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Curriculum Vita Valentino J. Stella
Address: Home: 1135 West Campus road, Lawrence, Kansas 66044 Work: The University of Kansas, Department of Pharmaceutical Chemistry 2095 Constant Avenue, Lawrence, KS 66047 Telephone: (785) 843-8807 (residence); (785) 864-3755 (work); (785) 864-5736 (FAX) E-mail:
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1990-present: University Distinguished Professor of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas. Teaching Experience: On the undergraduate level, Professor Stella has taught courses in physical pharmacy, solid formulations, laboratories, drug stability and equilibria, biopharmaceutics and pharmacokinetics, senior dispensing and undergraduate research. At the graduate level, he has taught courses in drug stability, pharmaceutical equilibria, advanced biopharmaceutics and pharmacokinetics, as well as directed graduate research, journal clubs and seminar discussions. Editorial Experience: Professor Stella is on the editorial board of Pharmaceutical Research, the official journal of the American Association of Pharmaceutical Scientists and Journal of Pharmaceutical Sciences, the official journal of the American Pharmaceutical Association. He currently reviews papers for the following journals on a regular basis: Journal of Pharmaceutical Sciences International Journal of Pharmaceutics Pharmaceutical Research Analytical Chemistry Journal of Medicinal Chemistry Journal of Pharmacokinetics and Biopharmaceutics Journal of Controlled Release Journal of the American Chemical Society Bioorganic and Medicinal Chemistry Letters Journal of Carbohydrate Chemistry He currently reviews book proposals for: CRC press J. Wiley & Sons. Professional Organization Memberships American Association of the Advancement of Science, fellow, member of the nomination committee, 1985-1988. American Chemical Society, member Rho Chi American Association of Pharmaceutical Scientists, member and Fellow American Association of Colleges of Pharmacy, member Controlled Release Society, member
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Honors and Awards: Undergraduate Top in class in physics, pharmaceutics and aggregate points in first year pharmacy at VCP (1965). Top in class in physical pharmacy and pharmaceutics in third year pharmacy at VCP (1967).
Graduate - Kansas University Guesthouse Fellow (1970-71) University Level - Teaching - H.O.P.E. Award (University of Kansas), 1989 graduating class. Graduate Teacher award for Pharmaceutical Chemistry, Center for Teaching Excellence (University of Kansas), 2001. University Level - Scholarship - Dolph Simons Award (University of Kansas) for Biomedical Research, 1990. State and Local - Director of the KTEC sponsored Center for Drug Delivery Research 1989-1999 Finalist for the 1996 Technology of the Year Award - Silicone Prairie Technology - Biosciences division. Finalist for the 2000 Technology of the Year Award - Biosciences division Silicone Prairie Technology - Biosciences divison. National/International - Victorian Professor, Victorian College of Pharmacy, 1980 - present Sato Memorial International award for biomedical research, Sendai, Japan, March, 1995 Nominated for the "Australia Prize" for 1996 (not awarded). Honorary Ph.D. Kuopio University, awarded, June 8, 1996 Honorary Doctor of Laws, Monash University (Victorian College of Pharmacy), awarded, May 13, 1997 Outstanding Poster in Pharmaceutical Sciences, 1997 Australasian Pharmaceutical Science Association Annual meeting, Sydney, Australia, Nov. 1997 Research Achievement in Pharmaceutics award, AAPS, awarded at the 12th annual meeting in Boston, November 2-6, 1997. Aya and Takeru Higuchi Memorial Lecturer - Academy of Pharmaceutical Science and Technology, Japan - awarded in San Francisco - April 2000. Honorary Fellow of the Cyclodextrin Society of Japan - awarded in Atsugi City, September 2000. Recognized for outstanding teaching at the University of Kansas at 2001 annual meeting of the American Association of Colleges of Pharmacy Gugliemo M Marconi Science Award, UNICO, Phoenix, May 13, 2004 Professional Organizations Fellow of AAAS (1982)
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Fellow of the Academy of Pharmaceutical Sciences (1984) Fellow of the American Association of Pharmaceutical Scientists (1987) Fellow of the Cyclodextrin Society of Japan (2000) Governmental Organizations - NIH Pharmacology Study Section Reviewer (1983-89) Private Organizations - Lederle Award (1972, 1975) Research Interests: General research interests might be defined as the application of physical organic chemistry to solving pharmaceutical problems (prodrugs, drug stability, biopharmaceutics and pharmacokinetics, especially as they relate to prodrugs, dissolution and other phase transport phenomena, etc. Specifically: 1. Prodrugs . 2. Novel drug delivery systems. 3. Preformulation studies on parenteral cytotoxic and AntiAIDs drugs. 4. Hyaluronic and alginic acid esters as drug delivery matrices. 5. Development and assessment of novel, modified cyclodextrins. 6. Novel prodrugs of imides, amides and ureas. 7. Novel prodrugs of carbon acids Postgraduate Students Supervised: 1. D. Wang, "The Properties of Ditheophylline Succinamide - A Prolonged Release Prodrug Form of Theophylline". M.S. Thesis to the University of Kansas, 1975. 2. C.K. Chu, "Effects of Chronic and Short-term Dietary Exposure to Polychlorinated Biphenyls on the Pharmacokinetics of Pentobarbital in Rats". Ph.D. Dissertation to the University of Kansas, 1979. 3. K.G. Mooney, "Dissolution Kinetics of Organic Acids". Ph.D. Dissertation to the University of Kansas, 1979. 4. J.D. Pipkin, "Tautomerism of Phenindione in Nonaqueous Solvent Systems". Ph.D. Dissertation to the University of Kansas, 1980. 5. S.A. Varia, "Water Soluble Prodrugs of 5,5-Diphenylhydantoin". Ph.D. Dissertation to the University of Kansas, 1981. 6. D.B. Williams, "Sulfation of Phenolic Drugs". Ph.D. Dissertation to the University of Kansas, 1983. 7. V.H. Naringrekar, "Enamines as Potential Prodrugs of Primary Amines". Ph.D. Dissertation to the University of Kansas, 1984. 8. S. Jivani, "Mechanism of Decarboxylation of p-Aminosalicylic Acid". M.S. Thesis to the University of Kansas, 1985. 9. W.N.A. Charman, "Analytical Techniques for the Assessment of the Bioavailability of Agents Affecting Pigmentation of the Skin." Ph.D. Dissertation to the University of Kansas, 1985. 10. S. Martodihardjo, "Low-Melting Phenytoin Prodrugs: In Vitro and In Vivo Correlations." Ph.D. Dissertation to the University of Kansas, 1987.
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11. M. Z. Southard, " Transport Mechanisms of Sparingly Soluble Acid Dissolution in Aqueous Solution of Variable pH." Ph.D. Dissertation to the University of Kansas, 1988. Co-advised with K. Himmelstein and H. Rosson. 12. J. Sisco, "The Physicochemical, Analytical and Pharmacokinetic Properties of the Antineoplastic Agent, ICRF-187." Ph.D. Dissertation to the University of Kansas, 1989. 13. R. A. Myers, "Systemic Bioavailability and Lymphatic Transport of Penclomedine and Other Polychlorinated Compounds." Ph.D. Dissertation to the University of Kansas, 1990. 14. R. Rajewski, "Development and Evaluation of the Usefulness and Parenteral Safety of Modified Cyclodextrins." Ph.D. Dissertation to the University of Kansas, 1990. 15. A. S. Kearney, "Evaluation of the Pharmaceutical Potential of Phosphate Mono-ester Prodrugs." Ph.D. Dissertation to the University of Kansas, 1990. 16. L.S.J. Dias, "Dissolution of Weak Acids from the Rotating Disc Apparatus: Modifications by Buffers and Surface Area Availability." Ph.D. Dissertation to the University of Kansas, 1991. 17. N. Pochopin-Barber, "Amino Acid Amides as Water-Soluble Prodrugs of Primary Aromatic Amines." Ph.D. Dissertation to the University of Kansas, 1991. 18. L. Rajewski, "Mechanistic Study of Hydrocortisone Release from Devices of Hydrocortisone Esters of Hyaluronic Acid." Ph.D. Dissertation to the University of Kansas, 1992. 19. R. Oliyai, "The Kinetics and Mechanism of N,O-Acyl Migration in Cyclic and Linear Peptides." Ph.D. Dissertation to the University of Kansas, 1993. 20. H. Y. Lee, "The Effect of Modified -Cyclodextrin, SBE4--CD, on the Pharmacokinetics of Two Steroids." M.S. Thesis to the University of Kansas, 1994. 21. S. Neervannan, "Dissolution Mechanisms for Sparingly Soluble Compounds Under Laminar Hydrodynamic Conditions." Ph.D. Dissertation to the University of Kansas, 1994. 22. A. S. Antipas, "Effect of Conformation on the Rate of Deamidation of Vancomycin in Aqueous Solutions." Ph.D. Dissertation to the University of Kansas, 1994. 23. L. Simon,"Mechanisms of Diffusion and Release of Proteins from Partially Esterified Hyaluronic Acid Matrices." Ph.D. Dissertation to the University of Kansas, 1996. 24. D. Ma, "Evaluation of Sulfobutyl Ether Beta-Cyclodextrin as a Solubilizing/Stabilizing and Freeze-Drying Excipient." Ph.D. Dissertation to the University of Kansas, 1998. 25. J. Krise, "A Novel Prodrug Approach for Tertiary Amines: Synthesis and Evaluation of N-Phosphosphonooxymethyl Derivatives." Ph.D. Dissertation to the University of Kansas, 1998. 26. V. Zia, "Thermodynamics and Mechanism of Inclusion Complexation: Specific Comparison of Sulfoakyl Ether -Cyclodextrins to Hydroxypropyl -Cyclodextrin." Ph.D. Dissertation to the University of Kansas, 1998. 27. Venkataramana Rao, "Modified Release Oral Dosage Forms of Poorly Water Soluble Drugs Including the Use of (SBE)7M--CD", Ph.D. Dissertation to the University of Kansas, 2000.
