01 2001-02 2003-04 2005-06 Course No. & Title Medicine 424 Therapeutic Radiological Physics Medicine 424 Therapeutic Radiological Physics Medicine 424 Therapeutic Radiological Physics Medicine 424 Therapeutic Radiological Physics Medicine 424 Therapeutic Radiological Physics Medicine 424 Therapeutic Radiological Physics NE 167 Engineering Aspects Nuc Med / RadioTherapy Bioeng. 230C Physics of Radiation Oncology Bioeng 230C Physics of Radiation Oncology Bioeng 230C Physics of Radiation Oncology Contribution Lecturer Lecturer Lecturer Lecturer Lecturer Lecturer Course Design and Lecturer Course Design and Lecturer Course Design and Lecturer Course Design and Lecturer Units 1 1 1 1 1 1 3 3 3 3 Class Size 5 5 5 5 5 5 10 5 8 4

POSTGRADUATE AND OTHER COURSES 2003 2002-05 2002-06 7th International Conference on 3DCRT/IMRT, San Francisco, Organizer, Moderator and Speaker UCSF-Stanford Post-Graduate Course on Radiation Oncology ­ Scientific Program Coordinator, Moderator and Speaker Gamma Knife Model C training for outside clinicians and physicists

PREDOCTORAL STUDENTS SUPERVISED OR MENTORED Dates 1998-99 1998-00 1999-02 Name Nkiruka Emeagwali Gordon Wong Ted Graves Program or School Johns Hopkins Bioengineering, UCB Bioengineering, UCSF
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Role Research advisor Research advisor Research comentor

Current Position Graduate Student Graduate Student Asst. Prof. Stanford

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2000 2001-02 2003200420032002-04 2004-

Andrew Hwang Richard Cardenas Michael Lometti Erica Ludlam Olivier Morin Annette A. Chan Cornelius VonMorze

Bioengineering, UCSF

Rotation coordinator

Graduate Student

Texas Tech University Research co-mentor SFSU MS student Bioengineering, UCSF Research co-mentor Research co-mentor Bioengineering, UCSF Academic advisor Research co-mentor Bioengineering, UCSF Academic advisor Bioengineering, UCSF Academic advisor

Asst Prof St. Marys TX Research co-mentor Research Associate Graduate Student Graduate Student Post-doctoral Researcher Graduate Student

POSTDOCTORAL FELLOWS AND RESIDENTS DIRECTLY SUPERVISED OR MENTORED Dates 1992-95 1993-95 1994-95 1994-98 1994-96 1995-97 1998-00 1996-98 1997-99 1998-00 1999-02 1999-01 2000-03 2000-01 2002-04 2001-02 2002-05 2003-07 Name Su-Min Zhou Bruce Hill Tibor Major Inder Daftari Greg Bednarz Ping Xia Michelle Svatos Jenny Hai D Jay Wieczorek Lei Wang Cynthia Chuang Andrea Pirzkall Katja Langen Khalil Sultanem Jose-Eduardo Villarreal Jean Nakamura Ningsheng Zhu Josephine Chen Fellow/Resident Physics Res. Fellow Physics Resident IAEA Physics Fellow Hospital Physicist Physics Resident Physics Resident Physics Res. Fellow Physics Resident Physics Resident Physics Resident Physics Resident Research Fellow Physics Resident Clinical Fellow Physics Resident Rad. Onc. Resident Physics Resident Research Fellow and Physics Resident
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Faculty Role Research Advisor Clinical Training Research Advisor Clinical Training Clinical Training Clinical Training Research Advisor Clinical Training Clinical Training Clinical Training Clinical Training Research Supervision Clinical Training Research Supervision Clinical Training Research Supervision Clinical Training Research and Clinical Training

Current Position Assoc. Prof. Duke Physicist - Stanford Physicist ­ Hungary Hospital Physicist UCSF Physicist­ U. Penn Assoc. Prof. UCSF Physicist - Siemens Physicist- Stanford Physicist ­ Baptist Hosp. Miami Asst Prof Sequoia Hosp Clin. Instructor UCSF Asst. Adj. Prof. UCSF Physicist ­ MD Anderson Orlando Attending Physician Physicist - Mount Diablo Hospital Instructor, UCSF Physics Resident Research Fellow and Resident

