Free Expert Witness Designation - District Court of Colorado - Colorado

Case 1:03-cv-02608-WDM-MJW

Document 71-3

Filed 11/30/2006

Page 1 of 26

EXHIBIT "C"

Case 1:03-cv-02608-WDM-MJW

Document 71-3

Filed 11/30/2006

Page 2 of 26
2005

CURRICULUM VITAE
EMANUEL RUBIN, M.D. Date of Birth: EDUCATION College Medical School Internship Residency Dazian Research Fellow in Pathology Advanced Clinical Fellow, American Cancer Society MILITARY SERVICE BOARD CERTIFICATION Villanova University - B.S. Harvard Medical School - M.D. Boston City Hospital, Boston, MA Children's Hospital of Philadelphia Philadelphia, PA Mount Sinai Hospital New York, NY Mount Sinai Hospital New York, NY U. S. Navy, Lieutenant Diplomate of American Board of Pathology (Anatomic and Clinical Pathology) The Mount Sinai Hospital, New York, NY Assistant Attending Pathologist Associate Attending Pathologist Attending Pathologist and Director of Hospital Pathology Service Pathologist-in-Chief Hahnemann University Hospital, Philadelphia, PA. 1962-1964 1964-1968 1968-1972 1971-1976 1950 1954 1954-1955 1957-1958 1958-1960 1960-1962 December 5, 1928 New York, NY

1955-1957 1962

HOSPITAL APPOINTMENTS

1

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 3 of 26

Director of Laboratories Thomas Jefferson University Hospital Philadelphia, PA

1977-1986

Attending Physician-in-Chief (Pathology) ACADEMIC APPOINTMENTS Mount Sinai School of Medicine of the City University of New York Professor of Pathology Irene Heinz and John LaPorte Given Professor of Pathology and Chairman of the Department Hahnemann University School of Medicine, Philadelphia, Pa. Professor and Chairman, Department of Pathology and Laboratory Medicine University of Pennsylvania School of Medicine, Philadelphia, Pa. Adjunct Professor of Biochemistry and Biophysics Jefferson Medical College, Philadelphia Gonzalo E. Aponte Professor of Pathology Chairman of the Department of Pathology and Cell Biology Chairman of the Department of Pathology, Anatomy and Cell Biology Gonzalo E. Aponte Professor of Pathology and Chairman Emeritus of the Department of Pathology, Anatomy and Cell Biology

1986-

1966-1972

1972-1976

1977-1986

1977-1988

1986-2003 1986-1994 1994-2003 2003-Present

HONORS

American Medical Writer's Association Award For Best Medical Textbook of the Year Doctor Honoris Causa University of Barcelona The F.K. Mostofi Distinguished Service Award
2

1989 1994 1996

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 4 of 26

of U.S..-Canadian Academy of Pathology NIH MERIT Award Tom Kent Award of Group for Research in Pathology Education (GRIPE) Doctor Honoris Causa University of Naples, Italy NAMED LECTURER Maude L. Menten Centennial Lecture University of Pittsburgh School of Medicine Whipple Lecture University of Rochester Medical Center 1996-2006 2001 2003

1987 1987

Chippy Friedman Memorial Lecture - Haifa University, Technion Medical School, Haifa, Israel 1988 Maude Abbott Lecture U. S.-Canadian Academy of Pathology Reginald G. Mason Memorial Lecture University of Utah School of Medicine Marcus Wallenberg Symposium, Keynote Address: Alcohol and the Cell, Lund, Sweden Jack M. Layton Lecture University of Arizona School of Medicine Clifford Toren Memorial Lecture University of South Alabama School of Medicine Donald Svoboda Memorial Lecture University of Kansas Medical School CONSULTANTSHIPS NIAAA - Biomedical Review Committee NIAAA (NIH)- Biochemistry, Physiology and Medicine Subcommittee of Alcohol Biomedical Research Review Committee Ad Hoc Member NIH - Pathology B NHLBI National Task Force for Alcohol and Health, Department of Health, Education and Welfare 1971 1977 1985 1990 1992 1992 1994 1994 1995 1970-1974 1981-1985

1990-1994

3

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 5 of 26

Representative of Association of Pathology Chairmen to Council of Academic Societies Medical Advisory Council, Alcoholic Beverage Medical Research Foundation EDITORIAL POSITIONS EDITOR-IN-CHIEF CHAIRMAN OF EDITORIAL BOARD AND REVIEWING EDITOR FIELD EDITOR (PATHOLOGY) ASSISTANT EDITOR Laboratory Investigation Alcoholism: Clinical and Experimental Research

1991-1994 1992-

1982-1995

Quarterly Journal of Studies in Alcohol Federation Proceedings FASEB Journal Addiction Biology

EDITORIAL BOARDS

Laboratory Investigation Human Pathology Gastroenterology American Journal of Alcohol and Drug Abuse Substance and Alcohol Abuse Medicine and Chirurgie Digestives Alcohol and Alcoholism Alcohol Health and Research World Addiction Biology

MEMBERSHIPS

American Association of Pathologists U.S.-Canadian Academy of Pathology College of American Pathologists American Society for Biochemistry and Molecular Biology American College of Toxicology American College of Physicians American Gastroenterological Association American Association for the Study of Liver Diseases International Association for the Study of the Liver Research Society on Alcoholism International Society for Biomedical Research on Alcoholism Association of Pathology Chairmen (Vice-President 1988-90)

4

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 6 of 26

PUBLICATIONS ORIGINAL CONTRIBUTIONS 1. 2. 3. 4. 5. 6. Hutterer, F., Rubin, E., Singer, E.J. and Popper, H.:Alkali-soluble and insoluble collagen in infant, adult and cirrhotic liver. Proc. Soc. Exp. Biol. Med. 102:534-536, 1959. Rubin, E. and Zak, F.G.: Pneumocystis carinii pneumonia in the adult. New England J. Med. 262:1315-1317, 1960. Rubin, E. and Strauss, L.: Congenital absence of the right pulmonary artery. Am. J. Cardiol. 6: 344-350, 1960. Popper, H., Rubin, E., Krus, S. and Schaffner, F.: Postnecrotic cirrhosis in alcoholics. Gastroenterology 39: 669-685, 1960. Hutterer, F., Rubin, E., Singer, E.J. and Popper, H.: Quantitative relation of cell proliferation and fibrogenesis in the liver. Cancer Res. 21: 205-215, 1961. Moschcowitz, E., Rubin, E. and Strauss, L.: Hypertension of the pulmonary circulation due to congenital glomoid obstruction of the pulmonary arteries. Am. J. Path. 39: 7593, 1961. Rubin, E. and Strauss, L.: Occlusive intrapulmonary vascular anomaly in the newborn. A cause of congenital pulmonary hypertension. Am. J. Path. 39: 145-161, 1961. Zak, F.G. and Rubin, E.: Histiocytic medullary reticulosis. Am. J. Med. 31: 813-819, 1961. Rubin, E., Hutterer, F., Gall, E. Cs. and Popper, H.: Nature of increased protein and DNA in chronic hepatic injury. Nature 192: 886-887, 1961. Paronetto, F., Rubin, E. and Popper, H.: Local formation of gamma globulin in the diseased liver, and its relation to hepatic necrosis. Lab. Invest. 11: 150-158, 1962. Andrade, Z.A., Santana, S. Jr. and Rubin, E.: Hepatic changes in advanced schistosomiasis. Gastroenterology 42: 393-400, 1962. Hutterer, F., Rubin, E., Gall, E. Cs. and Popper, H.: Cortisone effect in stages of hepatic injury. A cytochemical, autoradiographic and histologic study. Exp. Molec. Path. 1: 85-95, 1962. Rubin, E., Krus, S. and Popper, H.: Pathogenesis of postnecrotic cirrhosis in alcoholics. Arch. Path. 73: 288-299, 1962. Rubin, E., Schaffner, F. and Popper, H.: Localization of the basic injury in primary biliary cirrhosis. JAMA 183: 331-334, 1963. Rubin, E., Camara, J., Grayzel, D.M. and Zak, F.G.: Radiation- induced cardiac fibrosis. Am. J. Med. 34: 71-75, 1963. Rubin, E., Hutterer, F. and Popper, H.: Cell proliferation and fiber formation in chronic carbon tetrachloride intoxication. A morphologic and chemical study. Am. J. Path. 715728, 1963.
5

7. 8. 9. 10. 11. 12.

13. 14. 15. 16.

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 7 of 26

17.