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28. Erika Zannou, "A Mechanistic Study of Drug Release from Cyclodextrin-Based Controlled Porosity Osmotic Pump Tablets", Ph.D. Dissertation to the University of Kansas, 2000. 29. Brad Hanson, "Evaluation of a Phosphoryloxymethyl (POM) Prodrug of Camptothecin: Preformulation, Formulation and Pharmacokinetic Studies," Ph.D. Dissertation to the University of Kansas, 2002. 30. Victor Guarino, " Sulfenamide Prodrugs: A Novel Prodrug Appraoch for Amides, Imides and Other NH-Acidic Compounds," Ph.D. Dissertation to the University of Kansas, 2004. Post-Doctoral, Special Students and Visiting Scientists Supervised: 1. H. Okada, Tokyo University of Pharmacy and Life Science, Tokyo, Japan 2. N. Yata, Professor, Hiroshima University, Hiroshima, Japan 3. Y. Yamaoka, Kobe Kakuan University, Kobe, Japan 4. K. Yamaoka, Kyoto University, Kyoto, Japan 5. J.C. Lee, Cellegy, CA 6. P. Kennedy, British Columbia 7. M. Paborji, Theravance, CA 8. K. Umprayn, Chulalongkorn University, Bangkok, Thailand 9. R. Prankerd, Victorian College of Pharmacy, Melbourne, Australia. 10. F. Alvarez, BMS, New Brunswick, NJ 11. K. Terada, Toho University, Tokyo, Japan 12. W. Richter, Hoffman La Roche, Basel, Switzerland 13. J. Hunt, Alza Corp., Palo Alto, CA 14. A. Benedetti, Vicenza, Italy 15. L. Benedetti, Medtronics, Italy 16. K. O' Driscol, Trinity College, Dublin, Ireland 17. R. Killion, Syntex Research, Palo Alto, CA 18. F. Sendo, Kumamoto Research Hospital, Kumamoto, Japan 19. L. Alani, Pfizer Research, Ann Arbor, MI 20. R. Gollopudi, Lyphomed, Chicago, Illinois. 21. O. Kunze, Berlin, Germany 22. A. Mathew, Mobay Corp., Kansas City, Ks 23. J. Fassberg-Berry, Schering-Plough, NJ 24. H. Jahansouz, MSD, West Point, PA. 25. D. Muller, Potchefstroom University, South Africa. 26. Y. Tsunenari, Taisho Pharmaceutical, Tokyo, Japan. 27. K. Aikawa, Taisho Pharmaceutical, Tokyo, Japan. 28. J. Zadeii. Berlex, PA 29. E. Phillips, Dura, San Diego, CA 30. D. Bindra, BMS, New Brunswick, NJ. 31. D. Scott, HMR, Kansas City, Missouri. 32. D. Papini, Glaxo Inc., Verona, Italy. 33. M. Okomura, Sumitomo Pharmaceuticals, Osaka, Japan. 34. T. Sakaeda (nee Kakutani), Kobe University, Kobe, Japan.
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35. G. Marcolongo, Life Group, Padua, Italy. 36. K. Kyyronen, University of Kuopio, Finland. 37. R. Bhaskar, position unknown. 38. S. Hejri, position unknown. 39. L. Hume, Schering Plough., Kenelworth, NJ. 40. V. Andrieu, Synth Labo, Paris, France. 41. K. Bergh, Potchefstroom University, South Africa. 42. B. Gorecka, CA 43. R. Tait, Faulding, Australia. 44. M. Safadi, Taro Pharmaceuticals, Israel. 45. J. Kagel, Parke Davis, Ann Arbor, MI. 46. R. Mansfield, CA. 47. L. Ruiz-Cardona, Puerto Rico. 48. T. Nakamura, Taisho Pharmaceutical, Tokyo, Japan. 49. J. Jona, BMS, New Brunswick, NJ. 50. T. Jarvinen, University of Kupio, Finland. 51. K. Jarvinen, University of Kupio, Finland. 52. N. Umeki, Taisho Pharmaceutical, Tokyo, Japan. 53. Y. Sanzgiri, Abbott Laboratory, North Chicago, IL 54. K. H. Caplinzki, Germany 55. K. Okimoto, Fujisawa Pharmaceutical Company, Osaka, Japan 56. M. Cruañes, Merck, Westpoint, PA. 57. T. Nakajima, Tasiho Pharmaceutical, Tokyo, Japan. 58. H. Alkaysi, Maryland, USA 59. S. Siam, Boehringer-Ingelheim, CN, USA 60. E. Luna, Merck. Westpoint, PA. 61. E. Bornancini, GlaxoSmithKline, PA. 62. S. Narisawa, Tanabe Pharmaceuticals. Osaka, Japan. 63. D. Bempong, USP, Washington, DC. 64. N. Medlicott, Otago University, Dunedin, NZ. 65. S. Shiraishi, Wakunaga Pharmaceutical Co. Ltd., Hiroshima, Japan. 66. H. Uetake, Taisho Pharmaceutical, Tokyo, Japan. 67. K. Egodage, Monstanto, St. Louis, IL. 68. S. Wu, Esei, RTP, North Carolina. 69. P. Jarho, Kuopio University, Kuopio, Finland. 70. O. Kondo, Taisho Pharmaceutical, Tokyo, Japan. 71. S. Chinnaswamy, Van Ardek Institute, Grand rapids, MI 72. S. Ando, Taisho Pharmaceutical, Tokyo, Japan. 73. M. Jumaa, 3M, Minneapolis, MN. 74. L. Chimilio, The University of Kansas, KS 75. S. Tongiani, University of Urbino, Urbino, Italy 76. V. Karunarantne, University of Peradeniya, Sri Lanka 77. M. Miyajima, Sankyo Co. Ltd, Tokyo, Japan. 78. T. Ozeki. Tokyo College of Pharmaceutical Sciences, Tokyo, Japan.
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Publications: Research Papers 1. 2. Kinetics of Synthesis of d4-Succinic Anhydride from Succinic Anhydride and d1Acetic Acid. V. Stella, J. Pharm. Sci., 62, 634-637 (1973). Kinetics of the Acid-Catalyzed Closure of Hydantoic Acids. Effect of 2-Aryl and 2-Alkyl Substituents. V. Stella and T. Higuchi, J. Org. Chem., 38, 1527-1534 (1973). Esters of Hydantoic Acids as Prodrugs of Hydantoins. V. Stella and T. Higuchi, J. Pharm. Sci., 62, 962-967 (1973). Hydrolytic Behavior of N-Acyl Phthalimides. V. Stella and T. Higuchi, J. Pharm. Sci., 62, 968-970 (1973). The Non-classical Phase Transfer Behavior of Phenylbutazone. Valentino J. Stella, J. Pharm. Sci., 64, 706-708 (1975). The Chemistry of a Novel 5,5-Diphenylhydantoin Pro-drug. V. Stella, T. Higuchi, A. Hussain and J. Truelove, Chapter 3, Book #14 of the American Chemical Society Symposium Series (Pro-Drugs Novel Drug Delivery System, T. Higuchi and V. Stella, eds.). (1975). The Metabolic Disposition of a Novel 5,5-Diphenylhydantoin Pro-drug. A.J. Glazko, W.A. Dill, R.H. Wheelock, R.M. Young, A. Nemanich, L. Croskey, V. Stella and T. Higuchi, Chapter 4, Book #14 of the American Chemical Society Symposium Series (Pro-Drugs Novel Drug Delivery System, T. Higuchi and V. Stella, eds.). (1975). Solvolytic Reactions of Cyclic Anhydrides in Anhydrous Acetic Acid. M.J. Haddadin, T. Higuchi and V. Stella, J. Pharm. Sci., 64, 1759 (1975). Acylation of Phenol by Cyclic and Acylic Anhydrides in Anhydrous Acetic Acid. M.J. Haddadin, T. Higuchi and V. Stella, J. Pharm. Sci., 64, 1766 (1975). Photolytic Degradation of -[(Dibutylamino)methyl]-6,8-dichloro-2-(3',4'dichlorophenyl)-4-Quinoline Methanol: An Experimental Anti-Malarial. H. Okada, V. Stella, J. Haslam and N.Yata, J. Pharm. Sci., 64, 1665-1667 (1975). Phenylbutazone Ionization Kinetics. V.J. Stella and J.D. Pipkin, J. Pharm. Sci., 65, 1161-1165 (1976).