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2003-05 2005-07 2007-09

Hong Chen Martina Descovich Tarek Halabi

Physics Resident Physics Resident Physics Resident

Clinical Training Clinical Training Clinical Training

Physics Resident Physics Resident Physics Resident

RADIATION ONCOLOGY RESIDENTS AND FELLOWS ­ CLINICAL INSTRUCTION 1989-92 Marquez, Carol Bahary, Jean-Paul Uhl, Valerie Stalpers, Lucas Feehan, Patrick Gotkowitz, Carrie Holland, John Goldsmith, Brian Diaz, Aidnag Crownover, Richard Haas-Kogan, Daphne Chou, Rachel Le, Quynh-Thu Seung, Steven Posner, Marc Suplica, Jeffrey Fisch, Ben Sultanem, Khalil Nakamura, Jean Lee Stickney, Eric Ho, Linh Missett, Brian Chen, Allen Lee, Brian Levin, Ken Garwood, Dan Miyawaki, Lloyd Eng, Tony Lillis, Patricia Chang, Garrick Yates, Barbara Schrieve, Dennis Tran, Loan Bermudez, Maria-Amelia Bauman, Glenn Chen, Anita Forstner, Julie Coleman, Cardella Gottschalk, Alex Vigneault, Eric Lee, Terry Young, C. Dale Takamiya, Robert Doyle, Kelly Huang, David Coleman, Joy Dai, Charlotte Stalpers, Lucas Levine, Rene Schoenthaler, Robin Scharfen, Cindy Weil, Michaei Hunter, Darryl Maloney, Alan Ling, Stella Schultz, Marion Koeplin, David Coleman, Lori Shu, Hui-Kuo Song, Joseph Seaward, Samantha Hoffman, Rex Bertucio, Clare Tsao, May Biggs, Christopher Lowther, David Huang, Kim Rembert, James Millender, Laura Hansen, Eric

1992-95 1995-99

1999-01 2001-03

2003-present

INFORMAL TEACHING: 1991-07 1991-07 Teaching Gamma Knife planning to residents, fellows and faculty In-service lectures on radiosurgery, IMRT and clinical physics

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FACULTY MENTORING Dates 1994-96 1998-02 2002-now 2003 2001-04 2006-07 Name Paula Petti Ping Xia Cynthia Chuang Bruce Faddegon Andrea Pirzkall Lijun Ma Position while Mentoring Role Mentored Asst. Academic and research Professor advisor Academic and research Clinical advisor, reviewed grant Instructor proposal Clinical Academic and research Instructor advisor Associate Reviewed grant Professor proposal Assistant Reviewed manuscripts, Researcher academic advisor Associate Reviewed manuscripts Professor and mentored research Current Position Adjunct Professor UCSF Associate Professor in Residence, UCSF Asst. Adjunct Professor, UCSF Associate Professor, UCSF Associate Professor, UCSF Associate Professor, UCSF

SUMMARY OF TEACHING HOURS:

2002-03

305 total hours of teaching (including preparation) Formal class or course teaching hours: 25 hours Informal teaching hours: 250 hours Mentoring: 30 hours 390 total hours of teaching (including preparation) Formal class or course teaching hours: 80 hours Informal teaching hours: 280 hours Mentoring: 30 hours 335 total hours of teaching (including preparation) Formal class or course teaching hours: 30 hours Informal teaching hours: 280 hours Mentoring: 25 hours