Rubin, E., Hutterer, F., Danon, G. and Popper, H.: Deoxyribonucleic acid turnover in a heterogeneous population. The life span of hepatic ductular cells. Lab. Invest. 12: 657662, 1963. Rubin, E., Kohan, P., Fusayoshi, T. and Jacobson, J.H.: Experimental hepatic siderosis following portacaval shunt. Proc. Soc. Exp. Biol. Med. 115: 350-352, 1964. Rubin, E., Masuko, K., Goldfarb, S. and Zak, F.G.: The role of cell proliferation in hepatic carcinogenesis. Proc. Soc. Exp. Biol. Med. 115: 381-384, 1964. Hutterer, F., Rubin, E. and Popper, H.: Mechanism of collagen resorption in reversible fibrosis. Exp. Molec. Path. 3: 215-233, 1964. Rubin, E.: The origin and fate of proliferated bile ductular cells. Exp. Molec. Path. 3: 279-386, 1964. Masuko, K., Rubin, E. and Popper, H.: Proliferation of bile ducts in cirrhosis. Arch. Path. 78: 421-431, 1964. Rubin, E., Gevirtz, N.R., Kohan, P., Fusayoshi, T. and Jacobson, J.H., II: Liver cell damage produced by portacaval shunts. Proc. Soc. Exp. Biol. Med. 118: 235-237, 1965. Popper, H., Rubin, E., Gardiol, D., Schaffner, F. and Paronetto, F.: Drug-induced liver disease. A penalty for progress. Arch. Int. Med. 115: 128-136, 1965. Rubin, E., Schaffner, F. and Popper, H.: Primary Biliary Cirrhosis. Chronic nonsuppurative destructive cholangitis. Am. J. Path. 46: 387-407, 1965. Rubin, E., Gevirtz, N.R., Richter, P. and Jacobson, J.H., II: Erythrocyte survival after experimental portacaval shunt. Proc. Soc. Exp. Biol. Med. 119: 1216-1217, 1965. Levy, R.N., Sawitzky, A., Florman, A.L. and Rubin, E.: Fatal aplastic anemia after hepatitis. Report of 5 cases. New England J. Med. 273: 1118-1123, 1965. Rubin, E.: Autoradiographic characterization of sulfated acid mucopolysaccharides in experimental cirrhosis. J. Histochem. Cytochem. 14: 688-689, 1966. Rubin, E.: Differential blockade of deoxyribonucleic acid synthesis by ethionine. Lab. Invest. 15: 1509-1519, 1966. Rubin, E. and Lieber, C.S.: Early fine structural changes in the human liver induced by alcohol. Gastroenterology 52: 1-13, 1967. Rubin, E. and Popper, H.: The evolution of human cirrhosis deduced from observations in experimental animals. Medicine 46: 163-183, 1967. Lieber, C.S. and Rubin, E.: Alcoholic fatty liver in man on a high protein and low fat diet. Am. J. Med. 44: 200-206, 1968. Rubin, E., Hutterer, F. and Popper, H.: Experimental hepatic fibrosis without hepatocellular regeneration. A kinetic study. Am. J. Path. 52: 111-119, 1968. Rubin, E., Hutterer, F. and Lieber, C.S.: Ethanol increases hepatic smooth endoplasmic reticulum and drug metabolizing enzymes. Science 159: 1469-1470, 1968.
6

18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34.

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 8 of 26

35.

Rubin, E., Hutterer, F., Ohshiro, T. and Jacobson, J.H., II: Effect of experimental portacaval shunt on hepatic drug metabolizing enzymes. Proc. Soc. Exp. Biol. Med. 127: 444-447, 1968. Rubin, E. and Lieber, C.S.: Alcohol-induced hepatic injury in non-alcoholic volunteers. N. Engl. J. Med. 278: 869-876, 1968. Rubin, E., Gottlieb, C. and Vogel, P.: Syndrome of hepatitis and aplastic anemia. Am. J. Med. 45: 88-97, 1968. Rubin, E. and Lieber, C.S.: Hepatic microsomal enzymes in man and rat: Induction and inhibition by ethanol. Science 162: 690-691, 1968. Iturriaga, H., Posalaki, I. and Rubin, E.: Aggravation of hepatic necrosis by lysosomal injury. Exp. Molec. Path. 10: 231-239, 1969. Lieber, C. S. and Rubin, E.: Alcoholic fatty liver in man on a high protein and low fat diet. N. Engl. J. Med. 200: 705-708, 1969. Rubin, E., Florman, A.L., Degnan, T. and Diaz, J.: Hepatic injury in chronic hypervitaminosis A. Am. J. Dis. Child. 119: 132-138, 1970. Rubin, E., Bacchin, P., Gang, H. and Lieber, C.S.: Induction and inhibition of hepatic microsomal and mitochondrial enzymes by ethanol. Lab. Invest. 22: 569-580, 1970. Hutterer, F., Eisenstadt, M. and Rubin, E.: Turnover of hepatic collagen in reversible and irreversible fibrosis. Experienta 26: 244, 1970. Lieber, C.S., Rubin, E., DeCarli, L.M., Misra, P.S. and Gang, H.: Effects of pyrazole on hepatic function and structure. Lab. Invest. 22: 615-621, 1970. Lieber, C.S., Rubin, E. and DeCarli, L.M.: Hepatic microsomal ethanol oxidation system (MEOS): Differentiation from alcohol dehydrogenase and NADPH oxidase. Biochem. Biophys. Res. Commun. 40: 858-865, 1970. Rubin, E., Gang, H., Misra, P.S. and Lieber, C.S.: Inhibition of drug metabolism by acute ethanol intoxication. A hepatic microsomal mechanism. Am. J. Med. 49: 801806, 1970. Rubin, E., Beattie, D.S. and Lieber, C.S.: Effect of ethanol on the biogenesis of mitochondrial membranes and associated mitochondrial functions. Lab. Invest. 23: 620627, 1970. Rubin, E., Lieber, C.S., Alvares,A.P., Levin, W. and Kuntzman, R.: Ethanol binding to hepatic microsomes: Its increase by ethanol consumption. Biochem. Pharmacol. 20: 229-231, 1971. Rubin, E., Gang, H. and Lieber, C.S.: Interaction of ethanol and pyrazole with hepatic microsomes. Biochem. Biophys. Res. Commun. 42: 1-8, 1971. Misra, R.S., Lefevre, A., Ishii, H., Rubin, E. and Lieber, C.S.: Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rat. Am. J. Med. 51: 346-351, 1971.

36. 37. 38. 39. 40. 41. 42. 43. 44. 45.

46.

47.

48.

49. 50.

7

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 9 of 26

51. 52.

Song, S.K. and Rubin, E.: Ethanol produces muscle damage in human volunteers. Science 175: 327-328, 1972. Gang, H., Lieber, C.S. and Rubin, E.: Aniline hydroxylase microassay suitable for needle biopsy specimens. Effect of phosphate and pyrophosphate on aniline hydroxylation. J. Pharmacol. Exp. Therap. 183: 218-225, 1972. Rubin, E., Rybak, R.J., Lindenbaum, J., Gerson, C.D., Walker, G. and Lieber, C.S.: Ultrastructural changes in the small intestine induced by ethanol. Gastroenterology 63: 801-814, 1972. Kamath, S.A. and Rubin, E.: Interaction of calcium with microsomes: A modified method for the rapid isolation of rat liver microsomes. Biochem. Biophys. Res. Commun. 49: 52-59, 1972. Cederbaum, A., Lieber, C.S., Beattie, D.S. and Rubin, E.: Effect of chronic ethanol ingestion on mitochondrial permeability and the transport of reducing equivalents. Biochem. Biophys. Res. Commun. 49: 649-655, 1972. Gang, H., Lieber, C.S. and Rubin, E.: Ethanol increases glycosyl transferase activity in the hepatic Golgi apparatus. Nature 243: 123-125, 1973. Cederbaum, A.I. and Rubin, E.: Role of citrate in stimulation of the fatty acid shuttle for the transport of reducing equivalents into the mitochondria. Biochem. Biophys. Res. Commun. 52: 980-986, 1973. Cederbaum, A.I., Lieber, C.S., Toth, A., Beattie, D.S. and Rubin, E.: Effects of ethanol and fat on the transport of reducing equivalents into rat liver mitochondria. J. Biol. Chem. 248: 4977-4986, 1973. Kamath, S.A. and Rubin, E.: The exchange of phospholipids between subcellular organelles of the liver. Arch. Biochem. Biophys. 158: 312-322, 1973. Cederbaum, A.I., Lieber, C.S., Beattie, D.S. and Rubin, E.: Characterization of shuttle mechanisms for the transport of reducing equivalents into mitochondria. Arch. Biochem. Biophys. 158: 763-781, 1973. Gang, H., Cederbaum, A.I. and Rubin, E.: Sterospecificity of ethanol exidation. Biochem. Biophys. Res. Commun. 54: 264-269, 1973. Cederbaum, A.I., Lieber, C.S. and Rubin, E.: Effect of acetaldehyde on activity of shuttles for the transport of reducing equivalents into the mitochondria. FEBS Letters 37: 89-92, 1973. Rubin, E. and Lieber, C.S.: Experimental alcoholic hepatitis: A new primate model. Science 182: 712-713, 1973. Beattie, D.S., Patton, G.M. and Rubin, E.: The control of delta-aminolevulinic acid synthetase in rat liver mitochondria. Enzyme 16: 252-257, 1973. Rubin, E. and Lieber, C.S.: Fatty liver, alcoholic hepatitis and cirrhosis produced by alcohol in primates. New England J. Med. 290: 128-135, 1974. Cederbaum, A.I. and Rubin, E.: Effects of pyrazole, 4-bromopyrazole and 4methylpyrazole on mitochondrial function. Biochem. Pharmacol. 23: 203-213, 1974.
8

53.