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Effects of Long-Term Exposure to Environmental Levels of Polychlorinated Biphenyls on Pharmacokinetics of Pentobarbital in Rats. C.K. Chu, V.J. Stella, J.V. Bruckner and W.D. Jiang, J. Pharm. Sci., 66, 238-241 (1977). A Preliminary Pharmacokinetic Study of Dianhydrogalactitol (NSC-132313) Disposition in the Dog. T. Kimura, L.A. Sternson, V.J. Stella and T. Higuchi, J. Nat. Cancer Inst., 58, 1311-1314 (1977). The Influence of Ingestion of Environmentally Encountered Levels of a Commercial Polychlorinated Biphenyl Mixture (Aroclor 1254) on Drug Metabolism in the Rat. J.V. Bruckner, W.D. Jiang, J.M. Brown, L. Putcha, C.K. Chuand V.J. Stella, J. Pharmacol. Exp. Therap., 202, 22-31 (1977). Use of Trimethylanilinium Hydroxide-Tetramethylammonium Hydroxide as OnColumn Methylating Agent for GLC Analysis of Phenytoin. V.J. Stella, J. Pharm. Sci., 66, 1510-1511 (1977). Secondary Isotope Effects in Intramolecular Catalysis. Mono-p-bromophenyl Succinate Hydrolysis. R.D. Gandour, V.J. Stella, M. Coyne and R.L. Schowen and E.A. Icaza, J. Org. Chem., 43, 1705-1708 (1978). Thiamine Whole Blood Pharmacokinetics in Rat Using Both a Specific 35SThiamine Liquid Scintillation Assay and the Thiochrome Fluorescence Assay. J.D. Pipkin and V.J. Stella, J. Pharm. Sci., 67, 818-821 (1978). Enhancement of the Bioavailability of a Hydrophobic Amine Antimalarial by Formulation with Oleic Acid in a Soft Gelatin Capsule. V. Stella, J. Haslam, N. Yata, H. Okada, S. Lindenbaum and T. Higuchi, J. Pharm. Sci., 67, 1375-1377 (1978). Radiochemical Plasma Salicylamide Assay Using Ring-Labeled Tritiated Salicylamide. V.J. Stella, S.A. Varia and M. Riedy, J. Pharm. Sci., 68, 648-650 (1979). Hydrolysis and Dissolution Behavior of a Prolonged-Release Prodrug of Theophylline: 7,7'-Succinylditheophylline. H.K. Lee, H. Lambert, V.J. Stella, D. Wang and T. Higuchi, J. Pharm. Sci., 68, 288-296 (1979). Ionization Kinetics of the Carbon Acid, Phenindione, V.J. Stella and R. Gish, J. Pharm. Sci., 68, 1042-1047 (1979). Kinetics and Mechanism of Ionization of the Carbon Acids 4'-Substituted 2Phenyl-1,3-Indandiones. V.J. Stella and R. Gish, J. Pharm. Sci., 68, 1047-1049 (1979).
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Proton Inventory of Phthalic Anhydride Hydrolysis. Comments on the Analysis of Proton Inventory Data, R.D. Gandour, M. Coyne, V.J. Stella and R.L. Schowen, J. Org. Chem., 45, 1733-1737 (1980). Effects of Short-Term Dietary Exposure to Polychlorinated Biphenyls on Pharmacokinetics of Intravenous Pentobarbital in Rats. C.K. Chu and V.J. Stella, J. Pharm Sci., 69, 1274-1278 (1980). Effect of Short-Term Exposure to Polychlorinated Biphenyls on First-Pass Metabolism of Pentobarbital in Rats. V.J. Stella and C.K. Chu, J. Pharm. Sci., 69, 1279-1282 (1980). Dissolution Kinetics of Carboxylic Acids I: Effect of pH under Unbuffered Conditions. K.G. Mooney, M. Mintun, K.J. Himmelstein and V.J. Stella, J. Pharm. Sci., 70, 13-22 (1981). Dissolution Kinetics of Carboxylic Acid II: Effect of Buffers. K.G. Mooney, M. Mintun, K.J. Himmelstein and V.J. Stella, J. Pharm. Sci., 70, 22-32 (1981). Prodrugs and Site-Specific Drug Delivery. Valentino J. Stella and K.J. Himmelstein, J. Med. Chem., 23, 1275-1282 (1980). An Added Complication in the Estimation of Apparent Hepatic Blood Flow In Vivo by Pharmacokinetic Parameters. V.J. Stella, K. Yamaoka and R.H. Levy, Drug Met. Disp., 9, 172-173 (1981). Dissolution Kinetics of Phenylbutazone. K.G. Mooney, M. Rodriguez-Gaxiola, M. Mintun, K.J. Himmelstein and V.J. Stella, J. Pharm. Sci., 70, 1358-1365 (1981). Pharmacokinetics of 2-Butanol and Its Metabolites in the Rat. F.K. Dietz, M. Rodriguez-Gaxiola, G.J. Traiger, V.J. Stella and K.J. Himmelstein, J. Pharmaco. Biopharm., 9, 553-576 (1981). Thiamine Whole Blood and Urinary-Pharmacokinetics in Rats: Urethan-Induced Dose-Dependent Pharmacokinetics. J.D. Pipkin and V.J. Stella, J. Pharm. Sci., 71, 169-172 (1982). Prodrugs as Drug Delivery Systems XXI. Preparation, Physicochemical Properties and Bioavailability of a Novel Water-Soluble Prodrug Type for Carbamazepine, H. Bundgaard, M. Johansen, V.J. Stella and M. Cortese, Int. J. Pharm., 10, 181-192 (1982). Tautomerism of Phenindione, 2-Phenyl-1,3-Indanedione, in Dipolar Aprotic/Hydrocarbon Solvent Mixtures. J.D. Pipkin and V.J. Stella, J. Amer. Chem. Soc., 104, 6672-6680 (1982).
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Low-Melting Phenytoin Prodrugs as Alternative Oral Delivery Modes for Phenytoin; A Model for Other High-Melting Sparingly Water Soluble Drugs. Y. Yamaoka, R.D. Roberts and V. J. Stella, J. Pharm. Sci., 72, 400-405 (1983). Evaluation of the Prodrug Potential of Sulfate Esters of Acetaminophen and 3Hydroxymethyl-Phenytoin. D.B. Williams, S.A. Varia, V.J. Stella and I.H. Pitman, Int. J. Pharm., 14, 113-120 (1983). Phenindione Solubility in Mixed Organic Solvents: Analysis of the Role of Specific Hydrogen and Non-Hydrogen Bonding Interactions. J.D. Pipkin and V.J. Stella, Int. J. Pharm., 14, 263-77 (1983). Phenytoin Prodrugs III; Water Soluble Prodrugs for Oral and/or Parenteral Use. S.A. Varia, S. Schuller, K.B. Sloan and V.J. Stella, J. Pharm. Sci., 73, 1068-73 (1984). Phenytoin Prodrugs IV; Hydrolysis of Various 3-(Hydroxymethyl) Phenytoin Esters. S.A. Varia, S. Schuller and V.J. Stella, J. Pharm. Sci., 73, 1074-80 (1984). Phenytoin Prodrugs V; In Vivo Evaluation of Some Water Soluble Phenytoin Prodrugs in Dogs. S.A. Varia and V.J. Stella, J. Pharm. Sci., 73, 1080-87 (1984). Phenytoin Prodrugs VI; In Vivo Evaluation of a Phosphate Ester Prodrug of Phenytoin After Parenteral Administration to Rats. S.A. Varia and V.J. Stella, J. Pharm. Sci., 73, 1087-90 (1984). Dissolution and Ionization of Warfarin. V.J. Stella, K.G. Mooney and J.D. Pipkin, J. Pharm. Sci., 73, 946-948 (1984). A Colorimetric Assay of Pancreatic Lipase: Rapid Detection of Lipase and Colipase Separated by Gel Filtration. J.B. Roberts, V.J. Stella and C.J. Decedue, Lipids, 20, 42-45 (1985). Lymphatic Appearance of DDT in Thoracic or Mesenteric Lymph Duct Cannulated Rats. T. Noguchi, W.N.A. Charman and V.J. Stella, Int. J. Pharmac., 24, 185-192 (1985). Effect of Drug Lipophilicity and Lipid Vehicles on the Lymphatic Absorption of Various Testosterone Esters. T. Noguchi, W.N.A. Charman and V.J. Stella, Int. J. Pharmac., 24, 173-184 (1985). Dissolution of Carboxylic Acids III: The Effect of Polyionizable Buffers. J.G. Aunens, M.Z. Southard, R.A. Myers, K.J. Himmelstein and V.J. Stella, J. Pharm. Sci., 74, 1305-1316 (1985).