2003-04

2004-05

TEACHING NARRATIVE: My teaching hours are divided between formal courses, including a quarter course (Bioengineering 230C) recently introduced by me to offer the Physics of Radiation Oncology as a subject. From this course, several graduate students have become interested in research in the physics of Radiation Oncology and are now doing rotations or beginning thesis research in our group. As director of the Physics Residency Training Program, I have been responsible for designing the curriculum, selecting the residents and assuring their progress through the clinical training. Two of the graduates of this program have stayed to become faculty in our Department. As Chief of Physics, I am responsible for the physics education of the medical residents. I have also taken responsibility for mentoring new faculty in the Physics Division as well as clinical physics instruction for new medical faculty. In summary, it is my responsibility to educate all faculty and staff in the physics of Radiation Oncology.
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RESEARCH AND CREATIVE ACTIVITIES
RESEARCH AWARDS AND GRANTS CURRENT U56 Minority Institution/Cancer Center Partnership Cancer Training and Career Development NIH/NCI (PI: Macher) Siemens ­ UCSF Research Collaborative Agreement Research on Portal Imaging and Intensity Modulation Siemens Oncology Systems (PI: Verhey) PENDING Radiosurgical Treatment of Temporal Lobe Epilepsy NIH/NINDS (PI: Barbaro) PAST R01 NS39280 Radiosurgical Treatment of Temporal Lobe Epilepsy NIH/NINDS (PI: Barbaro) Award for Physics Residency Training Program ASTRO/AAPM (PI: Verhey) 09/30/00-08/31/03 $266,481 direct 09/01/96-08/31/98 $30,000 direct 04/01/02-03/31/07 $2,500,000 direct 10/01/05-09/30/07 $390,000 direct

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PEER REVIEWED PUBLICATIONS 1. Abrams RJ, Abashian A, Mischke RE, Nefkens BMK, Smith JH, Thatcher RC, Verhey LJ, Wattenberg A. Test of time reversal invariance in the decay KL° -> - µ + n. Phys Rev Letters 17:606-608, 1966. Verhey LJ, Nefkens BMK, Abashian A, Abrams RJ, Carpenter DW, Mischke RE, Smith JH, Thatcher RC, Wattenberg A. Experimental investigation of CP violation in Ke3° decays. Phys Rev Letters 17:669-671, 1966. Mischke RE, Abashian A, Abrams RJ, Carpenter DW, Nefkens BMK, Smith JH, Thatcher RC, Verhey LJ, Wattenberg A. Determination of the phase of the CP-nonconservation parameter n+ in neutral K decay. Phys Rev Letters 18:138-141, 1967. Thatcher RC, Abashian A, Abrams RJ, Carpenter DW, Mischke RE, Nefkens BMK, Smith JH, Verhey LJ, Wattenberg A. Upper limit on the decay rate KL° -> +-g Phys Rev. D4:1674-1680, 1968. Abrams RJ, Abashian A, Mischke RE, Nefkens BMK, Smith JH, Thatcher RC, Verhey LJ, Wattenberg A. Muon polarization in K µ3° meson decay. Phys Rev. D5:1603-1615, 1968. Parsons ASL, Truoel P, Berardo PA, Haddock RP, Verhey LJ, Zeller ME. A scintillation counter array for detection of high energy neutrons. Nuc Inst and Methods 79:43-50, 1970. Berardo PA, Haddock RP, Nefkens BMK, Verhey LJ, Zeller ME, Parsons ASL, Truoel P. Measurement of the -p -> gn differential cross section near the roper resonance, P11 (1460). Phys Rev Letters 24:419-422, 1970. Berardo PA, Haddock RP, Nefkens BMK, Verhey LJ, Zeller ME, Parsons ASL, Truoel P. Measurement of inverse pion photoproduction near the P33° (1236) resonance. Phys Rev Letters 26:201-204, 1971. Berardo PA, Haddock RP, Helland J, Nefkens BMK, Verhey LJ, Zeller ME, Parsons ASL, Truoel P. Analysis of negative pion photoproduction near the P33 resonance: test of the I < 1 rule and T-reversal invariance. Phys Rev Letters 26:205-208, 1971. Berardo PA, Haddock RP, Nefkens BMK, Verhey LJ, Zeller ME, Parsons ASL, Truoel P. A measurement of the differential cross-section -P -> n °. Phys Rev D6:756-766, 1972. Berardo PA, Haddock RP, Nefkens BMK, Verhey LJ, Zeller ME, Parsons ASL, Truoel P. Differential cross-sections of -p -> gn for 317, 452 and 491 MeV/c incident pion momentum. Phys Rev. D9:621-643, 1974. Comiso JC, Blasberg DJ, Haddock RP, Nefkens BMK, Truoel P, Verhey LJ. Inverse pion photoproduction in the vicinity of the P33 (1232) resonance and a test of time reversal invariance. Phys Rev. D12:719-737, 1975. Comiso JC, Blasberg DJ, Haddock RP, Nefkens BMK, Truoel P, Verhey LJ. Differential cross-section measurements of -p -> °n around the P33 (1232) resonance. Phys. Rev. D12:738-743, 1975. Loomis WA, Matis HS, Anderson HL, Bharadwaj VK, Booth NE, Fine RM, Francis WR, Gordon BA, Heisterberg RH, Hicks RG, Kirk TBW, Kirkbride GI, Mo LW, Myrianthopoulos LC, Pipkin RM, Pordes SH, Quirk SC. Inclusive hadron production in inelastic muon-proton scattering at 150 GeV/c. Phys Rev Letters 35:1483, 1975.