54.

55.

56. 57.

58.

59. 60.

61. 62.

63. 64. 65. 66.

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 10 of 26

67. 68. 69. 70. 71. 72. 73.

Cederbaum, A.I. and Rubin, E.: Effects of clofibrate on mitochondrial function. Biochem. Pharmacol. 23: 1985-1996, 1974. Cederbaum, A.I., Lieber, C.S. and Rubin, E.: The effects of acetaldehyde on mitochondrial function. Arch. Biochem. Biophys. 161: 26-39, 1974. Kamath, S.A. and Rubin, E: Effects of carbon tetrachloride and phenobarbital on plasma membranes: Enzymes and phospholipid transfer. Lab. Invest. 30: 494-499, 1974. Kamath, S.A. and Rubin, E.: Alteration in the rate of phospholipid exchange between cell membranes. Lab. Invest. 30: 500-504, 1974. Kamath, S.A. and Rubin, E.: A short procedure to measure phospholipid exchange in mitochondria and microsomes. Anal. Biochem. 59: 172-177, 1974. Swartz, M.H., Repke, D.I., Katz, A.M. and Rubin, E.: Effects of ethanol on Ca-binding and Ca-uptake by cardiac microsomes. Biochem. Pharmacol. 23: 2369-2376, 1974. Cederbaum, A.I., Lieber, C.S. and Rubin, E.: Effects of chronic ethanol treatment on mitochondrial function. Damage to coupling site 1. Arch. Biochem. Biophys. 165: 560569, 1974. Williams, J.W., Tada, M., Katz, A.M. and Rubin, E.: Effects of ethanol and acetaldehyde on the (Na+ + K+)-activated ATPase activity of cardiac plasma membranes. Biochem. Pharmacol. 24: 27-32, 1975. Kamath, S.A. and Rubin, E.: The use of cation-bound microsomes for studies of protein synthesis. Lab. Invest. 32: 10-16, 1975. Cederbaum, A.I. and Rubin, E.: Differential effects of acetate on palmitate and octanoate oxidation. Segregation of acetyl coA pools. Arch. Biochem. Biophys. 166: 618-628, 1975. Puszkin, S. and Rubin, E.: Adenosine diphosphate effect on contractility of human muscle actomyosin. Inhibition by ethanol and acetaldehyde. Science 188: 1319-1320, 1975. Cederbaum, A.I., Lieber, C.S., Beattie, D.S. and Rubin, E.: Effect of chronic ethanol ingestion on fatty acid oxidation by hepatic mitochondria. J. Biol. Chem. 250: 51225129, 1975. Cederbaum, A.I., Lieber, C.S. and Rubin, E.: Effect of acetaldehyde on fatty acid oxidation and ketogenesis by hepatic mitochondria. Arch. Biochem. Biophys. 169: 2941, 1975. Lieber, C.S., DeCarli, L.M. and Rubin, E.: Sequential production of fatty liver, hepatitis and cirrhosis in subhuman primates fed ethanol with adequate diets. Proc. Nat. Acad. Sci. 72: 437-441, 1975. Cederbaum, A.I., Pietruszko, R., Hempel, J., Becker, F.F. and Rubin, E.: Characterization of a nonhepatic alcohol dehydrogenase from rat hepatocellular carcinoma and stomach. Arch. Biochem. Biophys. 171: 348-360, 1975.

74.

75. 76.

77.

78.

79.

80.

81.

9

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 11 of 26

82.

Rubin, E., Lieber, C.S., Altman, K., Gordon, G.G. and Southern, A.L.: Prolonged chronic ethanol consumption increases testosterone metabolism in the liver. Science 191: 563-564, 1976. Cederbaum, A.I. and Rubin, E.: Protective effect of cysteine on the inhibition of mitochondrial functions by acetaldehyde. Biochem. Pharmacol. 25: 963-973, 1976. Cederbaum, A.I., Madhavan, T.V. and Rubin, E.: Effect of chronic clofibrate administration on mitochondrial fatty acid oxidation. Biochem. Pharmacol. 25: 12851292, 1976. Cederbaum, A.I. and Rubin, E.: Kinetic properties of alcohol dehydrogenase in hepatocellular carcinoma and normal tissue of rat. Cancer Res. 36: 2274-2277, 1976. Rubin, E., Katz, A.M., Lieber, C.S., Stein, E.P. and Puszkin, S.: Muscle damage produced by chronic alcohol consumption. Am. J. Path. 83: 499-516, 1976. Cederbaum, A.I., Becker, F.F. and Rubin, E.: Ethanol metabolism by a transplantable hepatocellular carcinoma. J. Biol. Chem. 251: 5366-5374, 1976. Cederbaum, A.I., Lieber, C.S. and Rubin, E.: Effect of chronic ethanol consumption and acetaldehyde on partial reactions of oxidative phosphorylation and CO2 production. Arch. Biochem. Biophys. 176: 525-537, 1976. Cederbaum, A.I. and Rubin, E.: Mechanism of the protective action of cysteine and penicillamine against acetaldehyde-induced mitochondrial injury. Biochem. Pharmacol. 25: 2179-2185, 1976. Gordon, G.G., Altman, K., Southern, A.L., Rubin, E. and Lieber, C.S.: Effects of alcohol (ethanol) administration on sex hormone metabolism in normal men. New England J. Med. 295: 793-797, 1976. Cederbaum, A.I. and Rubin, E.: Fatty acid oxidation, substrate shuttles and activity of the citric acid cycle in hepatocellular carcinomas of varying differentiation. Cancer Res. 36: 2980-2987, 1976. Puszkin, S. and Rubin, E.: Effects of ADP, ethanol and acetaldehyde on the relaxing complex of human muscle and its adsorption by polystyrene particles. Arch. Biochem. Biophys. 177: 574-584, 1977. Cederbaum, A.I. and Rubin, E.: The oxidation of acetaldehyde by isolated mitochondria from various organs of the rat and hepatocellular carcinoma. Arch. Biochem. Biophys. 179: 46-66, 1977. Cederbaum, A.I. and Rubin, E.: Sensitivity to acetaldehyde of pyruvate oxidation by mitochondria from liver, kidney, brain and muscle. Biochem. Pharmacol. 26: 13491353, 1977. Retig, J.N., Kirchberger, M.A., Rubin, E. and Katz, A.M.: Effects of ethanol on calcium transport by microsomes phosphorylated by cyclic AMP-dependent protein kinase. Biochem. Pharmacol. 26: 393-396, 1977. Cederbaum, A.I., Dicker, E. and Rubin, E.: Transfer and reoxidation of reducing equivalents as the rate limiting steps in the oxidation of ethanol by liver cells isolated from fed and fasted rats. Arch. Biochem. Biophys. 183: 638-646, 1977.
10

83. 84.

85. 86. 87. 88.

89.

90.

91.

92.

93.

94.

95.

96.

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 12 of 26

97.

Cederbaum, A.I., Dicker, E., Lieber, C.S. and Rubin, E.: Ethanol oxidation by isolated hepatocytes from ethanol-treated and control rats: Factors contributing to the metabolic adaptation after chronic ethanol consumption. Biochem. Pharmacol. 27: 7-15, 1977. Cederbaum, A.I., Dicker, E., Rubin, E. and Cohen, G.: The effect of dimethylsulfoxide and other hydroxyl radical scavengers on the oxidation of ethanol by rat liver microsomes. Biochem. Biophys. Res. Commun. 78: 1254-1262, 1977. Cederbaum, A.I., Rubin, E. and Cohen, G.: The effect of thiourea on microsomal oxidation of alcohols and associated microsomal functions. Biochemistry 18: 1187, 1979. Sun, A.S., Lawrence, J., Reinach, P.S. and Rubin, E.: 5' nucleotidase levels in normal and virus-transformed cells: Implications for cellular aging in vitro. Lab. Invest. 41: 14, 1979. Burke, J. P. and Rubin, E.: The effects of ethanol and acetaldehyde on the products of protein synthesis by liver mitochondria. Lab. Invest. 41: 393-400, 1979. Thayer, W.S. and Rubin, E.: Effects of chronic ethanol intoxication on oxidative phosphorylation in rat liver submitochondrial particles. J. Biol. Chem. 254: 7717-7723, 1979. Thayer, W.S., Ohnishi, T. and Rubin, E.: Characterization of iron-sulfur clusters in rat liver submitochondrial particles by electron paramagnetic resonance spectroscopy. Alterations produced by chronic ethanol consumption. Biochem. Biophys. Acta 591: 2236, 1980. Rottenberg, H., Robertson, D.E. and Rubin, E.: The effects of ethanol on the temperature dependence of respiration and ATPase activities of rat liver mitochondria. Lab. Invest. 42: 318-326, 1980. Rosa, J. and Rubin, E.: Effects of ethanol on amino acid uptake by rat liver cells. Lab. Invest. 43: 366-372, 1980. Giknis, M.L.A., Damjanov, I. and Rubin, E.: The differential transplacental effects of ethanol in four mouse strains. Neurobehav. Toxicol. 2: 235-237, 1980. Schanne, F.Z.X., Zucker, A.H., Farber, J.L. and Rubin, E.: A new in vitro model of alcohol-dependent liver cell necrosis. Science 212: 338-340, 1981. Waring, A.J., Rottenberg, H. and Rubin, E.: Membranes and phospholipids of liver mitochondria from chronic alcoholic rats are resistant to membrane disordering by alcohol. Proc. Nat. Acad. Sci. (USA) 78: 2582-2586, 1981. Giknis, M.L.A., Damjanov, I. and Rubin, E.: Ethanol narcophylaxis: Prolongation of ethanol-induced sleeping time by preconditioning. Res. Commun. Sub.Abuse 2: 85-92, 1981. Thayer, W.S. and Rubin, E.: Molecular alterations in the respiratory chain of rat liver mitochondria after chronic ethanol consumption. J. Biol. Chem. 256: 6090-6097, 1981.