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Mechanism of Decarboxylation of p-Aminosalicylic Acid, S. Jivani and V.J. Stella, J. Pharm. Sci., 74, 1274-1282 (1985). An Experimental System Designed to Study the In Situ Intestinal Lymphatic Transport of Lipophilic Drugs in Anesthetized Rats. W.N.A. Charman, T. Noguchi, V.J. Stella, Int. J. Pharmac., 33, 155-164 (1986). Effects of Lipid Class and Lipid Vehicle Volume on the Intestinal Lymphatic Transport of DDT. W.N.A. Charman and V.J. Stella, Int. J. Pharm., 33, 165-172 (1986). Testing Potential Dosage Form Strategies for Intestinal Lymphatic Drug Transport: Studies in the Rat. W.N.A. Charman, T. Noguchi, and V.J. Stella, Int. J. Pharm., 33, 173-179 (1986). Estimating the Maximal Potential for Intestinal Lymphatic Transport of Lipophilic Drug Molecules. W.N.A. Charman and V.J. Stella, Int. J. Pharm., 34, 175-178 (1986). Chemical and Physical Bases Determining the Instability and Incompatibility of Formulated Injectable Drugs. Valentino J. Stella, J. Parent. Sci. Tech., 40, 142163 (1986) Mechanism Investigation of the Degradation of Sulfamic Acid 1,7-Heptanediyl Ester, an Experimental Cytotoxic Agent, in Water and 18Oxygen-Enriched Water. M. Paborji, W. Waugh and V. J. Stella, J. Pharm. Sci., 76, 161-165 (1987). Development of Reversed Phase HPLC Assays for Cyclodisone and Clomesone. K. Umprayn, P.E. Kennedy, J. C. Lee, W. Waugh, C.M. Riley and V.J. Stella, J. Pharm. Biomed. Anal., 5, 625-633 (1987). Stability Indicating Assay for Fetindomide (NSC-373965), a Potential Prodrug of Mitindomide (NSC-284356) Employing High Performance Liquid Chromatography. K. Umprayn, V.J. Stella and C.M. Riley, J. Pharm. Biomed. Anal., 5, 675-685 (1987). An Analytical Method to Determine Small Quantities of Phenytoin in the Presence of Excess Amounts of One of its Prodrugs, the Monomethane Sulphonate Salt of 3-(N,N-dimethylglycyloxymethyl)-5,5-diphenylhydantoin. D. G. Muller and V. J. Stella, J. Pharm. Biomed. Anal., 5, 415-421 (1987). A Novel Use of Intralipid® for the Parenteral Delivery of Perilla Ketone (NSC348407), an investigational Cytotoxic Drug with a High Affinity for Plastic. M. Paborji, C. M. Riley and V. J. Stella, Int. J. Pharmac., 42, 243-249 (1988)
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Preliminary Development and Evaluation of a Parenteral Emulsion Formulation of Penclomidine (NCS-338720, 3,5-dichloro-2,4-dimethoxy- 6 trichloromethylpyridine), a Novel Practically Water Soluble Cytotoxic Agent. R. J. Prankerd, V. J. Stella and S. G. Frank, J. Parenteral Sci. Tech., 42, 76-81 (1988). Equilibria and Kinetics of Ebifuramin (NSC-201047), an Azomethine Containing Structure Exhibiting a Reversible Degradation Step in Acidic Solutions. R. J. Prankerd and V. J. Stella, Int. J. Pharmac., 52, 71-78 (1989). Development of Parenteral Formulations of Experimental Cytotoxic Agents 1; Rhizoxin (NSC-332598). W. N. Waugh, K. Umprayn and V. J. Stella, Int. J. Pharmac., 43, 191-199 (1988). Preformulation Solubility and Kinetic Studies of 2',3'-Dideoxypurine Nucleosides: Potential anti-AIDS agents. B. D. Anderson, M. B. Wygant, T-X. Xiang, W. A. Waugh, and V. J. Stella, Int. J. Pharmac., 45, 27-37 (1988). The Role of Calcium and Bile salts on the Pancreatic Lipase Hydrolysis of Triglyceride Emulsions Stabilized with Lecithin. F. J. Alvarez and V. J. Stella, Pharm. Res., 6, 449-457 (1989). Pancreatic Lipase-Catalyzed Hydrolysis of Esters of Hydroxymethyl Phenytoin Dissolved in Various Metabolized Vehicles, Dispersed in Micellar Systems, and in Aqueous Suspensions. F. J. Alvarez and V. J. Stella, Pharm. Res., 6, 555-563 (1989). Kinetics of Hydrolysis of Fetindomide (NSC-373965), bis-N,N'phenylalanyloxymethyl Prodrug of Mitindomide (NSC-284356); an Unexpected Catalytic Effect of Generated Formaldehyde. F. Sendo, C. M. Riley and V. J. Stella, Int. J. Pharmac. 45, 207-216 (1988). Evaluation of a Cumulative Time/Temperature Indicator System. Valentino. J. Stella and Robert. A. Myers, J. Pharm. Tech., 12, 106-116 (1988). Mechanism of Degradation of the Antineoplastic Agent, Clomesone (2chloroethyl(methylsulfonyl)methanesulfonate, NSC-338947). A Kinetic and Mechanistic Study. P. E. Kennedy, C. M. Riley and V. J. Stella, Int. J. Pharmac., 48, 179-188 (1988). A Novel Drug Delivery System: Microspheres of Hyaluronic Acid Derivatives. L M. Benedetti, E.M. Topp and V.J. Stella, in "Biomedical and Biotechnological Advances in Industrial Polysaccharides" V. Crescenzi, I.C.M. Dea et al., (Eds.), Gordon and Breach, New York, 1989, pp. 27-33.
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Characterization of Polymeric Films Prepared from Ester Derivatives of Hyaluronic Acid. J. A. Hunt, V.J. Stella, and E.M. Topp, in "Biomedical and Biotechnological Advances in Industrial Polysaccharides" V. Crescenzi, I.C.M. Dea et al., (Eds.), Gordon and Breach, New York, 1989, pp. 55-61. Chemical Stability of Pentostatin (NSC-218321), a Cytotoxic and Immunosuppressant Agent. L. A. Al-Razzak, A. Benedetti, W. Waugh and V. J. Stella, Pharm. Res., 7, 452-460 (1990). The Nucleophilicity of Dextrose, Sucrose, Sorbitol, and Mannitol with pnitrophenyl Esters in Aqueous Solution. R. B. Killion and V. J. Stella, Int. J. Pharmac. 66,149-155(1990). Stability of Carmethizole Hydrochloride, NCS-602668, an Experimental Cytotoxic Agent. V. J. Stella, A. Benedetti, W. A. Waugh, and R. B. Killion, Int. J. Pharmac., 71,.157-165 (1991) Mechanism of Hydrolysis, and Structure-Stability Relationship of Enaminones as Potential Prodrugs of Model Primary Amines. V. J. Stella and V. H. Naringrekar, J. Pharm. Sci., 79, .138-146 (1990). On the Mechanism of Isomerization of Cephalosporin Esters. W. F. Richter, Y. H. Chong, and V. J. Stella, J. Pharm. Sci., 79, 185-186 (1990). Mechanism of Degradation of the Investigational Cytotoxic Agent, Cyclodisone (NSC-348948). V. J. Stella, W. Waugh, K. Umprayn and C. M. Riley, Int. J. Pharmac., 66, 253-262 (1990). Stability and Solubility of 2-Chloro-2',3'-dideoxyadenosine. L. A. Al-Razzak, and V. J. Stella, Int. J. Pharmac., 60, 53-60 (1990). Diffusion and Drug Release in Polymer Films Prepared from Ester Derivatives of Hyaluronic Acid. J. A. Hunt, H.N. Joshi, V. J. Stella and E. M. Topp. J. Cont. Rel.,12, 159-169, (1990). Microspheres of Hyaluronic Acid Esters--Fabrication Methods and In Vitro Hydrocortisone Release. L M. Benedetti, V.J. Stella, and E.M. Topp. J. Cont. Rel., 13, 33-41 (1990). Experimental Determination of Diffusion Coefficients in Dilute Aqueous Solution Using the Method of Hydrodynamic Stability. M. Z. Southard, L. J. Dias, K. J. Himmelstein and V. J. Stella, Pharm. Res., 8, 1489-1494 (1991). Dissolution of Ionizable Drugs into Unbuffered Solution: A Comprehensive Model for Mass Transport and Reaction in the Rotating Disk Geometry. M. Z.
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Southard, D. W. Green, V. J. Stella, and K J. Himmelstein, Pharm. Res., 9, 58-69 (1992). 80. Stability, compatibility, and plasticizer extraction of taxol (NSC-125973) injection diluted in infusion solutions and stored in various containers. W. N. Waugh, L. A. Trissel and V. J. Stella. Amer. J. Hosp. Pharm., 48,1520-1524 (1991). Hydrolysis of Pharmaceutically Relevant Phosphate Monoester Monoanions: Correlation to an Established Structure-Reactivity Relationship. A.S. Kearney and V.J. Stella, J. Pharm. Sci., J. Pharm. Sci., 82, 69-72 (1993). The Anomalous Hydrolytic Behavior of 1-Phenylvinyl Phosphate. A.S. Kearney and V.J. Stella, Pharm. Res., 9, 378-384 (1992). The In Vitro Enzymatic Labilities of Chemically Distinct Phosphomonoesters Prodrugs. A.S. Kearney and V.J. Stella, Pharm. Res., 9, 497-503 (1992). Synthesis and Evaluation of Some Water Soluble Prodrugs and Derivatives of Taxol with Antitumor Activity. A.E. Mathew, M. Mejillano, J.P. Nath, R. H. Himes and V.J. Stella, J. Med. Chem., 35, 145-151 (1992). The Use of Oil-in Water Emulsions as a Vehicle for Parenteral Drug Administration. R.J. Prankerd and V.J. Stella, J. Par. Sc. & Tec., 44, 139-149 (1990) In Vitro and In Vivo Behavior of Phenytoin Prodrugs. K. Terada, S. Martodihardjo, E. Fukuoka and V.J. Stella, Rec. Dev. Pharm. Pharmaceutical Tech., 164-173 (1990) Targeting of Orally Administered Lipophilic Drugs to the Lymphatic System, V. J. Stella, W. N. A. Charman and R. A. Myers, Proceedings of the 17th International Symposium on Controlled Release of Bioactive Materials, 184-185 (1990) Evolution of Formulation Practices, V.J. Stella, Drug Dev. Ind. Pharm., 16, 26272633 (1990). A Kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogs, J. Fassberg and V.J. Stella, J. Pharm. Sci., 81, 676-684 (1992). Dosage Forms from Polymeric Prodrugs: Hydrocortisone Esters of Hyaluronic Acid. L M. Benedetti, H. N. Joshi, L. Goei, J. A. Hunt, L. Callegaro, V.J. Stella, and E.M. Topp. New Polymeric Materials, 3, 41-48 (1991).
