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Case1:04-cv-00968-GIVIS Document 54-24 Filed 05/O2/2005 Page1 0f4
EXHIBIT K

3 Case 1:04-cv—OO968-G|\/IS Document 54-24 Filed 05/O2/2005 Page 2 of 4
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MOLECULAR BIOLOGY OF
THIRD EDITION
Bruce Alberts • Dennis Bray
Iulian Lewis • Martin Raff • Keith Roberts
Iames D. Watson
Garland Publishing, Inc.
New York & London

Case 1 :04-cv—OO968-GIVIS Document 54-24 Filed 05/O2/2005 Page 3 of 4
ll Text Editor: Miranda Robertson g
V Managing Editor: Ruth Adams r
l Illustrator: Nigel Orme ‘
l Molecular Model Drawings: Kate Hesketh-Moore
{ Director of Electronic Publishing: John M-Roblin
Q Computer Specialist: Chuck Bartelt i
j Disk Preparation: Carol Winter
l Copy Editor: Shirley M. Cobert
Production Editor: Douglas Goertzen
ll Production Coordinator: Perry Bessas
ig Indexer: Maija Hinkle
t
Bruce Alberts received his Ph.D. from Harvard University and is
currently President of the National Academy of Sciences and Professor
tl of Biochemistry and Biophysics at the University of California, San
l Francisco. Dennis Bray received his Ph.D. from the Massachusetts
l Institute of Technology and is currently a Medical Research Council
Fellow in the Department of Zoology, University of Cambridge.
l julian Lewis received his D.Phil. from the University of Oxford and is
i currently a Senior Scientist in the Imperial Cancer Research Fund
Developmental Biology Unit, University of Oxford. Martin Raj? received
l his M.D. from McGill University and is currently a Professor in the MRC
Laboratory for Molecular Cell Biology and the Biology Department,
University College London. Keith Roberts received his Ph.D. from the
University of Cambridge and is currently Head of the Department of Cell
Biology, the Iohn Innes Institute, Norwich. James D. Watson received his
Ph.D. from Indiana University and is currently Director of the Cold Spring
Harbor Laboratory. He is the author of Molecular Biology ofthe Gene and,
I zi with Francis Crick and Maurice Wilkins, won the Nobel Prize in Medicine
— l and Physiology in 1962.
© 1983, 1989, 1994 by Bruce Alberts, Dennis Bray, Iulian Lewis,
Martin Raff, Keith Roberts, and Iames D. Watson.
All rights reserved. N 0 part of this book covered by the copyright hereon 4
may be reproduced or used in any form or by any means—graphic, ·
I electronic, or mechanical, including photocopying, recording, taping, or
p information storage and retrieval systems—without pennission of the
l publisher.
Library of Congress Cataloging-in-Publication Data Y
, Molecular biology of the cell / Bruce Alberts . . . [et al.].—3rd ed.
l p. cm. ¤
Includes bibliographical references and index. Fmm °°v°r° 99 Ph·>*¤e9¤h Shows a rat nerve cell ,
i 1sBN 0-8153-1619-4 (hard cover) .—ISBN 0-81534620-8 (pbk.) ;,I;,5;lr£l;r;,€§§;;ssl:i)r$;€l§;(c};lll;)g;1;»`/anrrdrl ggrygriisccent
l. Cytology. 2. M0l8Cula1' biology. I. Alberts, B1'l1C€. processes, Nerve terminals ( green) from other {
Q [DNLM: 1. Cells. 2. Molecular Biology. QH 581.2 M7l8 1994] HBUIOHS (HDI visible). which have m¤d€ SY¤¤PS€S 0¤ if
99991-2-M641994 t2:.i$.‘;;;:::2€,i;l€,S.x:;t*:,tSiftttaaztzbsstm,,
if Dedication page: Gavin Borden, late president E
9¤9¤b*9tv¤fC¤¤gI999 99-49999 3l£?‘f§%‘5‘SStillsEL2€’r$r”§E?.l€rCFFr£{E,S.$‘&£§.h‘S
CIP MBoC author Bruce Alberts and famous mountaineer I
; Published by Garland Publishing, Inc. guide Mugs Stump (l940—1992). _*
717 Fifth Avemm New York NY 1.0022 Back cover: The authors, in alphabetical order,
l crossing Abbey Road in London on their way to lunch.
l Printed in the United States of America Much of this third edition was written in a house just g;
l around the corner. (Photograph by Richard Olivier.) rf
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in ‘n ii n nigh) tilt; ~>i ine ttliems 4-znhnsplniieetoe/02/2005 Pa e 4 or 4
l in llio§€A6h gate . EU 5 Reaction in which a phosphage group becomes CO_
pathogen (adjective pathogenic) valently coupled to another molecule.
An or anism or other a ent that causes diseases. photon n
. 8 3 . .