98.

99.

100.

101. 102.

103.

104.

105. 106. 107. 108.

109.

110.

11

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 13 of 26

111.

Rottenberg, H., Waring, A.J. and Rubin, E.: Tolerance and cross-tolerance in chronic alcoholics: Reduced membrane binding of alcohol and drugs. Science 213: 583-584, 1981. Waring, A.J., Rottenberg, H., Ohnishi, T. and Rubin, E.: The effect of chronic ethanol consumption on temperature-dependent physical properties of liver mitochondrial membranes. Arch. Biochem. Biophys. 216: 51-61, 1982. Rottenberg, H., Waring, A.J. and Rubin, E.: The molecular basis of alcohol tolerance and drug cross-tolerance in chronic alcoholism. Biophys. J. 37: 14-16, 1982. Ponnappa, B.C., Waring, A.J., Hoek, J.B., Rottenberg, H. and Rubin, E.: Chronic ethanol ingestion increases calcium uptake and resistance to molecular disordering by ethanol in liver microsomes. J. Biol. Chem. 257: 10141-10146, 1982. Thayer, W.S. and Rubin, E.: Antimycin inhibition as a probe of mitochondrial function in isolated rat hepatocytes: Effects of chronic ethanol consumption. Biochem. Biophys. Acta 721: 328-335, 1982. Berman, W.J., Gil, J., Jennett, R.B., Tuma, D., Sorrell, M.F. and Rubin, E.: Ethanol, hepatocellular organelles and microtubules: A morphometric study in vivo and in vitro. Lab. Invest. 48: 760-767, 1983. Kelly-Murphy, S., Waring, A.J., Rottenberg, H. and Rubin, E.: Adaptive changes of erythrocyte membranes after chronic ethanol ingestion. Lab. Invest. 50: 174-183, 1984. Rottenberg, H., Waring, A.J. and Rubin, E.: Alcohol-induced tolerance in mitochondrial membranes. Science 223: 193, 1984. Ohnishi, S.T., Flick, J.L. and Rubin, E.: Ethanol increases calcium permeability of heavy sarcoplasmic reticulum of skeletal muscle. Arch. Biochem. Biophys. 223: 588-594, 1984. Dorio, R.J., Hoek, J.B. and Rubin, E.: Ethanol treatment selectively decreases amino acid transport in cultured hepatocytes. J. Biol. Chem. 259: 11430-11435, 1984. Ishii, Y., Ohnishi, S.T. and Rubin, E.: Action of ADP and ethanol on muscle proteins in vitro. Biochem. Pharmacol. 34: 203-210, 1985. Rottenberg, H., Robertson, D.E. and Rubin, E.: The effect of temperature and chronic ethanol feeding on the proton electrochemical potential and phosphate potential in rat liver mitochondria. Biochim. Biophys. Acta 809: 1-10, 1985. Taraschi, T.F., Wu, A. and Rubin, E.: Phospholipid spin probes measure the effects of ethanol on the molecular order of liver microsomes. Biochemistry 24: 7096-7101, 1985. Ponnappa, B., Hoek, J.B., Sarchet, K. and Rubin, E.: Dietary carbohydrate level determines the effect of chronic ethanol ingestion on rat pancreatic amylase content. J. Lab. Clin. Med. 107: 556-562, 1986. Taraschi, T.F., Ellingson, J.S., Wu, A., Zimmerman, R. and Rubin, E.: Membrane tolerance to ethanol is rapidly lost after withdrawal: A new model for studies of membrane adaptation. Proc. Nat. Acad. Sci. (USA) 83: 3669-3673, 1986.
12

112.

113. 114.

115.

116.

117. 118. 119.

120. 121. 122.

123.

124.

125.

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 14 of 26

126.

Ishii, Y., Lehrer, S., Ohnishi, S.T. and Rubin, E.: Effect of ethanol on tropomyosin in solution and in reconstituted thin filaments. Arch. Biochem. Biophys. 246: 765-771, 1986. Taraschi, T.F., Ellingson, J.S., Wu, A., Zimmerman, R. and Rubin, E.: Phosphatidylinositol from ethanol-fed rats confers membrane tolerance to ethanol. Proc. Nat. Acad. Sci. (USA) 83: 9398-9402, 1986. Ponnappa, B.C., Hoek, J.B., Waring, A.J. and Rubin, E.: Effect of ethanol on amylase secretion and cellular calcium homeostasis in pancreatic acini from normal and ethanolfed rats. Biochem. Pharmacol. 36: 69-79, 1987. Hoek, J. B., Thomas, A. P., Rubin, R. and Rubin, E.: Ethanol-induced mobilization of calcium by activation of phosphoInositide-specific phospholipase C in intact hepatocytes. J. Biol. Chem. 262: 682-691, 1987. Stubbs, C. D., Williams, B. W., Pryor, C. L. and Rubin, E.: Ethanol-induced modifications to membrane lipid structure: Effect on phospholipase A2-membrane interactions. Arch. Biochem. Biophys. 262: 560-573, 1988. Ellingson, J. S., Taraschi, T. F., Wu, A., Zimmerman, R. and Rubin, E.: Cardiolipin from ethanol-fed rats confers tolerance to ethanol in liver mitochondrial membranes. Proc. Natl. Acad. Sci. (USA) 85: 3353-3357, 1988. Ponnappa, B.C., Hoek, J.B., Jubinski, L. and Rubin, E.: Effect of chronic ethanol ingestion on pancreatic protein synthesis. Biochim. Biophys. Acta 966: 390-402, 1988. Dorio, R. J., Hoek, J. B., Rubin, E. and Forman, H. J.: Ethanol modulation of rat alveolar macrophage superoxide production. Biochem. Pharmacol. 37: 3528-3531, 1988. Nie, Y., Stubbs, C. D., Williams, B. W. and Rubin, E.: Ethanol causes decreased partitioning into biological membranes without changes in lipid order. Arch. Biochem. Biophys. 268: 349-359, 1989. Urbano-Marquez, A., Estruch, R., Navarro-Lopez, F., Grau, J. M., Mont, L. and Rubin, E.: The effects of alcoholism on skeletal and cardiac muscle. New England J. Med. 320: 409-415, 1989. Rooney, T. A., Hager, R., Rubin, E. and Thomas, A. P.: Short chain alcohols activate guanine nucleotide-dependent phosphoinositidase C in turkey erythrocyte membranes. J. Biol. Chem. 264: 6817-6822, 1989. Hoek, J. B., Ponnappa, B. C. and Rubin, E.: Dietary carbohydrates and chronic ethanol both affect rat pancreatic amylase levels. J. Lab. Clin. Med. 113: 248-249, 1989. Thomas, A. P., Sass, E. J., Tun-Kirchmann, T. T. and Rubin, E.: Ethanol inhibits electrically-induced calcium transients in isolated rat cardiac myocytes. J. Mol. Cell Cardiol. 21: 555-565, 1989. Stubbs, C. D., Williams, B. W., Boni, L. T., Hoek, J. B., Taraschi, T. F. and Rubin, E.: On the use of N-(7-nitrobenz-2-oxa-1.3-diazol-4-yl)phosphatidylethanolamine in the study of lipid polymorphism. Biochim. Biophys. Acta 986: 89-96, 1989.

127.

128.

129.

130.

131.

132. 133. 134.

135.

136.

137. 138.

139.

13

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 15 of 26

140.