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Blood and Lymph Transport of DDT after Oral and Parenteral Administration to Anaesthetized Rats. C. M. O'Driscoll, R. A. Myers and V. J. Stella, Int. J. Pharmac., 73, 177-183 (1991). Factors Influencing the Precipitation time of Phenytoin in the presence of DDMS, one of its Prodrugs. D. G. Muller, V. J. Stella, and A. P. Lotter, Int. J. Pharmac., 75, 201-209 (1991). Systemic Bioavailability of Penclomedine (NSC-338720), Oil-in Water Emulsions Administered Intraduodenally to Rats. R. A. Myers, and V. J. Stella, Int. J. Pharmac., 78, 217-226 (1992). Factors Affecting the Lymphatic Transport of Penclomedine (NSC-338720), a Lipophilic Cytotoxic Drug: Comparison to DDT and Hexachlorobenzene. R. A. Myers, and V. J. Stella, Int. J. Pharmac., 80, 51-62 (1992). Methylprednisolone Esters of Hyaluronic Acid in Ophthalmic Drug Delivery: In Vitro and In Vivo Release Studies. K. Kyyronen, L. Hume, L. Benedetti, A. Urtti., E. Topp, and V. J. Stella, Int. J. Pharmac., 80, 161-169 (1992). Drug Release from Membranes of Hyaluronic Acid and Its Esters. H. N. Joshi, V. J. Stella and E. M. Topp, J. Cont. Rel., 20, 109-122 (1992). Is ICRF-187 ((+)1,2-bis(3,5-dioxopiperazinyl-1-yl)propane) Unusually Reactive for an Imide. J. Sisco and V. J. Stella, Pharm. Res., 9, 1076-1082 (1992). An Unexpected Hydrolysis pH-Rate Profile, at pH values less than 7, of the Labile Imide, ICRF-187; (+)1,2-bis(3,5-dioxopiperazinyl-1-yl)propane. J. Sisco and V. J. Stella, Pharm. Res., 9, 1209-1214 (1992). Kinetics and Mechanism of Isomerization of Cyclosporin A. I. R. Oliyai and V. J. Stella, Pharm. Res., 9, 617-622 (1992). Drug Release from Hydrocortisone Esters of Hyaluronic Acid: Influence of Ester Hydrolysis Rate on Release Rate, L. Goei, L. Benedetti, F. Biviano, L. Callegaro, E. Topp, and V. J. Stella, Proc. 4th Int. Conf. Poly. Med: Biomed. Pharm. Appl., Technomic Publishing, Lancaster, PA, 1992, pp. 85-92. Polymeric Prodrugs: Recent Experience with Devices Formed from Steroid Esters of Hyaluronic Acid, H. Joshi, L. Hume, L. Benedetti, L. Callegaro, V. J. Stella, and E. Topp, Proc. 4th Int. Conf. Poly. Med: Biomed. Pharm. Appl., Technomic Publishing, Lancaster, PA, 1992, pp. 93-101. The Determination of the Amphiphilic Properties of a Prodrug (DDMS) of Phenytoin in Aqueous Media, D. G. Muller, V. J. Stella and A. P. Lotter, Int. J. Pharmac., 86, 175-186 (1992)
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Enzymic and Non-enzymic Hydrolysis of a polymeric Prodrug: Hydrocortisone Esters of Hyaluronic Acid, L. G. Rajewski, A. A. Stinnett, V. J. Stella and E. M. Topp, 80, 205-213 (1992) Kinetics of the Acid Catalyzed Hydrolysis of O6-Benzylguanine, M. Safadi, D. S. Bindra, T. Williams, R. C. Moschel and V. J. Stella, Int. J. Pharmac., 90, 239-246 (1993). Rapid Expansion from Supercritical Solutions: Application to Pharmaceutical Processess, E. M. Phillips and V. J. Stella, Int. J. Pharmac., 94, 1-10 (1993). Characterization of Sulphoalkyl Ether Derivatives of -Cyclodextrin by Capillary Electrophoresis with Indirect UV Detection, R. J. Tait, D. J. Skanchy, D. O. Thompson, N. C. Chetwyn, D. A Dunshee, R. A. Rajewski, V. J. Stella and J. F. Stobaugh, J. Pharm. Biomed. Anal., 9, 615-622 (1992). A Liquid Chromoatgraphic Method for the Determination of the Enantiomeric Purity of the Anticancer Drug, 9-Amino-20(S)-camptothecin, J. Kagel, V. J. Stella and C. Riley, J. Pharm. Biomed. Anal., 11, 793-802 (1993). A Numerical Convective-Diffusion Model for the Dissolution of Neutral Compounds Under Laminar Flow Conditions, S. Neervannan, J. Reinert, V. J. Stella and M. Z. Southard, Int. J. Pharmac., 96, 167-174 (1993). Phosphoryloxymethyl Carbamates and Carbonates-Novel Water-Soluble Prodrugs for Amines and Hindered Alcohols, M. Safadi, R. Oliyai and V. J. Stella, Pharm. Res., 10, 1350-1355 (1993). Plasma Pharmacokinetics of the Lactone and Carboxylate Forms of 20(S)Camptothecin in Anesthetized Rats, D. O. Scott, D. S. Bindra and V. J. Stella, Pharm. Res. 10, 1451-1457 (1993). Diffusion of Macromolecules in Membranes of Hyaluronic Acid Esters, D. Papini, V. J. Stella and E. M. Topp, J. Cont. Rel., 27, 47-57 (1993). Gellan -Based Systems for Ophthalmic Sustained Delivery of Methylprednisolone, Y. D. Sanzgiri, S. Maschi, V. Crescenzi, L. Callegaro, E. M. Topp and V. J. Stella, J. Control. Rel., 26, 195-201 (1993). Evaluation of Mucoadhesive Properties of Hyaluronic Acid Benzyl Esters, Y. D. Sanzgiri, E. M. Topp, L. Benedetti and V. J. Stella, Int. J. Pharm., 107, 91-97 (1994).
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Kinetics of Acid-Catalyzed Degradation of Cyclosporin A and its Analogs in Aqueous Solution, R. Oliyai, M. Safadi, P. G. Meier, M-K Hu, D. H. Rich and V. J. Stella, Int. J. Petide Protein Res., 43, 239-247 (1994). Degradation of O6-Benzylguanine in Aqueous Polyethylene Glycol (PEG) 400 Solutions; Concerns with Formaldehyde in Peg 400, D. Bindra, T. D. Williams and V. J. Stella, Pharm. Res, 11, 1060-1064 (1994). A Convective-Diffusion Model for Dissolution of Two Noninteracting Drug Mixtures from Cocompressed Pellets Under Laminar Hydrodynamic Conditions, S. Neervannan, M. Z. Southard and V. J. Stella, Pharm. Res., 11, 1288-1295 (1994). Dependence of Dissolution Rate on Surface Area: Is a Simple Linear Relationship Valid for Co-compressed Drug Mixtures, S. Neervannan, M. Z. Southard and V. J. Stella, Pharm. Res., 11, 1391-1395 (1994). Factors Affecting the Deamindation of Vancomycin in Aqueous Solutions, A. S. Antipas, D. Vander Velde and V. J. Stella, Int. J. Pharm., 109, 261-269 (1994). The Importance of Structural Factors on the Rate and Extent of N,O-Acyl Migration in Cyclic and Linear Peptides, R. Oliyai, T. J. Siahaan and V. J. Stella, Pharm. Res., 12, 323-328 (1995). Urinary and Biliary Disposition of the Lactone and Carboxylate Forms of 20(S)Camptothecin in Rats, D. O. Scott, D. S. Bindra, S. C. Sutton and V. J. Stella, Drug Met. Disp., 22, 438-442 (1994). Kinetics of Rearrangement and Hydrolysis of Amino Acid Derivatives of Prazosin, N. L. Pochopin, W. N. Charman and V. J. Stella, Int. J. Pharm., 105, 169-176 (1994). Amino Acid Derivatives of Dapsone as Water Soluble Prodrugs, N. L. Pochopin, W. N. Charman, N. L. Pochopin and V.J. Stella, Int. J. Pharm., 121, 157-167 (1995). Pharmacokinetics of Amino Acid Prodrugs of Dapsone in Rabbits, N. L. Pochopin, W. N. Charman and V. J. Stella, Drug Met. Disp., 22, 770-775 (1994). Ocular Sustained Delivery of Prednisolone using Hyaluronic Acid Benzyl Ester Films, L. R. Hume, H. Y. K. Lee, L. Benedetti, Y. D. Sanzgiri, E. M. Topp and V. J. Stella, Int. J. Pharm., 111, 295-298 (1994). Effect of pH on Theophylline Release from Partially Esterified Alginic Acid Matrices, L. D. Simon, L. Ruiz-Cardona, E. M. Topp and V. J. Stella, Drug Dev. Ind. Pharm., 20, 2341-2351 (1994).
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Determination of the Position of the Ester Bond in a Micellar Prodrug of Phenytoin, D. G. Müller, V. J. Stella and A. P. Lötter, Int. J. Pharm., 102, 109-116 (1994). The Effect of SBE4--CD on I.V. Methylprednisolone Pharmacokinetics in Rats: Comparison to a Co-Solvent Solution and Two Water Soluble Prodrugs, V. J. Stella, H. Y. Lee and D. O. Thompson, Int. J. Pharm., 120, 189-195 (1995). The Effect of SBE4--CD on I.M. Prednisolone Pharmacokinetics and Tissue Damage in Rabbits: Comparison to a Co-Solvent Solution and a Water Soluble Prodrug, V. J. Stella, H. Y. Lee and D. O. Thompson, Int. J. Pharm., 120, 197-204 (1995). Sulfobutyl Ether -Cyclodextrin (SBE--CD) in Eyedrops Improves the Tolerability of a Topically Applied Pilocarpine Prodrug in Rabbits, T. Jarvinen, K. Jarvinen, A. Urtti, D. Thompson and V. J. Stella, J. Ocul. Pharmacol. Ther., 11, 95-106 (1995). The Effect of a Modified -Cyclodextrin, SBE4--CD, on the Aqueous Stability and Ocular Absorption of Pilocarpine, T. Jarvinen, K. Jarvinen, D. Thompson and V. J. Stella, Cur. Eye Res., 13, 897-905 (1994). Application of Benzyl Hyaluronate Membranes as Wound Dressings: Evaluation of Water Vapor and Gas Permeabilities and Mechanical Properties, L. RuizCardona, Y. D. Sanzgiri, V. J. Stella and E. M. Topp, Biomaterials, 17, 16391643 (1996). Sulfobutyl Ether -Cyclodextrin as a Chiral Discriminator for Use with Capillary Electrophoresis, R. J. Tait, D. O. Thompson, V. J. Stella and J. F. Stobaugh, Anal. Chem., 66, 4013-4018 (1994). Derivatives, SBE4--CD and HP--CD, Increase the Oral Bioavailability of Cinnarizine in Beagle Dogs, T. Jarvinen, K. Jarvinen, N. Schwarting and V. J. Stella, J. Pharm. Sci., 84, 295-299 (1995). Preliminary Toxicology and Histopathology of Sulfoalkyl Ether -Cyclodextrin Derivatives, R. Rajewski, G. Traiger, J. Bresnahan, V. J. Stella and D. O. Thompson, J. Pharm. Sci., 84, 927-932 (1995). The Effect of a Parenterally Safe, Anionic -Cyclodextrin Derivative, Variably Substituted Alkylsulfonates (SBE4--CD), on I.V. Methylprednisolone Pharmacokinetics in Rats, V. J. Stella, H. K. Lee and D. O. Thompson, Proc. 7th Int. Cyclodextrin Symp., 365-368 (1994).