2.

3. 4.

5. 6. 7.

8.

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10. 11.

12.

13.

14.

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15. 16.

17.

18. 19.

20.

21. 22. 23. 24. 25. 26. 27.

Weiss AJ, Blasberg DJ, Comiso JC, Haddock RP, Nefkens BMK, Verhey LJ, Zeller MB, Crowe KM, Fainberg A, Truoel P. Measurement of differential cross-sections for radiative pion-proton capture in the second resonance region. Nuc Phys. B101:1-18, 1975. Anderson HL, Bharadwaj VK, Booth NE, Fine RM, Francis WR, Gordon BA, Heisterberg RH, Hicks RG, Kirk TBW, Kirkbride GI, Loomis WA, Matis HS, Mo LW, Myrianthopoulos LC, Pipkin FM, Pordes SH, Quirk SW, Shambroom WD, Skuja A, Verhey LJ, Williams WSC, Wilson R, Wright SC. Properties of inclusive hadron spectra in muonnucleon scattering at 150 GeV/c. Phys Rev Letters 36:1422-1425, 1976. Anderson HL, Bharadwaj VK, Booth NE, Fine RM, Francis WR, Gordon BA, Heisterberg RH, Hicks RG, Kirk TBW, Kirkbride GI, Loomis WA, Matis HS, Mo LW, Myrianthopoulos LC, Pipkin FM, Pordes SH, Quirk TW, Shambroom WD, Skuja A, Verhey LJ, Williams WSC, Wilson R, Wright SC. Measurement of nucleon structure function in muon scattering at 147 GeV/c. Phys Rev Letters 37:4-7, 1976. Gragoudas ES, Goitein M, Koehler AM, Verhey LJ, Tepper J, Suit HD, Brockhurst R, Constable IJ. Proton irradiation of small choroidal malignant melanomas. Am J Ophthalmol. 83:665-673, 1977. Francis WR, Anderson HL, Bharadwaj VK, Booth NE, Fine RM, Gordon BA, Heisterberg RH, Hicks RG, Kirk TBW, Kirkbride GI, Loomis WA, Matis HS, Mo LW, Myrianthopoulos LC, Pipkin FM, Pordes SH, Quirk TW, Shambroom WD, Skuja A, Verhey LJ, Williams WSC, Wilson R, Wright SC. Diffractive production of mesons by 147GeV muons. Phys Rev Letters 38:633-636, 1977. Anderson HL, Bharadwaj VK, Booth NE, Fine RM, Francis WR, Gordon BA, Heisterberg RH, Hicks RG, Kirk TBW, Kirkbride GI, Loomis WA, Matis HS, Mo LW, Myrianthopoulos LC, Pipkin FM, Pordes SH, Quirk TW, Shambroom WD, Skuja A, Staton MA, Williams WSC, Verhey LJ, Wilson R, Wright SC. Measurement of the proton structure function from muon scattering. Phys Rev Letters 38:1450-1454, 1977. Tepper J, Verhey L, Goitein M, Suit HD, Koehler AM. In vivo determinations of RBE in a high energy modulated proton beam using normal tissue reactions and fractionated dose schedules. Int J Radiat Oncol Biol Phys. 2:1115-1122, 1977. Suit H, Goitein M, Tepper J, Verhey L, Koehler A, Schneider R, Gragoudas E. Clinical experience and expectation with protons and heavy ions. Int J Radiat Oncol Biol Phys. 3:115-125, 1977. Gragoudas E, Goitein M, Koehler A, Wagner M, Verhey L, Tepper J, Suit H, Schneider R, Johnson K. Proton irradiation of choroidal melanomas. Arch Ophthalmol. 96:1583-1591, 1978. Gragoudas E, Goitein M, Koehler A, Wagner M, Verhey L, Tepper J, Suit H, Schneider R, Johnson K. Proton irradiation of malignant melanoma of the ciliary body. Brit J Ophthalmol. 63:135-139, 1979. Shipley W, Tepper J, Prout G, Verhey L, Mendiondo O, Goitein M, Koehler A, Suit H. Proton radiation as boost therapy for localized prostatic carcinoma. JAMA 241:1912-1915, 1979. Verhey L, Koehler A, McDonald J, Goitein M, Ma I-C, Schneider R, Wagner M. The determination of absorbed dose in a proton beam for purposes of charged particle radiation therapy. Radiat Res. 79:34-54, 1979. Suit HD, Goitein M, Munzenrider JE, Verhey L, Gragoudas E, Koehler AM, Urano M, Shipley WU, Linggood RM, Friedberg C, Wagner M. Clinical experience with proton beam radiation therapy. J Canad Assoc Radiol. 31:35-39, 1980.
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28. 29. 30. 31.