Taraschi, T. F., Ellingson, J. S., Wu-Sun, A. and Rubin, E.: Rats withdrawn from ethanol rapidly re-acquire membrane tolerance after resumption of ethanol feeding. Biochim. Biophys. Acta 1021: 51-55, 1990. Ponnappa, B. C., Hoek, J. B., Jubinski, L. and Rubin, E.: Ethanol withdrawal stimulates protein synthesis in rat pancreatic lobules. Biochim. Biophys. Acta. 1036: 107-112, 1990. Janes, N., Rubin, E. and Taraschi, T. F.: 1H NMR dipolar echo decay spectroscopy: A sensitive probe of membrane structure. Biochem. J. 29: 8385-8388, 1990. Hoek, J.B., Taraschi, T.F., Higashi, K., Rubin, E. and Thomas, A. P.: Phospholipase C activation by ethanol in rat hepatocytes is unaffected by chronic ethanol feeding. Biochem. J. 272: 59-64, 1990. Cardellach, F., Taraschi, T.F., Ellingson, J. S., Stubbs, C. D., Rubin, E. and Hoek, J. B.: Maintenance of structural and functional characteristics of skeletal muscle mitochondria and sarcoplasmic reticular membranes after chronic ethanol treatment. Biochem. J. 274: 565-573, 1991. Stewart, G., Rubin, E. and Thomas, A.P.: Inhibition by cocaine of excitation-contraction coupling in isolated cardiac myocytes. Am. J. Physiol. 260: 50-57, 1991. Stubbs, C.D., Kisielewski, A.E. and Rubin, E.: Chronic ethanol ingestion modifies liver microsomal phosphatidylserine inducing resistance to hydrolysis by exogenous phospholipase A2. Biochim. Biophys. Acta 1070: 349-354, 1991. Ellingson, J.S., Janes, N., Taraschi, T.F. and Rubin, E.: The effect of chronic ethanol consumption on the fatty acid composition of phosphatidylinositol in rat liver microsomes as determined by gas chromatography and 1H NMR. Biochim. Biophys. Acta 1062: 199-205, 1991. Taraschi, T.F., Ellingson, J.S., Janes, N. and Rubin, E.: The role of anionic phospholipids in membrane adaptation to ethanol. Alcohol & Alcoholism 1: 241-245, 1991. György Hajnóczky, Christopher J. Buzas, Pál Pacher, Jan B. Hoek and Emanuel Rubin.: Alcohol and mitrochondria in cardiac apoptosis: mechanisms and visualization. Alcohol: Clin Exp Res, In Press Ala-Kokko, L., Gunzler, V., Hoek, J.B., Rubin, E. and Prockop, D.J.: Hepatic fibrosis in rats produced by carbon tetrachloride and dimethylnitrosamine: Observations suggesting immunoassays of serum for the 7S fragment of type IV collagen are a more sensitive index of liver damage than immunoassays for the NH2-terminal propeptide of type III procollagen. Hepatology 16: 167-172, 1992. Cardellach, F., Galofre, J., Grau, J.M., Casademont, J., Hoek, J.B., Rubin, E., and Urbano-Marquez, A.: Oxidative metabolism in muscle mitochondria from patients with chronic alcoholism. Ann. Neurol. 31: 515-518, 1992. Janes, N., Hsu, J.W., Rubin, E. and Taraschi, T.F.: Nature of alcohol and anesthetic action on cooperative membrane equilibria. Biochemistry 31:9467-9472, 1992.

141.

142. 143.

144.

145. 146.

147.

148.

149.

150.

151.

152.

14

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 16 of 26

153.

Wang, D.-C., Taraschi, T.F., Rubin, E. and Janes, N.: Configurational entropy is the driving force of ethanol action on membrane architecture. Biochim. Biophys. Acta 1145: 141-148, 1993. Slater, S.J., Cox, K.J., Lombardi, J.V., Ho, C., Kelly, M.B., Rubin, E., and Stubbs, C.D.: Inhibition of protein kinase C by alcohols and anesthetics. Nature 364: 82-84, 1993. Covarrubias, M., Rubin, E: Ethanol selectively blocks a non-inactivating K+ current expressed in Xenopus oocytes. Proc. Natl. Acad. Sci. USA 90:6957-6960, 1993. Ponnappa, B.C., Dodge, G.R., Dudkowski, B., Hoek, J.B., Iozzo, R.V., and Rubin, E.: Stimulation of protein synthesis in isolated pancreatic acini from chronically ethanol-fed rats is due to alterations in post-transcriptional regulation. Biochim. Biophys. Acta 1158:113-119, 1993. Fernandez-Sola, J., Estruch, R., Grau, J.M., Pare, J.C., Rubin, E., and Urbano-Marquez, A.: The relation of alcoholic myopathy to cardiomyopathy. Ann. Intern. Med. 120:529536, 1994. Slater, S.J., Kelly, M.B., Taddeo, F.J., Ho, C., Rubin, E., and Stubbs, C.D.: The modulation of protein kinase C activity by membrane lipid bilayer structure. J Biol. Chem. 269:4866-4871, 1994. Victorov, A.V., Janes, N., Moehren, G., Rubin, E., Taraschi, T.F. and Hoek, J.B.: Rapid transbilayer movement of phosphatidylethanol in unilamellar phosphatidylcholine vesicles. J. Amer. Chem. Soc. 116:4050-4052, 1994. Damjanov, I., Fenderson, B.A., Veloski, J.J. and Rubin, E.: Testing of medical students with open-ended, uncued questions. Human Pathol. 26:362-365, 1995. Urbano-Márquez, A., Estruch, R., Fernández-Solá, J., Nicolás, J.M.., Paré J.C. and Rubin, E. The greater risk of alcoholic cardiomyopathy and myopathy in women compared to men. J. Amer. Med. Assoc. 274:149-154, 1995. Estruch, R., Fernández-Solá, J., Sacanella, E., Paré, C. and Rubin, E., Urbano-Márquez, A.: Relationship between cardiomyopathy and liver disease in chronic alcoholism. Hepatology 22:532-538, 1995.

154. 155. 156.

157.

158.

159.

160. 161.

162.

163. Channareddy S., Jose SS., Eryomin VA., Rubin E., Taraschi TF., Janes N. Saturable ethanol binding in rat liver microsomes. J. Biol. Chem. 271(30):17625-8, 1996. 164. Nicolás, J., Rubin, E., Thomas, A.P. Ethanol and cocaine cause additive inhibitory effects on the calcium transients and contraction in single cardiomyocytes. Alcohol Clin. Exp. Res., 20(6):1077-1082, 1996. Fenderson, B.A., Damjanov, I., Robeson, M.R., Veloski, J.J., Rubin, E. The virtues of extended matching and uncued tests as alternatives to multiple choice questions. Human Pathology, 28:526-532, 1997. Fenderson, B.A., Damjanov, I., Robeson, M.R., Rubin, E. Relationship of students' perceptions of faculty to scholastic achievement: are popular instructors better educators? Human Pathology, 28:522-525, 1997.

165.

166.

15

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 17 of 26

167.

Fenderson, B.A., Mohammadreza, H., Damjanov, I., Rubin, E. Characteristics of Medical Students Completing an Honors Program in Pathology. Human Pathology 30 (11):1296-1301, 1999. Fenderson, B.A., Damjanov, I., Maxwell, K., Veloski, J.J., Rubin, E.:Teaching and Evaluation: Based on Keywords and Extended Matching Questions. Pathology Education 24 (1)17-29, 1999. Bokkala S., Rubin E., Joseph S.K.: Effect of Chronic Ethanol Exposure on Inositol Trisphosphate Receptors in WB Rat Liver Epithelial Cells. Alcoholism: Clinical and Experimental Research 23 (12) 1875-1883, 1999.

168.

169.

170. Solem, M., Almas, J., Rubin, E. and Thomas, A.: Changes in Activity and Regulation of the Cardiac Ca2+ Channel (L-type) by Protein Kinase C in Chronic Alcohol-Exposed Rats, Alcoholism: Clinical and Experimental Research, 24(8) 1145-1152, 2000. 171. Bokkala, S., Reis, H.M., Rubin, E., Joseph, S.K.: Effect of angiotensin II and ethanol on the expression of connexin 43 in WB fat liver cells. Biochem. J. 357 769-777, 2001. 172. Nicolas, J.M., Fernández-Solá, J., Estruch, R., Paré, C., Sacanella, E., Urbano-Márquez, A, and Rubin, E.: The effect of controlled drinking in alcoholic cardiomyopathy. Annals of Internal Medicine 136 (3) 192-200, 2002.

173. Pecherskaya, A., Rubin, E., and Solem, M.: Alterations in IGF1 signaling in cardiomyocytes from alcoholic rats. Alcoholism: Clinical and Experimental Research 26: 995-1002, 2002. 174. Fernández-Solá, J., Nicolás, J.M., Oriola, J., Sacanella, E., Estruch, R., Rubin, E, and Urbano-Márquez, A.: Angiotensin-converting enzyme gene polymorphism is associated with vulnerability to alcoholic cardiomyopathy. Annals of Internal Medicine 137:321-326, 2002

175.

Estruch, E., J., Sacanella, E., Badia, E., Antúnez, E., Nicolás, J.M., Fernández-Solá, J., Rotilio, D., de Gaetano, G., Rubin, E., and Urbano-Márquez, A.: Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of Wine on Inflammatory Markers. Atherosclerosis 175:117-123, 2004 Hajnóczky, G., Buzas, C.J., Pacher, P., Hoek, J.B. and Rubin, E. (2005) Alcohol and mitochondria in cardiac apoptosis: Mechanisms and visualization. Alcohol. Clin. Exp. Res. 29, 693-701, 2005

176.