-Cyclodextrin
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The Effect of a Parenterally Safe, Anionic -Cyclodextrin Derivative, SBE4-CD, on I.M. Tissue Damage and Prednisolone Pharmacokinetics in Rabbits, V. J. Stella, H. K. Lee and D. O. Thompson, Proc. 7th Int. Cyclodextrin Symp., 369372 (1994). The Analysis of Anionically Modified Cyclodextrins by Capillary Electrophoresis, V. J. Stella, E. Luna, R. J. Tait, J. F. Stobaugh and D. O. Thompson, Proc. 7th Int. Cyclodextrin Symp., 198-201 (1994). Different Mode of Interaction of Chlorpromazine with Sulphated and Sulphoalkylated Cyclodextrins and Effects on Erythrocyte Membranes, K. Shiotani, K. Uehata, K. Ninomiya, T. Irie, K. Uekama, D. O. Thompson and V. J. Stella, Proc. 7th Int. Cyclodextrin Symp., 492-495 (1994). Effect of SBE4--CD, a Sulfobutyl Ether -Cyclodextrin, on the Stability and Solubility of O6-Benzylguanine (NSC-637037) in Aqueous Solutions, B. A. Gorecka, D. S. Bindra, Y. D. Sanzgiri and V. J. Stella, Int. J. Pharm., 125, 55-61 (1995). Structural Factors Affecting O,N-Acyl Transfer in O-Peptide Prodrugs of Peptides, R. Oliyai and V. J. Stella, Bioorg. Med. Chem. Let. 5, 2735-2740 (1995). Differential Effects of Sulfate and Sulfobutyl Ether of -Cyclodextrin on Erythrocycte Membranes In Vitro, K. Shiotani, K. Uehata, T. Irie, K. Uekama, D. O. Thompson, and V. J. Stella, Pharm. Res., 12, 78-84 (1995). Evaluation of the Utility of Capillary Electrophoresis (CE) for the Analysis of Sulfobutylether Cyclodextrin Mixtures, E. A. Luna, E. R. N. Bornancini, R. J. Tait, D. O. Thompson, J. F. Stobaugh, R. A. Rajewski, and V. J. Stella, J. Pharm. Biomed. Analysis, 15 (1) 63-71(1996). The Interaction of Charged and Uncharged Drugs with Neutral (HP--CD) and Anionically Charged (SBE7--CD) -Cyclodextrins, K. Okimoto. R. R. Rajewski, K. Uekama, J. J. Jona and V. J. Stella, Pharm. Res., 13, 256-264 (1996). Modified -Cyclodextrin (SBE7--CD) with Viscous Vehicle Improves the Ocular Delivery and Tolerability of Pilocarpine Prodrug in Rabbits. P. Jarho, K. Jarvinen, A. Urtti, V. J. Stella, T. Jarvinen, J. Pharm. Pharmacol., 48, 263-269 (1996). Derivatives of Melphalan Designed to Enhance Drug Accumulation in Cancer Cells. L. Kupczyk-Subotkowska, K. Tamara, D. Pay, T. J. Siahaan, V. J. Stella and R. T. Borchardt, J. Drug Targeting, 4, 359-370 (1997).
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Isolation and Magnetic Resonance Characterization of Monosubstituted Sulfobutyl ether -Cyclodextrin. E. A. Luna, D. Vander Velde, R. J. Tait, D. O. Thompson, R. A. Rajewski and V. J. Stella, Carbohyd. Res. 299, 111-118 (1997). Fractionation and Characterization of Sulfobutyl ether -Cyclodextrin Mixtures. E. A. Luna, E. R. Bornancini, D. O. Thompson, R. A. Rajewski and V. J. Stella, Carbohyd. Res. 299, 103-110 (1997). Esterase-Sensitive Cyclic Prodrugs of Peptides: Evaluation of an Acyloxyalkoxy Pro-moiety in a Model Hexapeptide. G. M. Pauletti, S. Gangwar, F. W. Okumu, T. J. Siahaan, V. J. Stella and R. T. Borchardt, Pharm. Res., 13, 1613-1621 (1996). Synthesis of a Novel. Esterase-Sensitive Cyclic Prodrug of a Model Hexapeptide Using an Acyloxyalkoxy Promoiety. S. Gangwar, G. M. Pauletti, T. J. Siahaan, V. J. Stella and R. T. Borchardt, J. Org. Chem., 62, 1356-1362 (1997). Effect of Alkyl Chain Length and Degree of Substitution on the Complexation of Sulfoalkyl Ether -Cyclodextrins with Steroids. V. Zia, E. R. Bornancini, E. A. Luna, R. A. Rajewski and V. J. Stella, J. Pharm. Sci., 86, 220-224 (1997). The Effect of Conformation on Membrane Permeability of an Acyloxyalkyloxylinked Cyclic Prodrug of a Model Hexapeptide. S. Gangwar, S. D. S. Jois, T. J. Siahaan, D. G. Vander Velde, V. J. Stella and R. T. Borchardt, Pharm. Res., 13, 1657-1662 (1996). SBE7--CD, a New, Novel and Safe Polyanionic -Cyclodextrin Derivative: Characterization and Biomedical Applications. V. J. Stella, Proc. 8th Int. Cyclodextrin Symp., Kluwer Academic Publishers, J. Szejtli and L. Szente (eds.), 471-476 (1996). SBE7--CD with Viscous Vehicle Improves the Ocular Delivery and Tolerability of Pilocarpine Prodrug, P. Jarho, K. Jarvinen, A. Urtti, V. J. Stella, T. Jarvinen, Proc. 8th Int. Cyclodextrin Symp., Kluwer Academic Publishers, J. Szejtli and L. Szente (eds.), 399-402 (1996). Effect of Alkyl Chain Length and Degree of Substitution on Complexation of Sulfoalkyl -Cyclodextrins with Testosterone and Progesterone. V. Zia, E. R. Bornancini, E. A. Luna, R. A. Rajewski, and V. J. Stella, Proc. 8th Int. Cyclodextrin Symp., Kluwer Academic Publishers, J. Szejtli and L. Szente (eds.), 259-262 (1996). Characterization of Sulfobutyl Ether -Cyclodextrin Mixtures. E. A. Luna, E. R. Bornancini, D. O. Thompson, R. A. Rajewski, and V. J. Stella, Proc. 8th Int. Cyclodextrin Symp., Kluwer Academic Publishers, J. Szejtli and L. Szente (eds.), 133-136 (1996).
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Protein Transport Across Hyaluronic Acid ester Membranes: Evaluation of Ribonuclease A as a Potentially Useful Model Protein. L. D. Simon, W. N. Charman, S. A. Charman, and V. J. Stella, J. Controlled Rel., 45, 273-285 (1997). Conjugation with L-Glutamic Acid for Brain Drug Delivery, T. Sakaeda, Y. Tada, T. Sugiwara, T. Ryu, F. Hirose, T. Yoshikawa, K. Hirano, L. KupczykSubotkowska, T. Siahaan, K. Audus and V. J. Stella, Proc. Intern. Symp. Rel. Bioact. Mater., 23, 607-608 (1996). Prodrug Strategies to Enhance the Intestinal Absorption of Peptides. S. Gangwar, G. M. Pauletti, B. Wang, T. J. Siahaan, V. J. Stella and R. T. Borchardt, Drug Discovery Today, 2, 22-29 (1997). Novel Esterase-Sensitive Cyclic Prodrugs of a Model Hexapeptide Having Enhanced Membrane Permeabilty and Enzymatic Stability. S. Gangwar, G. M. Pauletti, B. Wang, T. J. Siahaan, V. J. Stella and R. T. Borchardt, Proc. XIV th Int. Symp. Med. Chem., 27-34 (1997). Synthesis of an Esterase-Sensitive Prodrug of a Model Hexapeptide Having Enhanced Membrane Permeability and Enzymatic Stability Using an Acyloxyalkoxy Promoiety. S. Gangwar, G. M. Pauletti, T. J. Siahaan, V. J. Stella and R. T. Borchardt, in Peptidomimetic Protocols (W. M. Kazmierski, Ed.), The Humana Press, Totowa, NJ, pp. 37-52, 1998. The Use of Cyclodextrins in Ophthalmic Formulations of Diprivefrin. P. Jarho, K. Jarvinen, A. Urtti, V. J. Stella, T. Jarvinen, Int. J. Pharm., 153, 225-233 (1997). Increased Shelf-Life of Fosphenytoin: Solubilization of a Degradant, Phenytoin, through Complexation with (SBE)7M--CD. S. Narisawa and V. J. Stella, J. Pharm. Sci., 87, 926-930 (1998). Comparison of the Effects of Potential Parenteral Vehicles for Poorly Water Soluble Anti-Cancer Drugs (Organic Cosolvents and Cyclodextrin Solutions) on Cultured Endothelial Cells (HUV-EC). N. Medlicott, K. A. Foster, K. L. Audus, S Gupta and V. J. Stella, J. Pharm. Sci., 87, 1138-1143 (1998). Design and Evaluation of an Osmotic Pump Tablet (OPT) for Prednisolone, a Poorly water Soluble Drug using (SBE)7M--CD. K. Okimoto, M. Miyake, M. Yasumura, N. Ohnishi. R. A. Rajewski, V. J. Stella, T. Irie and K. Uekama. Pharm. Res. 15, 1562-1568 (1998). Release of Testosterone from an Osmotic Pump Tablet Utilizing (SBE)7M-Cyclodextrin as Both a Solubilizing and Osmotic Agent. . K. Okimoto, R. A. Rajewski, and V. J. Stella, J. Control. Rel. 58, 29-38 (1999).