32. 33. 34. 35. 36.

37.

38. 39. 40. 41. 42.

Gragoudas E, Goitein M, Verhey L, Munzenrider J, Suit H, Koehler A. Proton beam irradiation: an alternative to enucleation for intra-ocular melanomas. Ophthalmol. 87:571581, 1980. Urano M, Goitein M, Verhey L, Mendiondo O, Suit H, Koehler A. Relative Biological effectiveness of a high energy modulated proton beam using a spontaneous murine tumor in vivo. Int J Radiat Oncol Biol Phys. 6:1187-1193, 1980. Munzenrider JE, Shipley WU, Verhey LJ. Future prospects of radiation therapy with protons. Sem Oncol. 8:110-124, 1981. Shambroom WD, Gordon BA, Loomis WA, Pipkin FM, Pordes SH, Verhey LJ, Wilson R, Anderson HL, Fine RM, Heisterberg RH, Matis HS, Mo LW, Myrianthopoulos LC, Wright SC, Francis WR, Hicks WR, Kirk TBW, Bharadwaj VK, Booth NE, Kirkbride GI, Quirk TW, Skuja A, Williams WSC. Coherent production of mesons in muon-carbon scattering at 150 and 100 GeV. Phys Rev. 24:775-777, 1981. Verhey LJ, Goitein M, McNulty P, Munzenrider JE, Suit HD. Precise positioning of patients for radiation therapy. Int J Radiat Oncol Biol Phys. 8:289-294, 1982. Suit HD, Goitein M, Munzenrider J, Verhey L, Davis KR, Koehler A, Linggood R, Ojemann RG. Definitive radiation therapy for chordoma and chondrosarcoma of base of skull and cervical spine. J Neurosurg. 56:377-385, 1982. Gragoudas ES, Goitein M, Verhey L, Munzenrider J, Urie M, Suit H, Koehler A. Proton beam irradiation of uveal melanomas: results of 5 ½ year study. Arch Ophthalmol. 100:928-934, 1982. Goitein M, Abrams M, Gentry R, Urie M, Verhey L, Wagner M. Planning treatment with heavy charged particles. Int J Radiat Oncol Biol Phys. 8:2065-2070, 1982. Suit HD, Goitein M, Munzenrider J, Verhey L, Blitzer P, Gragoudas E, Koehler AM, Urie M, Gentry R, Shipley W, Urano M, Duttenhaver J, Wagner M. Evaluation of the clinical applicability of proton beams in definitive fractionated radiation therapy. Int J Radiat Oncol Biol Phys. 8:2199-2205, 1982. Duttenhaver JR, Shipley WU, Perrone T, Verhey LJ, Goitein M, Munzenrider JE, Prout GR, Kerr WS, Parkhurst EC, Suit HD. Protons or megavoltage x-rays as boost therapy for patients irradiated for localized prostatic carcinoma: an early phase I/II comparison. Cancer 51:1599-1604, 1983. Verhey LJ, Sedlacek R. Determination of the radioprotective effects of topical applications of MEA, WR-2721 and N-acetylcysteine on murine skin. Radiat Res. 93:175-183, 1983. Urano M, Verhey LJ, Goitein M, Tepper JE, Suit HD, Mendiondo O, Gragoudas ES, Koehler A. Relative biological effectiveness of modulated proton beams in various murine tissues. Int J Radiat Oncol Biol Phys. 10:509-514, 1984. Gragoudas ES, Goitein M, Seddon J, Verhey L, Munzenrider J, Urie M, Suit HD, Blitzer P, Johnson KN, Koehler A. Preliminary results of proton beam irradiation of macular and paramacular melanomas. Brit J Ophthalmol. 68:479-485, 1984. Gragoudas ES, Seddon J, Goitein M, Verhey L, Munzenrider J, Urie M, Suit HD, Blitzer P, Koehler A. Current results of proton beam irradiation of uveal melanomas. Ophthalmology 92:284-291, 1985. Austin-Seymour M, Munzenrider JE, Goitein M, Gentry R, Gragoudas E, Koehler AM, McNulty P, Osborne E, Ryugo DK, Seddon J, Urie M, Verhey L, Suit HD. Progress in low LET heavy particle therapy: intracranial and paracranial tumors and uveal melanomas. Radiat Res. 104:S219-S226, 1985.