16

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 18 of 26

PUBLICATIONS BOOK CHAPTERS, EDITORIALS, REVIEWS AND PUBLISHED LECTURES 1. Popper, H., Barka, T., Cohen, S., Goldfarb, S., Hutterer, F., Paronetto, F., Rubin, E., Schaffner, F., Singer, E.J. and Zak, P.G.: Factors related to the chronicity of liver disease. A progress report. J. Mt. Sinai Hosp. 28: 351-360, 1961. Popper, H., Barka, T., Goldfarb, S., Hutterer, F., Paronetto, F., Rubin, E., Schaffner, F., Singer, E.J. and Zak, F.G.: Studies on the progression from acute hepatic injury to fibrosis of the liver. J. Mt. Sinai Hosp. 29: 152-164, 1962. Popper, H., Schaffner, F., Rubin, E., Barka, T. and Paronetto, F.: Mechanism of intrahepatic cholestasis in drug-induced hepatic injury. Ann. New York Acad. Sci. 104: 998-1013, 1963. Popper, H., Hutterer, F., Rubin, E. and Oudea, P.: Biochemie de la fibrogenese hepatique. Exp. Ann. de Biochem. Med. 24: 227-238, 1963. Rubin, E.: Interpretation of the liver biopsy. Diagnostic criteria. Gastroenterology 45: 400-412, 1963. Popper, H., Barka, T., Goldfarb, S., Hutterer, F., Paronetto, F., Rubin, E. and Schaffner, F.: Factors determining chronicity of liver disease. A progress report. J. Mt. Sinai Hosp. 30: 336, 1963. Rubin, E. and Popper, H.: Pathologic alterations in irreversible shock. In: Shock and Hypotension, Mills, L.C. and Moyer, H.H., Ed. New York, Grune & Stratton, 1965, pp. 629-636. Rubin, E. and Hutterer, F.: Hepatic fibrosis. Studies in formation and resorption of hepatic collagen. In :The Connective Tissue, Wagner, F.M. and Smith, D.E., Ed. Baltimire, Williams & Wilkins, 1967, pp. 142-160. Rubin, E. and Hutterer, F.: Methods in the study of structural changes induced by experimental chronic hepatic injury. In: Methods and Achievements in Experimental Pathology, Bajusz, E. and Jasmin, G.,Ed., Basel and New York, S. Karger, Vol. 2, 1967, pp. 224-242. Rubin, E. and Hutterer, F.: Studies of hepatic collagen and ground substance during recovery from chronic liver injury. In: Liver Research, Vandenbroucke, J., DeGrotte, J. and Standaert, L.O., Ed., Antwerp, St. Catherine Press, Ltd., 1967, pp. 372-375. Rubin, E.: Studies in hepatic injury induced by experimental portacaval shunts. Israel J. Med. Sci. 4: 155-158, 1968. Lieber, C.S. and Rubin, E.: Ethanol: A hepatotoxic drug. Gastroenterology 54: 642646, 1968. Rubin, E. and Lieber, C.S.: Malnutrition and liver disease. relationship. Am. J. Med. 45: 1-6, 1968. An overemphasized

2.

3.

4. 5. 6.

7.

8.

9.

10.

11. 12. 13. 14.

Rubin, E. and Lieber, C.S.: Alcohol, other drugs and the liver. Ann. Int. Med. 69: 1063-1067, 1968.
17

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 19 of 26

15.

Rubin, E. and Popper, H.: Laboratory examination in the diagnosis of chronic hepatitis. In: Laboratory Diagnosis in Liver Disease, Sunderman, F.W. and Sunderman, F.W., Jr., Ed., St. Louis, Mo., Green, Inc., 1968, pp. 316-320. Rubin, E. and Lieber, C.S.: Alcohol-induced hepatic injury in man. In: Biochemical and Clinical Aspects of Alcohol Metabolism, Sardesai, V.M., Ed., Springfield, Illinois, Charles C. Thomas & Co., 1969, pp. 212-232. Lieber, C.S., Rubin, E. and DeCarli, L.M.: Respective roles of dietary and metabolic factors in pathogenesis of alcoholic fatty liver. The biochemical basis for the ethanolinduced liver injury. In: Biochemical and Clinical Aspects of Alcohol Metabolism, Sardesai, V. M., Ed., Springfield, Illinois, Charles C. Thomas & Co. 1969, pp. 176-188. Rubin, E.: Correlation of biochemical and functional hepatic changes with ethanolinduced ultrastructural alterations. In: Metabolic Changes Induced by Alcohol. Martini, G. A. and Bode, C., Ed., Heidelberg-New York, Springer-Verlag, 1971, pp. 70-75. Rubin, E. and Lieber, C.S.: Alcoholism, alcohol and drugs. Science 172: 1097-1102, 1971. Rubin, E. and Lieber, C. S.: Ethanol and the liver: An example of injury and adaptation. Human Pathol. 2: 343-348, 1971. Lieber, C.S., Rubin, E. and DeCarli, L.M.: Effects of ethanol on lipid, uric acid, intermediary and drug metabolism, including the pathogenesis of the alcoholic fatty liver. In: The Biology of Alcoholism. Kissen, B. and Begleiter, H., Ed., New York, Plenum Press. 1: 1971, pp. 263-305. Lieber, C.S., Rubin, E. and DeCarli, L.M.: Chronic and acute effects of ethanol on hepatic metabolism of ethanol, lipids and drugs: Correlation with ultrastructural changes. In: Recent Advances in Studies of Alcoholism. Mello, N. K. and Mendelson, J. H., Ed., U.S. Government Printing Office, Washington, D. C., 1971. Rubin, E.: Functional significance of ethanol-induced ultra-structural alterations of the liver. In: Alcohol and the Liver. Gerok, W., Sickinger, K. and Hennekeuser, H. H., Ed., F. K. Schattauer Verlag, Stuttgart-New York, 1971, pp. 147-154. Lieber, C.S., Rubin, E., DeCarli, L. M. and Joly, J. G.: Etude des effets morphologiques et metaboliques de l'alcohol sur le foie. Rev. Medicochir Mal Foie 46: 233-240, 1971. Rubin, E.: The spectrum of alcoholic liver injury. In: The Liver. Gall, E. A., Ed., Baltimore, Williams & Wilkins Co., 1972, pp. 199-217. Rubin, E., Beattie, D.S., Toth, A. and Lieber, C.S.: Structural and functional effects of ethanol on hepatic mitochondria. Symposium: Mechanisms of Chemically-induced Disease. Fed. Proc. 31: 131-140, 1972. Feinman, L., Rubin, E. and Lieber, C.S.: Adaptation of the liver to drugs. In: Liver and Drugs. Jezequel, A. M. and Orlandi, F., Eds., New York, Academic Press, 1972, pp. 4183. Rubin, E. and Lieber, C.S.: The effects of ethanol on the liver. In: International Rev. Exper. Pathol., Vol. 11, Richter, G. W. and Epstein, M. A., Eds., New York and London, Academic Press. 1972, pp. 177-232.
18

16.

17.

18.

19. 20. 21.

22.

23.

24. 25. 26.

27.

28.

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 20 of 26

29.

Rubin, E. and Lieber, C.S.: Ethanol metabolism in the liver. In: Progress in Liver Disease. Vol. IV, Chapter 32., Popper, H. and Schaffner, F., Eds., New York, Grune & Stratten,1972, pp. 549-566. Lieber, C.S., DeCarli, L.M., Gang, H., Walker, G. and Rubin, E.: Hepatic effects of long-term ethanol consumption in primates. In: Medical Primatology, Proc. 3rd Conference Exp. Med. Surg. Primates. Vol. III, Goldsmith, E. I. and Moor-Janowski, J., Eds., Basel, S. Karger, 1972, pp. 270-278. Rubin, E.: Metabolic changes in mitochondria induced by ethanol. First International Gstaad Symposium. The Liver. Quantitative Aspects of Structure and Function. Paumgartner, G. and Preisig, R., Eds., 1973, pp. 259-268. Rubin, E. and Cederbaum, A.I.: Effect of chronic ethanol consumption and acetaldehyde on mitochondrial functions and the transfer of reducing equivalents. In: Alcohol and Aldehyde Metabolizing Systems, Thurman, R. G., Yonetani, T., Williamson, J. R. and Chance, B. Eds., New York, Academic Press, 1974. pp. 435-455. Rubin, E. and Lieber, C.S.: The effects of alcohol on the human liver. In: The Liver and its Diseases. Schaffner, F., Sherlock, S. and Leevy, C., Eds., New York, International Medical Book Corp., 1974. pp. 236-244. Rubin, E.: Morphologic studies of alcoholic liver injury. In: Alcohol and Abnormal Protein Biosynthesis. Rothschild, M. A., Oratz, M. and Schreiber, S. S., Eds., Pergamon Press, 1974. pp. 295-319. Rubin, E.: Alcohol and the liver. IV. Congreso de la Sociedad Latinoamericana de Hepatologia. In: Hepatologia. Beker, S. G. and Grases, P. J., Eds., 1974. pp. 134-136. Rubin, E. and Cederbaum, A.I.: Effects of ethanol and acetaldehyde on hepatic mitochondria. In: Alcoholic Liver Pathology. Khanna, J. M., Israel, Y. and Kalant, H., Eds., Addiction Research Foundation, Toronto, Canada, 1975. pp. 305-329. Rubin, E., Editor: Symposium on pathology of the gastrointestinal tract. Part I. Human Path. 6: 5-75, 1975. Rubin, E., Editor: Symposium on pathology of the gastrointestinal tract. Part II. Human Path. 6: 157-250, 1975. Rubin, E.: Pathologist vs. clinician (Editorial). Human Path. 6: 127-128, 1975. Rubin, E. and Lieber, C.S.: Relation of alcoholic liver injury to cirrhosis. In: Clinics in Gastroenterology, Vol. 4, Schmitt, W. R., Ed., London, W. B. Saunders Co., 1975. pp. 247-272. Rubin, E. and Cederbaum, A.I.: Molecular localization of mitochondrial injury produced by chronic ethanol consumption and acetaldehyde. 2nd International Gstaad Symposium. The Liver. Quantitative Aspects of Structure and Function. Preisig, R., Bircher, J. and Paumgartner, G., Eds., 1976. pp. 192-204. Cederbaum, A.I. and Rubin, E.: Molecular mitochondrial liver injury produced by chronic alcohol and acetaldehyde. In: Symposium on Biological Aspects of Alcoholism. Fed. Proc. 34: 2045-2051, 1975.