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Stability of Rifabutin in an Extemporaneously Compounded Oral Liquid. J. L. Haslam, K. L. Egodage, W. Chen, R. A. Rajewski and V. J. Stella, Amer. J. Health-System Pharm.,56, 333-336 (1999). Some Relationships between the Physical Properties of Various 3-Acyloxymethyl Prodrugs of Phenytoin to Structure: Potential In Vivo Performance Implications. V. J. Stella, S. Martodihardjo and V. M. Rao, J. Pharm. Sci., 87, 1235-1241 (1998). Halohydrin Analogues of Cryptophycin 1: Synthesis and Biological Activity, G. I. Georg, S. M. Ali, V. J. Stella, W. N. Waugh, and R. H. Himes, Bioorg. Med. Chem. Lett., 8, 1959-1962 (1998). A Novel Prodrug Approach for Tertiary Amines: Synthesis and Preliminary Evaluation of N-Phosphonooxymethyl Prodrugs, J. P. Krise, J. Zygmunt, G. I. Georg, and V. J. Stella, J. Med. Chem.,42, 3094-3100 (1999). A Novel Prodrug Approach for Tertiary Amines, 2: Physicochemical and In Vitro Enzymatic Evaluation of N-Phosphonooxymethyl Prodrugs, J. P. Krise, S. Narisawa, and V. J. Stella, J. Pharm. Sci. 88, 922-927 (1999). A Novel Prodrug Approach for Tertiary Amines, 3: In Vivo Evaluation of two NPhosphonooxymethyl Prodrugs in Rats and Dogs, J. P. Krise, W. N. Charman, S. A. Charman, and V. J. Stella, J. Pharm. Sci., 88, 928-932 (1999). Design and Evaluation of an Osmotic Pump Tablet (OPT) for Chlorpromazine using (SBE)7M--CD, . K. Okimoto, A. Ohike, R. Ibuki, O. Aoki, N. Ohnishi, T. Irie, K. Uekama, R. A. Rajewski, and V. J. Stella. Pharm. Res.16, 549-554 (1999). Thermal Properties and Processing of (SBE)7M--CD as a Freeze-Drying Excipient in Pharmaceutical Formulations, D. Q. Ma, R. A. Rajewski, and V. J. Stella. STP Pharma Sci., 9, 261-266 (1999). Factors Affecting Membrane-Controlled Drug Release for an Osmotic Pump Tablet (OPT) Utilizing (SBE)7M--CD as Both a Solubilizer and Osmotic Agent, K. Okimoto, A. Ohike, R. Ibuki, O. Aoki, N. Ohnishi, R. A. Rajewski, V. J. Stella T. Irie, and K. Uekama. J. Cont. Rel. 60, 311-319 (1999). Aqueous Solubility and Dissolution Rate Does Not Adequately Predict In Vivo Performance: A Probe Utilizing Some N-Acyloxymethyl Phenytoin Prodrugs, V. J. Stella, S. Martodihardjo and V. M. Rao, J. Pharm. Sci., 88, 775-779 (1999). The Use of (SBE)7m--CD (Captisol®) as a Solubilizing and Osmotic Agent for Controlled and Complete Oral Delivery of Poorly Waters Soluble Drugs, V. J. Stella, K. Uekama, T. Irie, V. M. Rao, E. A. Zannou, R. A. Rajewski, S. Shiraishi,
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and K. Okimoto, in Proceedings of the 9th International Symposium on Cyclodextrins, Santiago de Compostela, Spain,J. J. Torres Lababdeira and J. L. Vila Jato (Eds), Kluwer Publishing, 459-462 (1999). 177. Design and Evaluation of a Porosity Controlled Osmotic Pump Tablet for Chlorpromazine using (SBE)7m--CD, K. Okimoto, M. Miyake, O. Aoki, N. Ohnishi, T. Irie, K. Uekama , R. A. Rajewski, and V. J. Stella, in Proceedings of the 9th International Symposium on Cyclodextrins, Santiago de Compostela, Spain,J. J. Torres Lababdeira and J. L. Vila Jato (Eds), Kluwer Publishing, 285288 (1999). Effect of (SBE)7m--CD on Methylprednisolone Transport Across Ethylcellulose Microporous Membranes, E. A. Zannou, S. Shiraishi, V. M. Rao, and V. J. Stella, in Proceedings of the 9th International Symposium on Cyclodextrins, Santiago de Compostela, Spain,J. J. Torres Lababdeira and J. L. Vila Jato (Eds), Kluwer Publishing, 445-448 (1999). A Novel Chemical Delivery System for Brain Targeting, T. Yoshikawa, T. Sakaeda (nee Kakutani), T. Sugawara, K. Hirano, V. J. Stella, Adv. Drug Del. Rev., 36, 255-275 (1999). Variation in the Diffusion and Release of Ribonuclease Through and from Esterified Hyaluronic Acid Membranes: Effect of Changes in Matrix Characteristics. L.D. Simon, V.J. Stella, W.N. Charman, and S.A. Charman, J. Cont. Release, 61, 159-164 (1999). Mechanisms Controlling Diffusion and Release of Model Proteins Through and from Partially Esterified Hyaluronic Acid Membranes. L.D. Simon, V.J. Stella, W.N. Charman, and S.A. Charman, J. Cont. Release, 61, 267-279 (1999). New Injectable Melphalan Formulations Utilizing (SBE)7M--CD or HP--CD, D. Q. Ma, R. A. Rajewski, and V. J. Stella. Int. J. Pharm. 189, 227-234 (1999). Mechanisms of Drug Release from Hyaluronic Acid Esters, L. Rajewski, E. Topp, E. Phillips and V. J. Stella,in Redefining Hyaluronan, G. Abatangelo and P. H. Weigel (Eds), Exerpta Medica, International Congress Series 1196, 149-161 (2000). Green Process Concepts for the Pharmaceutical Industry, B. Subramaniam, S. Siam, R. Rajewski and V. J. Stella, In P. Anastas, L. Heine and T. Williamson (eds.) Green Processing; ACS Symposium Series 766,.pp. 96-110; 2000 American Chemical Society, Washington, D.C. Cyclodextrin-Catalyzed Deacetylation of Spironolactone is pH and Cyclodextrin Dependent, Pekka Jarho, David Vander Velde and Valentino J. Stella, J. Pharm. Sci., 89, 241-249 (2000).