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43. 44. 45. 46. 47. 48. 49. 50. 51. 52.

53.

54.

55.

56. 57.

Seddon JM, Gragoudas ES, Polivogianis L, Hsieh CC, Egan KM, Goitein M, Verhey L, Munzenrider J, Austin-Seymour M, Urie M, Koehler A. Visual outcome after proton beam irradiation of uveal melanoma. Ophthalmol. 93:666-674, 1986. Gragoudas ES, Seddon JM, Egan KM, Polivogianis L, Hsieh CC, Goitein M, Verhey L, Munzenrider J, Austin-Seymour M, Urie M, Koehler A. Prognostic factors for metastasis following proton beam irradiation of uveal melanomas. Ophthalmol. 93:675-680, 1986. Petti PL, Verhey L, Wilson R. A measurement of w for 150 MeV protons in nitrogen and argon. Phys. Med. Biol. 31:1129-1138, 1986. Gragoudas ES, Seddon JM, Egan K, Glynn R, Munzenrider J, Austin-Seymour M, Goitein M, Verhey L, Urie M, Koehler A. Long-term Results of Proton Beam Irradiated Uveal Melanomas. Ophthalmol. 94:349-353, 1987. Seddon JS, Gragoudas ES, Egan KM, Glynn RJ, Munzenrider JE, Austin-Seymour M, Goitein M, Verhey L, Urie M, Koehler A. Uveal Melanomas Near the Optic Disc or Fovea: Visual Results after Proton Beam Irradiation. Ophthalmol. 94: 354-361, 1987. Suit HD, Phil D, Becht J. Leong J, Stracher M. Wood WC, Verhey L, Goitein M. Potential for Improvement in Radiation Therapy. Int. J. Radiation Oncology Biol. Phys. 14:777-786, 1988. Gragoudas ES, Seddon JM, Egan KM, Glynn RJ, Goitein M, Munzenrider J, Verhey L, Urie M, Koehler A. Metastasis from Uveal Melanoma after Proton Beam Irradiation. Ophthalmol. 95: 992-999, 1988. Suit HD, Griffin TW, Castro JR, Verhey LJ. Particle Radiation Therapy Research Plan. Amer. J. Clin. Oncol. 11:330-341, 1988. Suit HD, Verhey L. Precision in Radiotherapy: Precision in megavoltage radiotherapy. British J Radiol. 22:17-24, 1988. Munzenrider JE, Gragoudas E, Seddon J, Sisterson J, McNulty P, Birnbaum S, Johnson K, Austin-Seymour M, Slater J, Goitein M, Verhey L, Urie M, Ruotolo D, Egan K, Osuna F. Conservative treatment of uveal melanoma: probability of eye retention after proton treatment. Int. J. Radiat. Oncol. Biol. Phys. 15:553-558, 1988. Slater JD, Austin-Seymour M, Munzenrider J, Birnbaum S, Carroll R, Klibanski A, Riskind P, Urie M, Verhey L, Goitein M. Endocrine Function Following High Dose Proton Therapy for Tumor of the Upper Clivus, Int. J. Radiat. Oncol. Biol. Phys. 15:607-611, 1988. Suit HD, Sedlacek R, Silver G, Hsieh CC, Epp ER, Ngo FQ, Roberts WK, Verhey L. Therapeutic Gain Factors for Fractionated Radiation Treatment of Spontaneous Murine Tumors Using Fast Neutrons, Photons Plus 021 or 3 ATA, or Photons Plus Misonidazole. Radiat. Research 116:482-502, 1988. Austin-Seymour M, Munzenrider J, Goitein M, Verhey L, Urie M, Gentry R, Birnbaum S, Ruotolo D, McManus P, Skates S, Ojemann R, Rosenberg A, Schiller A, Koehler A, Suit H. Fractionated proton radiation therapy of chordoma and low-grade chondrosarcoma of the base of the skull. J Neurosurg 70:13-17, 1989. Rabin MSZ, Gottschalk B., Koehler A., Sisterson J., Verhey LJ. Compact designs for comprehensive proton beam clinical facilities. Nuclear Instruments and Methods in Physics Research B40/41: 1335-1339, 1989. Habrand JL, Austin-Seymour M, Birnbaum S, Wray S, Carroll R, Munzenrider JE, Verhey LJ, Urie M, Goitein M. Neurovisual Outcome Following Proton Radiation Therapy. Int. J. of Radiat Oncol Biol Phys. 16: 1601-1606, 1989.