30.

31.

32.

33.

34.

35. 36.

37. 38. 39. 40.

41.

42.

19

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 21 of 26

43.

Cederbaum, A.I., Lieber, C.S. and Rubin, E.: The effects of chronic ethanol consumption and acetaldehyde on hepatic mitochondria. In: Diseases of the Liver and Biliary Tract, 5th Quadr. Meeting International Association of the Study of the Liver, Acapulco, Leevy, C. M., Ed., Basel, S. Karger, 1976. pp. 85-91. Lieber, C.S., Rubin, E., DeCarli, L.M. and Feinman, L.: Respective roles of ethanol and protein deficiency in the pathogenesis of alcoholic hepatitis and cirrhosis. In: Diseases of the Liver and Biliary Tract. 5th Quadr. Meeting International Association of the Study of the Liver, Acapulco, Leevy, C. M., Ed., Basel, S. Karger, 1976. pp. 92-98. Geller, S.A. and Rubin, E.: The effects of alcohol on striated and smooth muscle. In: Metabolic Aspects of Alcoholism, Lieber, C. S., Ed., Baltimore, University Park Press, 1977. pp. 187-213. Rubin, E.: Primary hepatocellular carcinoma - a resume. In: Liver Cell Cancer. Cameron, H. M., Linsell, D. A. and Warwick, G. P., Eds., Elsevier Scientific Publ. Co., 1976. pp. 279-286. Rubin, E. and Cederbaum, A.I.: Organelle pathology of alcoholic liver disease. In: Alcohol and the Liver. Israel, Y. and Khanna, J. M., Eds., New York City, Plenum Press, 1976. pp. 167-193. Lieber, C.S., Feinman, L. and Rubin, E.: Alcohol and the liver. In: Gastroenterology, Vol. III, Bockus, H. L., Ed., Philadelphia, W. B. Saunders Co., 1976: pp. 342-365. Gang, H., Rubin, E. and Kamath, S.A.: Hepatic plasma membrane enzymes in acute alcoholism. Proc. IVth Internat.Congress on Liver Diseases. Basel, Switzerland, 1976. Cederbaum, A.I., Dicker, E., Lieber, C.S. and Rubin, E.: Factors contributing to the adaptive increase in ethanol metabolism due to chronic consumption of ethanol. In: Alcoholism: Clinical and Experimental Research. Grune & Stratton, Inc., 1977. pp. 2731. Rubin, E. and Cederbaum, A.I.: Organelle pathology of alcohol-induced hepatic injury. In: Alcohol and the Liver. Fischer, M. M. and Rankin, J. G., Eds., New York, Plenum Press, 1977. pp. 167-196. Rubin, E.: Metabolic and pathologic changes in muscle during acute and chronic administration of ethanol. In: Biochemistry and Pharmacology of Ethanol, Vol. I, Majchrowicz, E. and Noble, E. P., Eds., New York, Plenum Press, 1979. pp. 623-639. Rubin, E.: Alcoholic myopathy in heart and skeletal muscle. New England J. Med. 301: 28-33, 1979. Rubin, E.: Effects of alcohol and acetaldehyde in vitro and in vivo, on subcellular constituents of the heart. Workshop on Cardiomyopathies, Jennings, R. B. and Morgan, H. E., Chairman, NIH Publication #79-1608, 1979, p. 6. Rubin, E.: Acute and chronic viral hepatitis. Fed. Proc. 38: 2665-2673, 1979. Rottenberg, H., Robertson, D.E. and Rubin, E.: The temperature dependence of respiration and ATPase in rat liver mitochondria is altered by ethanol. Adv. Exp. Med. Biol. 132: 345-353, 1980.

44.

45.

46.

47.

48. 49. 50.

51.

52.

53. 54.

55. 56.

20

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 22 of 26

57. 58. 59. 60. 61. 62. 63.

Thayer, W.S. and Rubin, E.: Effects of chronic ethanol consumption on the respiratory chain of rat liver submitochondrial particles. Adv. Exp. Med. Biol. 132: 385-392, 1980. Rubin, E.: Iatrogenic hepatic injury. Human Pathol. 2: 312-331, 1980. Rubin, E.: Alcohol: Tonic or toxic? Cardiovascular Rev. and Rep. 2: 23-29, 1981. Rubin, E.: (Book Review). Liver biopsy interpretation, P. J. Scheuer, 3rd Ed., Bailliere Tindall, London, 1980, Human Pathol. 12: 296, 1981. Rubin, E.: Cardiovascular effects of alcohol. Proceedings of Fifth Biennial Symposium on Alcoholism, Cardiff, Wales. Pharmacol. Biochem. Behavior. 13: 37-41, 1980. Rubin, E.: Viral hepatitis: A symposium. Human Pathol. 12: 1060-1122, 1981. Rubin, J.I. and Rubin, E.: Myocardial toxicity of alcohols, aldehydes and glycols, including alcoholic cardiomyopathy. In: Cardiovascular Toxicology, Van Stee, E. W., Ed., Raven Press, 1982. pp. 353-363. Rubin, E.: Alcohol and the heart: Theoretical considerations. Fed. Proc. 41: 24602464, 1982. Rubin, E. and Rottenberg, H.: Ethanol-induced injury and adaptation in biological membranes. Fed. Proc. 41: 2465-2471, 1982. Skarinsky, E. and Rubin, E.: The biology of viral hepatitis. In: Current Topics in Inflammation and Infection. Internat. Academy of Pathology Monograph #23. Baltimore, Waverly Press, 1982. pp. 156-187. Rubin, E.: Command performance. JAMA 13: 1689, 1984. Taraschi, T.F. and Rubin, E.: The effects of ethanol on the chemical and structural properties of biological membranes. Lab. Invest. 52: 120-130, 1985. Taraschi, T.F. and Rubin, E.: Ethanol and biological membranes: Experimental studies and theoretical considerations. In: Alcohol Related Diseases in Gastroenterology. Seitz, H. K. and Kommerell, B., Eds., Berlin, Heidelberg, Springer-Verlag, 1985. pp. 213-231. Taraschi, T.F., Thayer, W.S., Ellingson, J.S. and Rubin, E.: Effects of ethanol on the structure and function of rat liver mitochondrial and microsomal membranes. In: Membrane Pathology. Bianchi, G., Carafoli, E. and Scarpa, A., Eds., Ann. NY Acad Sci. 488: 127-139, 1986. Rubin, E. Editorial: A new format for manuscripts. Lab. Invest. 55: 599, 1986. Taraschi, T.F. and Rubin, E.: The interaction of ethanol with biological membranes: An overview: In: Pathogenesis of Liver Diseases. Farber, E., Phillips, M. J. and Kaufman, N., Eds., Internat. Acad. Path. Monograph., Baltimore, Williams & Wilkins, 1987. pp. 113-135. Taraschi, T.F., Ellingson, J.S. and Rubin, E.: Membrane structural alterations caused by chronic ethanol consumption: The molecular basis of membrane tolerance. In: Alcohol and the Cell. Rubin, E., Ed., Ann. NY Acad. Sci. 492: 171-179, 1987.

64. 65. 66.

67. 68. 69.

70.

71. 72.

73.

21

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 23 of 26

74.