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Comparison Between (SBE)7M--CD and HP--CD in the Stabilization of Two Anti-neoplastic Agents Melphalan and Carmustine, D. Q. Ma, R. A. Rajewski, D. Vander Velde and V. J. Stella. J. Pharm. Sci. 89, 275-287 (2000). Enhancement of Transport of D-Melphalan Analogue by Conjugation with LGlutamate Across Bovine Brain Microvessel Endothelial Cell Monolayers. T. Sakaeda, T. J. Siahaan, K. L. Audus and V. J. Stella, J. Drug Targeting, 8, 195204 (2000). Degradation Pathways of a Peptide Boronic Acid Derivative, 2-Pyz-(CO)-PheLeu-B(OH)2, S. Wu, W. Waugh and V. J. Stella, J. Pharm. Sci., 89, 758-765 (2000). Effect of Conformation on the Rate of Deamidation of Vancomycin in Aqueous Solutions. A. S. Antipas, D. G. Vander Velde, T. J. Siahaan, V. J. Stella, J. Pharm. Sci., 89, 742-750 (2000). Thermodynamics of Binding of Neutral Molecules to Sulfobutyl Ether Cyclodextrins (SBE--CDs): The Effect of Total Degree of Substitution. V. Zia, R. A. Rajewski and V. J. Stella, Pharm. Res., 17, 936-941 (2000). Conjugation with L-Glutamate for in vivo Brain Drug Delivery. T. Sakaeda, Y. Tada, T. Sugiwara, T. Ryu, F. Hirose, T. Yoshikawa, K. Hirano, L. KupcyzkSubotkowska, T. J. Siahaan, K. L. Audus and V. J. Stella, J. Drug Targeting, 9, 23-37, 2001 Controlled and Complete Release of a Model Poorly Water Soluble Drug, Prednisolone, from HPMC Matrix Tablets Using (SBE)7m--CD as a Solubilizing Agent. V. M. Rao, J. L. Haslam and V. J. Stella, J. Pharm. Sci.,90, 807-816 (2001). Flow and Tableting Properties of (SBE)7M--CD, S. Sotthivirat, J. L. Haslam and V. J. Stella, Proceedings of the 10th International Symposium on Cyclodextrins, Ann Arbor, MI, Kluwer Publishing, CD publication.. The Osmotic Properties of Sulfobutylether and Hydroxypropyl Derivatives of Cyclodextrins, E. A. Zannou, W. H. Streng and V. J. Stella, , Pharm. Res., 18, 1226-1231 (2001). Effect of Cyclodextrin Charge on Complexation of Neutral and Charged Substrates: Comparison of (SBE)7m--CD to HP--CD. V. Zia, R. A. Rajewski and V. J. Stella, Pharm. Res., 18, 667-673 (2001). The Effect of Cyclodextrin and pH on Cyclodextrin-Catalyzed Deacetylation of Spironolactone, P. Jarho, D. Vander Velde and V. J. Stella, Proceedings of the
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10th International Symposium on Cyclodextrins, Ann Arbor, MI, Kluwer Publishing, CD publication. 197. Some Unique Properties and Pharmaceutical Applications of Anionically Charged Cyclodextrins, V. J. Stella, Proceedings of the 10th International Symposium on Cyclodextrins, Ann Arbor, MI, Kluwer Publishing, CD publication. The Pharmaceutical Use of Captisol®: Some Surprising Observations, Valentino J. Stella, Venkatramana M. Rao and Erika A. Zannou, J. Incl. Phen. Macro. Chem., 44, 29-33 (2002). Cyclodextrin Utility Number; A Tool to Assess the Feasibility of Using Cyclodextrins as Solubilizers of Poorly Soluble Drugs, V. Rao and V. J. Stella, J. Pharm. Sci., 92, 927-932 (2003). Degradation of NSC-281612 (4-[bis[2-[methylsulfonyl)oxy]ethyl]amino]-2methyl-benzaldehyde, an Experimental Antineoplastic Agent: the Effect of pH, Solvent Composition, (SBE)7m--CD to HP--CD on Stability, M. Jumaa, L. Chimilio, S. Chinnaswamy, S. Silchenko and V. J. Stella, J. Pharm. Sci., 93, 532539 (2004) A Mechanistic and Kinetic Study of the E-Ring Hydrolysis and Lactonization of a Novel Phosphoryloxymethyl Prodrug of Camptothecin, Bradley A. Hanson, Richard L. Schowen, and Valentino J. Stella, Pharm. Res. 20, 1031-8 (2003) Photostability of 2-hydroxymethyl-4,8-dibenzo[1,2-b:5,4-b']dithiophene-4,8dione (NSC 656240), a potential anticancer drug. S. Silchenko, C. Schoneich, B. J. Carlson, V. J. Stella, Int J Pharm., 264, 97-105 (2003). Binding Constants for Aromatic Amino Acids and Their Dipeptides with Sulfobutyl Ether -Cyclodextrin Determined Using Capillary Electrophoresis, M. Miyajima, T. Ozeki and V. J. Stella, J. Drug Del. Sci. Tech., Kinetics and Mechanism of Degradation of Epothilone D: An Experimental Anticancer Agent, M. Jumaa, C. Carlson, L. Chimilio and V. J. Stella, J. Pharm. Sci, 93, 2953-2961 (2004). Phase Solubility and Structure of the Inclusion Complexes of Prednisolone and 6-Methylprednisolone with Various Cyclodextrins, K. L. Larsen, F. L. Aachmann, R. Wimmer, V. J. Stella and U. M. Kjolner, J. Pharm. Sci., 94, 507515 (2005). Applicability of (SBE)7m--CD in Contolled-Porosity Osmotic Pump Tablets (OPTs), K. Okimoto, A. Ohike, R. Ibuki, T. Irie, K. Uekama, R. A. Rajewski, and V. J. Stella, Int. J. Pharm., 286, 81-8 (2004)
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Synthesis and characterization of new sulfoalkyl-alkyl-ether cyclodextrin derivatives, S. Tongiani, D. Vander Velde and V. J. Stella, Proceedings of the 12th International Cyclodextrin Symposium, Montpellier, France, 141-144 (2004). Influence of SBE--CD ethylation on 9-NO2-Paullone solubilization. S. Silchenko, S. Tongiani, and V. J. Stella. Proceedings of the 12th International Cyclodextrin Symposium, Montpellier, France, 375-378 (2004). Analysis of adaphostin-chemcially modified cyclodextrins complexes with NMR diffusion measurements. S. Tongiani, D Vander Velde, S. Silchencko, L. Chimilio and V. J. Stella. Proceedings of the 12th International Cyclodextrin Symposium, Montpellier, France, 499-502 (2004). Binding constants for aromatic amino acids and their dipeptides with SBE7--CD using CE chromatography. M Miyajima, T. Ozeki and V. J. Stella Proceedings of the 12th International Cyclodextrin Symposium, Montpellier, France, 495-498 (2004).
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Papers Submitted or in Preparation 1.. Long-Term Stability and Formulation of a Novel Phosphoryloxymethyl Prodrug of Camptothecin, Bradley A. Hanson and Valentino J. Stella, J. Pharm. Sci., submitted. Chemical Stability and Conformational Analysis of Vancomycin Analog 1Nacetyl Vancomycin, A. S. Antipas, D. G. Vander Velde, S. D. S. Jois, V. J. Stella, J. Pharm. Sci., submitted. Plasma Pharmacokinetics of the Lactone and Carboxylate Forms of the POM Prodrug of Camptothecin and Camptothecin in Rats, Bradley A. Hanson, Michelle P. McIntosh, David G. Kosednar, Roger A. Rajewski, and Valentino J. Stella, in final preparation. Kinetics of E-Ring Opening and Closing of 21-Amino, 21-desoxy Camptothecin in Aqueous Solution, M. Josan, S. Silchenko and V. J. Stella, in preparation. A Case for Prodrugs, Valentino J. Stella, in " Prodrugs: Challenges and Rewards" V. J. Stella (ed.) AAPS Press, 2005. Parenteral Prodrugs, Jeffrey Hemenway and Valentino J. Stella, in " Prodrugs: Challenges and Rewards" V. J. Stella (ed.) AAPS Press, 2005. A Functional Group Approach to Prodrugs: Alcohols and Phenols, Sandeep Dhareshwar and Valentino J. Stella, in " Prodrugs: Challenges and Rewards" V. J. Stella (ed.) AAPS Press, 2005.
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A Functional Group Approach to Prodrugs: Amides, Imides and Hydantoins, Victor Guarino and Valentino J. Stella, in " Prodrugs: Challenges and Rewards" V. J. Stella (ed.) AAPS Press, 2005. A Functional Group Approach to Prodrugs: Macromolecules, William Marinaro and Valentino J. Stella, in " Prodrugs: Challenges and Rewards" V. J. Stella (ed.) AAPS Press, 2005. A Functional Group Approach to Prodrugs: Alcohols and Phenols, Sandeep Dhareshwar and Valentino J. Stella, in " Prodrugs: Challenges and Rewards" V. J. Stella (ed.) AAPS Press, 2005. Fosphenytoin: A Prodrug of Phenytoin, , in " Prodrugs: Challenges and Rewards" V. J. Stella (ed.) AAPS Press, 2005. " Prodrugs: Challenges and Rewards" V. J. Stella (ed.) AAPS Press, 2005.
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13. Sulfoalkyl Ether-Alkyl Ether Cyclodextrin Derivatives, their Synthesis, NMR Characterization and Binding of 6-Methylprednisolone, Serena Tongiani, David Vander Velde, Tetsuya Ozeki, and Valentino J. Stella, J. Pharm. Sci., submitted 14. Prodrug Strategies for Improving Drug-Like Properties, Valentino J. Stella, in " Optimizing Drug Like Properties During Lead Optimization" AAPS Press, 2005.
Reviews and Book Chapters 1. 2. The Chemical Modification of Drugs to Overcome Pharmaceutical Problems. Valentino J. Stella, Australian J. Pharm. Sci., NS2/2, 57-63 (1973). Pro-Drugs: An Overview and Definition. V. Stella. Chapter 1, Book #14 of the American Chemical Society Symposium Series (Pro-Drugs Novel Drug Delivery System, T. Higuchi and V. Stella, eds.) 1975. Drug Substances in Particular Prodrugs - Problems and Methods of Approach. Valentino J. Stella in "Formulation and Preparation of Dosage Forms", J. Polderman, ed., Elsevier, North Holland Biomedical Press, p. 91-111, 1977. Prodrugs: The Control of Drug Delivery Via Bioreversible Chemical Modification. V.J. Stella, T.J. Mikkelson and J.D. Pipkin, in "Drug Delivery Systems", R.L. Juliano, ed., Oxford University Press. Chapter 4, 1980. Critique of Prodrugs and Site-Specific Drug Delivery, V.J. Stella and K.J. Himmelstein in "Optimization of Drug Delivery", H. Bundgaard, A.B. Hansen and H. Kofod, eds., Alfred Benzon Symposium 17, Munksgaard, Copenhagen, 1982.
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Trends in Prodrug Research. V.J. Stella, V.H. Naringrekar and W.N.A. Charman, Pharm. International, 5, 276-279 (1984). Prodrugs: Do They Have Advantages in Clinical Practice? V.J. Stella, W.N.A. Charman and V.H. Naringrekar, Drugs, 29, 455-473 (1985). Prodrugs: A Chemical Approach to Targeted Drug Delivery: Valentino J. Stella and Kenneth J. Himmelstein in "Directed Drug Delivery: A Multidisciplinary Problem", R.T. Borchardt, A.J. Repta and V.J. Stella, eds., Humana Press, pp. 247-267 (1985). Site-Specific Drug Delivery Via Prodrugs. V.J. Stella and K.J. Himmelstein, in "Prodrugs", H. Bundgaard, ed., Elsevier Biomedical Press ,pp.177-198(1985). F
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