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Munzenrider JE, Verhey LJ, Gragoudas ES, Seddon JM, Urie M, Gentry R, Birnbaum S, Ruotolo DM, Crowell C, McManus P, Finn S, Sisterson J, Johnson K, Egan K, Lento D., Bassin P. Conservative Treatment of Uveal Melanoma: Local Recurrence after Proton Beam Therapy. Int. J. Radiat. Oncol. Biol. Phys. 17: 493-498, 1989. Egan KM, Gragoudas ES, Seddon JM, Glynn RJ, Munzenrider JE, Goitein M, Verhey L, Urie M, Koehler A. The Risk of Enucleation after Proton Beam Irradiation of Uveal Melanoma. Ophthalmol. 96: 1377-1383, 1989. Dicello JF, Lyman JT, McDonald JC, Verhey LJ. A portable system for microdosimetric intercomparison by Task Group #20 of the American Association of Physicists in medicine (AAPM). Nuclear Instruments and Methods in Physics Research B45: 724-729, 1990. Austin-Seymour M, Urie M, Munzenrider JE, Goitein M, Verhey LJ, Gentry R, McNulty P, Koehler A, Suit HD. Considerations in Fractionated Proton Radiation Therapy: Clinical potential and results. Radiotherapy and Oncology 17: 29-35, 1990. Suit HD, Goitein M, Munzenrider JE, Verhey LJ, Urie M, Gragoudas ES, Koehler A, Gottschalk B, Sisterson J, Tatsuzaki H, Miralbell R. Increased Efficacy of Radiation Therapy by use of Proton Beam. Strahlenther. Oncol. 166: 40-44 (Nr. 1), 1990. Austin-Seymour M, Munzenrider J, Linggood R, Goitein M, Verhey L, Urie M, Gentry R, Birnbaum S, Ruotolo D, Crowell C, McManus P, Skates S, Koehler A, Suit H. Fractionated Proton Radiation Therapy of Cranial and Intracranial Tumors. Am J of Clinical Oncol. 13(4): 327-330, 1990. Hiraoka T, Kawashima K, Hoshino K, Kawachi K, Kanai T, Ito A, Verhey L, McDonald JC, Ma I-C. Small Scale Proton Dosimetry Intercomparison between Japan and USA. Jpn. Radiol. Phys. 9(3): 135-141, 1989. Dugan T, Shipley W, Young R, Verhey L, Althausen A, Heney N, McManus P, Abraham A. Biopsy after External Beam Radiation Therapy for Adenocarcinoma of the Prostate: Correlation with Original Histologic Grade and Current Prostatic Antigen Levels. Journal of Urology 146: 1313-1316, 1991. Verhey L and Lyman J. Some Considerations Regarding w Values for Heavy ChargedParticle Radiotherapy. Medical Physics 19(1): 151-153, 1992. Schulz RJ, Verhey LJ, Huq MS, Venkataramanan N. Water-Calorimeter Dosimetry for 160 MeV Protons. Phys. Med. Biol. 37(4): 947-3, 1992. Gall KP, Verhey L, Alonso J, Castro J, Collier JM, Chu W, Daftari I, Goitein M, Kubo H, Ludewigt B, Munzenrider J, Petti P, Renner T, Rosenthal S, Smith A, Staples J, Suit H, Thornton A. State of the Art? New proton medical facilities for the Massachusetts General Hospital and the University of California Davis Medical Center. Nuc. Inst. Methods B79: 881-884, 1993. Gall KP, Verhey LJ, Wagner M. Computer-Assisted Positioning of Radiotherapy Patients using Implanted Radiopaque Fiducials. Med. Phys. 20(4): 1153-1159, 1993. Roach M, Pickett B, Rosenthal SA, Verhey L, Phillips TL. Defining Treatment Margins for Six Field Conformal Irradiation of Localized Prostate Cancer. Int. J. Radiat. Oncol. Biol. Phys. 28: 267-275, 1993. Zhou S, Verhey LJ. A robust method of multileaf (MLC) leaf-configuration verification. Phys. Med. Biol. 39: 1929-1947, 1994. Pickett B, Roach M, Horine P, Verhey L, Phillips TL. Optimization of the oblique angles in the treatment of prostate cancer during six-field conformal radiotherapy. Medical Dosimetry 19: 237-254, 1994.