Pryor, C.L., Stubbs, C.D. and Rubin, E.: Phospholipase activity is enhanced in liver microsomes from chronic alcoholic rats. In: Alcohol and the Cell. Rubin, E., Ed., Ann. NY Acad. Sci. 492:207-209, 1987. Nie, Y., Stubbs, C.D. and Rubin, E.: Chronic ethanol ingestion decreases the partitioning of hydrophobic molecules into cell membranes due to an alteration in the phospholipids. In: Alcohol and the Cell. Rubin, E., Ed., Ann. NY Acad. Sci. 492: 210-211, 1987. Thomas, A.P., Hoek, J.B. and Rubin, E.: Elevation of inositol 1,4,5-trisphosphate levels after acute ethanol treatment of rat hepatocytes. In: Alcohol and the Cell, Rubin, E., Ed., Ann. NY Acad. Sci. 492: 250-252, 1987. Dorio, R.J., Hoek, J.B., Forman, H.J. and Rubin, E.: The effect of ethanol on superoxide production in alveolar macrophages. In Alcohol and the Cell, Rubin, E., Ed., Ann. NY Acad. Sci. 492: 324-326, 1987. Hoek, J.B., Taraschi, T.F. and Rubin, E.: Functional implications of the interaction of ethanol with biologic membranes. Actions of ethanol on hormonal signal transduction systems. Seminars in Liver Dis. 8: 36-46, 1988. Taraschi, T.F., Ellingson, J. S. and Rubin, E.: Mechanism of Ethanol Action on Biological Membranes. In Alcoholism: Origins and Outcome, Rose, R. M. and Barrett, J., Raven Press, New York, 221-228, 1988. Thomas, A.P., Hoek, J.B., Rubin, R. and Rubin, E.: Activation of the inositol-1,4,5trisphosphate signaling system by acute ethanol treatment of rat hepatocytes. In Cell Calcium Metabolism, Gary Fiskum (Ed.), Plenum Publishing Corp., 1989. Rubin, E.: How alcohol damages the body. Alcohol Health and Research World. 13: 322-327, 1989. Rubin, E. and Farber, J.L.: Environmental diseases of the digestive system. In: Environmental Medicine, Upton, A.C., ed. Med. Clin. N. America 74: 413-424, 1990. Hoek, J.B. and Rubin, E.: Alcohol and membrane-associated signal transduction. Alcohol & Alcoholism, 25: 143-156, 1990. Rubin, E. and Doria, J.: Alcoholic cardiomyopathy. Alcohol Health & Research World. 14: 277-284, No. 4, 1990. Frank, E. D., Honet, J., Torjman, M., Janes, N., Rubin, E., Barber, M. and Taraschi, T.: Effects of chronic exposure to nitrous oxide on membrane fluidity in rats. In: Molecular and Cellular Mechanisms of Alcohol and Anesthetics. Ann. NY Acad. Sci. 625: 545547, 1991. Taraschi, T. F., Lee, Y. C., Janes, N. and Rubin, E.: Anesthetic potency and conformational stability in membranes. In: Molecular and Cellular Mechanisms of Alcohol and Anesthetics. Ann. NY Acad. Sci. 625: 698-706, 1991. Rubin, E. and Thomas, A. P.: Alcohol Effects on the Heart and Cardiovascular System. In: Medical Diagnosis and Treatment of Alcoholism, Third Edition, J. Mendelson, Ed., McGraw Hill, New York, 263-287, 1992. Hoek, J.B., Thomas, A.P., Rooney, T.A., Higashi, K. and Rubin, E.: Ethanol and signal transduction in the liver. FASEB J. 6: 2386-2396, 1992.
22

75.

76.

77.

78.

79.

80.

81. 82. 83. 84. 85.

86.

87.

88.

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 24 of 26

89.

Stubbs, C.D. and Rubin, E.: Molecular Mechanisms of Ethanol and Anesthetic Actions: Lipid- and Protein-Based Theories. In: Alcohol, Cell Membranes, and Signal Transduction in Brain. C. Alling, et al., Eds., Plenum Press, New York, 1-11, 1993. Rubin, E. The chemical pathogenesis of alcohol-induced tissue injury. Alcohol Health & Research World 17, No. 4: 272-278, 1993. Thomas, A.P., Rozanski, D.J., Renard, D.C. and Rubin, E.: Effects of ethanol on the contractile function of the heart: A review. Alcoholism: Clin. Exp. Res. 18: 121-131, 1994. Rubin, E. and Urbano-Marquez, A: Alcoholic cardiomyopathy. Alcoholism, Clinical Experimental Research 18: 111-114, 1994. Rubin, E.: Alcohol Abuse. In: Pathology of Environmental and Occupational Disease. J.E. Craighead, Ed., Mosby Year Book, 1995. Rubin, E.: Drug tolerance in biomembranes: Commentary for 25th anniversary of NIAAA. Alcohol Health and Research World 19: 46-47, 1995. Nalpas, B., Feitelson, M., Brechot, C. and Rubin, E.: Alcohol, hepatotropic viruses and hepatocellular carcinoma. Alcoholism: Clin. Exp. Res. 19:1089-1095, 1995. Israel, Y and Rubin, E.: Alcohol-Induced Liver Injury. In: Drug-Induced Hepatotoxicity. Cameron, R.G., Feuer G., de la Iglesia F., eds., Handbook of Experimental Pharmacology 21:611-628, Springer Berlin, 1996. Rubin, E. The questionable link between alcohol intake and cancer. Clin. Chim. Acta 246:143-148, 1996. Rubin, E. and Urbano-Marquez, A. Clinical Effects of Alcohol on the Cardiovascular System, In: NIAAA Research Monograph, Zakhari, S. and Wassef M., eds., NIH, Bethesda, MD 31:127-136, 1996 Rubin, E. Alcoholic Liver Disease: New Perspectives. Adv. In Path. Lab. Med., 9:393413, 1996 Mosby Yearbook, St. Louis, MO. Hoek, J.B. and Rubin, E. Intracellular signal transduction in liver regeneration. In: Liver Growth and Repair. (Strain, A. and Diehl, A.M. eds) Chapter 14, Thompson Science Publishers, London, UK, 366-401, 1999. McPherson, K., Cavallo, F., Rubin, E. Alcohol and Breast Cancer. In: Health Issues related to Alcohol Consumption. (MacDonald, I. ed.) Blackwell Science, Ltd, 2nd ed. pp216-242,1999. Mutti, L., Giuseppe, C., Giordano, A., Rubin, E. Carcinogenic Effect of Simian Virus 40 and Asbestos Fibers on Rb Family Proteins and Cell Cycle Machinery of malignant Mesothelioma Cells. In: Sourcebook on Asbestos Disease, Peters, G.A. and Peters, B.J., Eds., California, LEXIS Law Publishing, 1999, Vol 19, pp361394. Ponnappa, B.C., Rubin, E.: Modeling Alcohol's Effects on Organs in Animal Models. Alcohol Research & Health 24(2)93-104, 2000.
23

90. 91.

92. 93. 94. 95. 96.

97. 98.

99. 100.

101.

102.

103.

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 25 of 26

104.

Spies, C.D., Sander, M., Stangl, K., Fernandez-Sola, J., Preedy, V.R., Rubin, E., Andreasson, S., Hanna, E.Z., Kox, W.J.: Effects of alcohol on the heart. Current Opinion in Critical Care 7:337-343, 2001.

24

Case 1:03-cv-02608-WDM-MJW
Emanuel Rubin, M.D.

Document 71-3

Filed 11/30/2006

Page 26 of 26

BOOKS: ADVANCES IN THE BIOLOGY OF DISEASE. Rubin, E. and Damjanov. I., Eds., Williams & Wilkins, Baltimore, Md., 1984. ALCOHOL AND THE CELL, Rubin, E., Ed., Ann. NY Acad. Sci., New York, Vol. 492, 1987. PATHOLOGY, Rubin, E. and Farber, J.L., Eds., J.B. Lippincott Co., Philadelphia, Pa., 1988. PATHOLOGY REVIEWS 1989, Rubin, E. and Damjanov, I., Eds., Humana Press, Clifton, N.J., 1989. PATHOLOGY A Study Guide, Damjanov, I. and Rubin, E.: J.B. Lippincott Co., Philadelphia, Pa., 1990. ESSENTIAL PATHOLOGY, Rubin, E. and Farber, J.L., Eds., J.B. Lippincott Co., Philadelphia, Pa., 1990. MOLECULAR AND CELLULAR MECHANISMS OF ALCOHOL AND ANESTHETICS. Rubin, E., Miller, K.W. and Roth, S.H., Eds., Ann. NY Acad. Sci., New York, Vol. 625, 1991. PATHOLOGY, Second Edition, Rubin, E. and Farber, J.L., Eds., J.B. Lippincott Co., Philadelphia, Pa., 1994. REVIEW OF PATHOLOGY, Damjanov, I. and Rubin, E.: J.B. Lippincott Co., Philadelphia, Pa., 1994. ESSENTIAL PATHOLOGY, Second Edition, Rubin, E. and Farber, J.L., Eds., J.B. Lippincott Co., Philadelphia, Pa., 1995. PATHOLOGY STUDY GUIDE: Learning Objectives with Short Answers. Damjanov, I., Fendersaon B.A., Rubin, E. Eds., Thomas Jefferson University, Philadelphia, PA, 1997. PATHOLOGY Q&A, Fenderson, B.A., Damjanov, I., Rubin, E., Eds., Thomas Jefferson University, Philadelphia, PA, 1998. PATHOLOGY, Third Edition, Rubin, E. and Farber, J.L., Eds., Lippincott-Raven Co., Philadelphia, Pa., 1998. Rubin's PATHOLOGY, Fourth Edition, Rubin, E., Ed., Lippincott, Williams & Wilkins, Philadelphia and Baltimore, 2005.

CD ROMS: PATHOLOGY Q&A, Fenderson, B.A., Damjanov, I., Rubin, E., Thomas Jefferson University, Philadelphia, Pa., 2000.

25