A PCR (polymerase chain reaction) ggrggrgtiiry particle of light and other electromagnetic {
· Technique for amplifying specific regions of DNA by ` j
multiple cycles of DNA polymerization, each followed by photosynthesis ;
a brief heat treatment to separate complementary Process by which plants and some bacteria use the en-
‘ strands. ergy of sunlight to drive the synthesis of organic mol- D
peptide bond ecules from carbon dioxide and water.
Chemical bond between the carbonyl group of one phylogeny
amino acid and the amino group of a second amino Evolutionary history of an organism or group of organ- ‘ j
acid—a special form of amide linkage. (See Figure 2—7.) isms, often presented ln chart form as a h lo enet‘
P Y g IC
. tree.
peptide map
Characteristic two-dimensional pattern (on paper or gel) pinocytosis
formed by the separation of the mixture of peptides pro- Type of endocytosis in which soluble materials are taken
duced by the partial digestion of a protein. " up from the environment and incorporated into vesicles
. for digestion. Literally, “cell drinking." ff
PBIOXISOIIIC
Small membrane-bounded organelle that uses molecu- plasma membrane
lar oxygen to oxidize organic molecules. Contains some Membrane that surrounds a living cell. Y?
enzymgs Ellriigngoduce and others that degrade hydrogen plasmid
pemxl E 2 2 ' Small circular DNA molecule that replicates inde S
pen- eg
pH dently of the genome. Used extensively as a vector for ei.
Common measure of the acidity of a solution: “p" refers DNA cloning. Q
to power of 10, "H" to hydrogen. Defined as the negative lasmodcsma ( luml lasmodesmata)
logarithm of the hydrogen ion concentration in moles p Commumcgtm Cl;H_C€H lmction in mms in h. h .
per liter (M). Thus pH 3 (10‘3 M H*) is acidic and pH 9 g . I P W lc a >
(104, M H,) is alkaline channel of cytoplasm lined by plasma membrane con- j
` nects two adjacent cells through a small pore in their cell i
phage—see bacteriophage walls. .
lastid
Ph“g°°Y‘° P cr 1 · iii lei ie eaab ei ei
General term for a professional phagocytic cell-that is, y Op asmlc nignnn .6 li P D S' Ou 8 . y 3 Ou. B `
a cell such as a macrophage or neutrophil that is special— Qgggéaréilgggfaiiglgig{512;/:§j?NA and IS Often plg` .
ized to take up particles and microorganisms by phago- ‘ ` i
cytosis. platelet .
. Cell fragment, lacking a nucleus, that breaks off from a
phagocytosis . . . . megakaryocyte in the bone marrow and is found in large `
rocess by which particulate material is endocytosed . . . . g
rt ,, . . . numbers in the bloodstream. lt helps initiate blood clot- p
( eaten ) by a cell. Prominent in carnivorous cells, such tm when blood Vessels are mured .
as Amoeba proteus, and in vertebrate macrophages and g 1 '
neutrophils. (From Greek phagein, to eat.) plus end
hem) e The end of a microtubule or actin filament at which ad-
P tYP . dition of monomers occurs most readily; the "fast-grow- .
The Obsewable character Of a cell Or an OrgamSm' ing" end ofa microtubule or actin filament. The plus end .
phosphatase—see phosphoprotein phosphatase of an actin hlament is also known as the barbed end. (See ¢
Panel 16-1, pp. 824-825.)
phosphatidylinositol . . —
. . . . . _ point mutation .
AH ‘“°S“°l l’h°Sl’h°“l°‘d· (See F‘g““" 15 29* Change of e single nucleotide in one, especially in e re- .
phosphodiester bond} gion of DNA coding for protein. ;
A covalent chemical bond formed when two hydroxyl Olar bond
gnnini nn linlinil in inn linlnnn in lin innn nlnnnnnn " ceveiem eee in Witten the electrons attracted more
group, such as adjacent nucleotides in RNA or DNA. (See 1 I _ f h . Olarized ;
Fi rc 2_10.) strongy to one o t Ae two atoms, creating a p L
gu distribution of electric charge. I
phosph0inositide—see inositol phospholipid polar molecule *
· . Molecule in which there is a polarized distribuii0Q of
ph0?hh0llp¥d fl. .d 1 1 d t { positive and negative charges due to an uneven diSif1bu‘
b- B major category O 1p1 H10 ecu €s use O cons ruct [lOl'1 of €l€CIfO1'1S. POl3l” I]lOl€CLll€$ AIC to be Soluble
iological membranes. Generally composed of two fatty in Water it
acids linked through glycerol phosphate to one of a va- ‘
riety of polar groups. A ` polymer
phosphoprotcin phosphatase L€lfg€ molecule made by forming a series of covalent
Enzyme that iemeeeeeeheephete group eemepieere ;’€‘;;1f’lh‘*‘l"‘km“*t‘l’*°‘d€"““"]°“‘m"i“““"S im pj
byhydrolysis. `
i polymerase chain reaction—sec PCR _
G—18 Glossary i g