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Yu CX, Yan D, Du MN, Zhou S, Verhey LJ. Optimization of leaf positions when shaping a radiation field with a multileaf collimator. Phys. Med. Biol. 40: 305-308, 1995. Wara W, Bauman G, Gutin P, Ciricillo S, Larson D, McDermott M, Sneed P, Verhey L, Smith V, Petti P, Edwards M: Stereotactic Radiosurgery in Children. Stereotact. Func. Neurosurg. 64(syoo, 1): 118-125, 1995. Shipley WU, Verhey LJ, Munzenrider JE, Suit HD, Urie MM, McManus PL, Young RH, Shipley JW, Zietman AL, Biggs PJ, Heney NM, Goitein M. Advanced Prostate Cancer: The Results of a Randomized Comparative Trial of High Dose Irradiation Boosting with Conformal Protons Compared with Conventional Dose Irradiation Using Photons Alone. Int. J. Radiat. Oncol. Biol. Phys. 32: 3-12, 1995. Pickett B, Roach M, Verhey L, Horine P, Malfatti C, Akazawa C, Dea D, Varad B, Rathbun C, Phillips TL. The Value of Nonuniform Margins for Six-Field Conformal Irradiation of Localized Prostate Cancer. Int. J. Radiat. Oncol. Biol. Phys. 32: 211-218, 1995. Serago CF, Thornton AF, Urie MM, Chapman P, Verhey L, Rosenthal SJ, Gall KP, Niemierko A. Comparison of proton and x-ray conformal dose distributions for radiosurgery applications. Med. Phys. 22(12): 2111-2116, 1995. McDermott MW, Sneed PK, Chang SM, Gutin PH, Wara WM, Verhey LJ, Smith V, Petti PL, Ho M, Park E, Edwards MSB, Prados MD, Larson DA. Results of Radiosurgery for Recurrent Gliomas. in Kondziolka D (ed): Radiosurgery 1995. Basel, Karger, 1996, vol 1, pp 102-112. Baumann GS, Wara WM, Larson DA, Sn